DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Dscam2

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	1200	Identity:	243/1200 - (20%)
Similarity:	403/1200 - (33%)	Gaps:	313/1200 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 MERIPRGPYFVKQPNDTTFDVNKNRLI-----------------NDVTLSCLANGYPTPSYTWYR 402
            |.|:.| ...|..|  |...:|.:|.|                 ....|.|:|.|.|:|.|:|:
  Fly   212 MHRLTR-QVVVSSP--TRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWF- 272

  Fly   403 EVYVDDRLEYQKIDPLAQDRYTISG------GNLIIYEPKQALDQGAYHCVAENKFGRIRSE--- 458
                    .:....||.    .:||      |.::..|.....|.|.|.|.|.|..|...:|
  Fly   273 --------THNGAGPLP----VLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRL 325

  Fly   459 ---------------SAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHYPDVRYYWARDYFP 508
                           |.|:  |...||   |...||.         ..|....::.:|......|
  Fly   326 TVATPIQVEISPNVLSVHM--GGTAEF---RCLVTSN---------GSPVGMQNILWYKDGRQLP 376

  Fly   509 NFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFAN 573
            :....:..:.|.|        :...:|..|.|.|:....||.:......|...|    ..|:::.
  Fly   377 SSGRVEDTLVVPR--------VSRENRGMYQCVVRRPEGDTFQATAELQLGDAP----PVLLYSF 429

  Fly   574 TFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNA------YTINYGRVLI---IQN 629
            ....:.|     |..:.|:|.|.|.|.|..:||..|.||..|.      |...:|.|:.   |.:
  Fly   430 IEQTLQP-----GPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISH 489

  Fly   630 ATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQF-TIPLKDMIKDYNSDVTFICEAFAIPDANYT 693
            ....|.|||:|...|....:..:..:||...|.. .||....:.  ...:...|.....|.....
  Fly   490 VMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVS--GETLNLKCPVAGYPIEEIH 552

  Fly   694 WYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQN-------------------- 738
            |.:....| |.:| |.| :..|..|||..::|:.|..:|.|.|:|
  Fly   553 WERGGREL-PDDI-RQR-VQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKL 614

  Fly   739 --------QLK------------------------------------------------------ 741
                    ||.
  Fly   615 SPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGS 679

  Fly   742 --------------TSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWK 792
                          ....::|..::::.|.:...|:::.|..  |.:..:.|..:..|.|...||
  Fly   680 DHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVER--NRHIMLHCQAQGVPTPSIVWK 742

  Fly   793 K-------DGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRF 850
            |       :.:.:......::|.:|:|.:.....|.||.|.|.|:|..||.......:.:....:
  Fly   743 KATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPY 807

  Fly   851 IETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKN---NH----------DGTGRII 902
            ..:..:.::.|:.|...|.|..:.|:.::|  ||..:|:...|   |:          ||...
  Fly   808 FSSTSRSVMVKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATPDGVSA-- 868

  Fly   903 VDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISK---------- 957
                .|.:......|:|.|.|...:..........:.::..|..|..::...||.
  Fly   869 ----ELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPK 929

  Fly   958 -------TKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNL 1015
                   ||.|:|:.:..|:.....:.:     .|.:..|....|..|.            :.||
  Fly   930 TLGTGDVTKYIVEFREADHSLPPALFVD-----QWQQIEVKDPPHFNAM------------IENL 977

  Fly  1016 TPWSAYEFSVTAVNDLGIGTPSAPSP--IYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQE 1078
            .|.:.|.|.|.|....|   .||||.  |..|...:|...|.::........:|.|:|...||:.
  Fly   978 KPATRYAFRVIAEGSAG---RSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPEL 1039

  Fly  1079 QH----SHGIHYKV---------FWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQ 1130
            :|    .:.:.||:         |..:.|..:..:.|:...   |:|        .:..|.|.||
  Fly  1040 RHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLS---GLA--------KFARYTVVVQ 1093

  Fly  1131 AINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKY 1195
            |.|.||.||.||.....:.||:|...|:.....|.:|....|:|||..:...|  |.|.|::|.:
  Fly  1094 AFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTN--GLLQGYKLIF 1156

  Fly  1196 ------WKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRK 1254
                  .:.:..|.:|    .:||....::.||:..|.|.::|:|:...|:|..|:.....:...
  Fly  1157 EPIIDDIQPSKDEVES----RKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEED 1217

  Fly  1255 APQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKV--RIWESDQNMITANNTIVPIGQKL 1317
            .|: .|:.:.|...:..::.:.|  :.|::....:..|.:  |:....:.:   ||....:..:.
  Fly  1218 VPE-APADIKVVSSSSQSLYISW--LPPNEPNGVITKYSLYTRVVNGREEL---NNEKRSLPSQQ 1276

  Fly  1318 ESY-INNLTPGKSYNMRVLAYSNGGDGRMS 1346
            ..| ...|.|...|...|.|.:..|:|:.|
  Fly  1277 AYYEAKGLHPHMEYQFWVTASTRVGEGKSS 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/139 (20%)
		I-set	362..462	CDD:254352	29/140 (21%)
		Ig	466..559	CDD:299845	16/92 (17%)
		IG_like	584..657	CDD:214653	23/81 (28%)
		IGc2	586..645	CDD:197706	22/67 (33%)
		Ig	667..751	CDD:299845	21/179 (12%)
		IG_like	676..751	CDD:214653	21/170 (12%)
		IG_like	765..844	CDD:214653	20/85 (24%)
		Ig	773..844	CDD:299845	18/77 (23%)
		I-set	851..940	CDD:254352	18/101 (18%)
		Ig	866..944	CDD:299845	16/90 (18%)
		FN3	944..1043	CDD:238020	25/117 (21%)
		FN3	1053..1146	CDD:238020	26/105 (25%)
		fn3	1156..1244	CDD:278470	24/93 (26%)
		fn3	1259..1346	CDD:278470	16/89 (18%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	22/101 (22%)
		Ig	247..327	CDD:299845	22/92 (24%)
		I-set	332..418	CDD:254352	19/107 (18%)
		IGc2	344..407	CDD:197706	15/84 (18%)
		IG_like	432..517	CDD:214653	24/89 (27%)
		IGc2	436..507	CDD:197706	24/75 (32%)
		I-set	521..610	CDD:254352	21/93 (23%)
		IGc2	533..597	CDD:197706	18/68 (26%)
		Ig	630..699	CDD:143165	0/68 (0%)
		IG_like	714..802	CDD:214653	21/89 (24%)
		Ig	725..802	CDD:299845	18/76 (24%)
		Ig	823..894	CDD:143165	16/78 (21%)
		FN3	906..1006	CDD:238020	26/119 (22%)
		FN3	1013..1111	CDD:238020	26/108 (24%)
		FN3	1119..1209	CDD:238020	25/95 (26%)
		FN3	1219..1313	CDD:238020	17/93 (18%)
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010