DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn1a

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_851300.2	Gene:	cntn1a / 353150	ZFINID:	ZDB-GENE-030427-1	Length:	1032	Species:	Danio rerio

Alignment Length:	1046	Identity:	297/1046 - (28%)
Similarity:	466/1046 - (44%)	Gaps:	146/1046 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKI------DPLA 419
            ||.|.:||.||.:......  ..:||:|.....|..||.|        ||...::      ||
Zfish    45 GPVFEEQPLDTIYPEESPE--EKITLTCRTRANPPASYRW--------RLNNAELVLAEGGDP-- 97

  Fly   420 QDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNL-KRSAETSEMNW 483
              .|::|.|||:|..|.::...|.|.|||.|::|.:.|..|.:.||::..|:. :|.|...:...
Zfish    98 --HYSVSEGNLLISSPDKSKHAGNYTCVASNQYGSVTSRRARVQFGYLDMFSTDEREAVYVKEGQ 160

  Fly   484 GKSIFCDPPQHYP-DVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLV 546
            |..:.|.||.|:| |:.:.|..:.||.|:..|||.|||:. |.||.|.:.:.|..||||.|.:
Zfish   161 GAVLLCAPPPHFPEDLSFRWMLNEFPEFIPLDQRRFVSQSTGNLYISTVRSTDSGNYSCFVSS-- 223

  Fly   547 SDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVA----------------------GDEI 589
                                 ..|..:.|.|..|..|:|                      |..|
Zfish   224 ---------------------PAIAKSVFSKFIPLVPIAERSLRKYPADIKVKSPDSWALLGQNI 267

  Fly   590 RLECMAFGYPIPSYNWTRQG--LPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKS 652
            .|||.|.|.|||...|.:..  ||..|:..::: |.:|.:.:....|.|.|.|...|.:......
Zfish   268 TLECFALGNPIPQIRWRKLDGVLPPLRHDVSMS-GALLHLYSLQYEDEGLYECEADNSKGKDWHK 331

  Fly   653 IYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNV 717
            .::.::..|.:...:.....|...|....|:|...|..:..:.||.......:
Zfish   332 THLYVEGAPDWLEQISSSEVDIGGDYIMSCQASGKPKPHVHFLKNGHMYMKGH------------ 384

  Fly   718 LTIKFLEKD-KDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDP 781
             .::|.... :|..||||.|:|:.....::|:|||.:..|||:.:|::.::....||.....|.|
Zfish   385 -EVRFSRLGFEDSGMYQCVAENRHGVIHANAELRVFASAPSFQYNPVKPKLLGARNGRVVFECRP 448

  Fly   782 EAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQ 846
            .|||||...|.|..:::.:.....|...|:|.:...|:.|||.|||.|.|..|...|...:.:..
Zfish   449 RAAPRPNITWSKGTELLHNSSRISIWLDGSLELLNISKSDEGKYTCFAENDRGRANSTGSLSITD 513

  Fly   847 EIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHD------------GTG 899
            ..:....|....||...| ..:.|.|:.|..||:.::|..:|..:....|            ||.
Zfish   514 ATKITLAPSNADVSVGED-ARMECVASHDPGLDLTFIWSLDGHTIDLQRDAQHYQRKMDSASGTS 577

  Fly   900 RIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEW 964
            .     :.|.:.:|.:|.||.|.|..::.|:..::...:.:.|.||.||||:|.:::.....:.|
Zfish   578 S-----SELLITHTQLRHAGRYSCTAQTPVDNTTASAELVVRGPPGPPGGVRVDEVTSDSVRVLW 637

  Fly   965 VDGSHNGRAIRYYNI-LGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAV 1028
            ..|:.|...|..|.: |..:...:.|.:.:|    ..|:...:.:.|.||||.||:.|||.|.|.
Zfish   638 SHGTDNLSPISRYTVQLRESAAQQDWRDAAT----SPVNVEGNAEMATVVNLLPWTEYEFRVIAT 698

  Fly  1029 NDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLK 1093
            |.||.|.||.|||..:|.|.:|.:||.::|||||...:|||||.|:..|..:.....|.:.:|..
Zfish   699 NTLGTGPPSEPSPKTTTREARPIVAPSDIGGGGGTSRELTITWTPVQSQYYYGSNFGYIIAFKPH 763

  Fly  1094 GAIEW-----ASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMP 1153
            ...||     ...|::|..|..   ..||.:   |.:|||::|.||.|:||.|..|.|:||:|:|
Zfish   764 NDPEWLRVTVTDPEVQKYVHKD---PKIPPS---TRFEVKMKAFNSQGEGPFSNSAFIYSAQDVP 822

  Fly  1154 QVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTR-NWA 1217
            ..||....|.|.::|...|.|.|:.:.      .:..::::||:.:.:.|.|...:..::| |..
Zfish   823 AEAPIITEARALSATEAIVIWVPVQLP------TVERYQVRYWRESVENEASAQRVLVSSRENHT 881

  Fly  1218 LIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPP----SSVHVYGINPSTVRVVWR 1278
            .:..::||::|.|:|.|.|.||.||.|:|....|.:..|.:||    :.:|..|   |::.:.|.
Zfish   882 RLDNMKPDSHYLVEVRACNGAGYGPASQRNRIYTKKSPPSRPPKIISTKMHYSG---SSINIAWE 943

  Fly  1279 YVSPSQDEEPVEGYKVRIWESDQ---NMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNG 1340
            .|....:|..|.||||...:..|   .:.|.....:.:..:...|:          :.|.|:|.|
Zfish   944 KVESLNNESTVAGYKVLYRQHGQPSGTLYTTEKQSIDLPMRRGEYL----------VEVRAHSEG 998

  Fly  1341 GDGRMS 1346
            |||.::
Zfish   999 GDGAVA 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	33/104 (32%)
		I-set	362..462	CDD:254352	33/105 (31%)
		Ig	466..559	CDD:299845	30/95 (32%)
		IG_like	584..657	CDD:214653	22/96 (23%)
		IGc2	586..645	CDD:197706	20/60 (33%)
		Ig	667..751	CDD:299845	17/84 (20%)
		IG_like	676..751	CDD:214653	16/75 (21%)
		IG_like	765..844	CDD:214653	25/78 (32%)
		Ig	773..844	CDD:299845	24/70 (34%)
		I-set	851..940	CDD:254352	22/100 (22%)
		Ig	866..944	CDD:299845	19/89 (21%)
		FN3	944..1043	CDD:238020	37/99 (37%)
		FN3	1053..1146	CDD:238020	35/97 (36%)
		fn3	1156..1244	CDD:278470	25/88 (28%)
		fn3	1259..1346	CDD:278470	23/93 (25%)
cntn1a	NP_851300.2	Ig	45..136	CDD:299845	33/104 (32%)
		I-set	46..134	CDD:254352	31/101 (31%)
		Ig	142..237	CDD:299845	33/117 (28%)
		IG_like	154..229	CDD:214653	28/97 (29%)
		Ig	249..337	CDD:299845	21/88 (24%)
		IG_like	256..336	CDD:214653	21/80 (26%)
		Ig	341..418	CDD:299845	17/89 (19%)
		IG_like	347..418	CDD:214653	17/83 (20%)
		I-set	423..511	CDD:254352	29/87 (33%)
		Ig5_Contactin_like	440..511	CDD:143170	24/70 (34%)
		I-set	516..611	CDD:254352	22/100 (22%)
		Ig	530..611	CDD:299845	19/86 (22%)
		FN3	627..714	CDD:238020	30/90 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..729		14/29 (48%)
		FN3	723..816	CDD:238020	35/98 (36%)
		FN3	825..905	CDD:214495	23/85 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	907..926		6/18 (33%)
		FN3	920..1001	CDD:214495	22/93 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1476
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm24534
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3370
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910