DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and robo3

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster

Alignment Length:	1085	Identity:	232/1085 - (21%)
Similarity:	372/1085 - (34%)	Gaps:	284/1085 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 PYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTIS 426
            |..|:.|.|||...::     ..||:|.|.|.|||:..||::...      .||.| ...|.|:.
  Fly    23 PRIVEHPIDTTVPRHE-----PATLNCKAEGSPTPTIQWYKDGVP------LKILP-GSHRITLP 75

  Fly   427 GGNLI---IYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIM-EFNLKRSAETSEMNWGKS- 486
            .|.|.   :...::..|.|.|.|.|:|:.|..||.:|.|....:. ||.|:  .:.:.:..|.:
  Fly    76 AGGLFFLKVVNSRRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLE--PQNTRIAQGDTA 138

  Fly   487 -IFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTG 550
             :.|..|:..|:....|.:......:|..:||.:...|.|........|...|.|..:.
  Fly   139 LLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKN------ 197

  Fly   551 RNGPFFPLRVTPNSNYQALIFANTFPKVF----PEAPVAGDEIRLECMAFGYPIPSYNWTRQ--- 608
                  |:.|..:|  .|.:..:..|.:.    .:..:.|..:...|...|.|:|...|.|.
  Fly   198 ------PVGVRESS--LATLKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASG 254

  Fly   609 -GLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIK 672
             .:||.|  .::...|.|.::..|..|.|||||...|....:.....:.:...|:|.........
  Fly   255 GNMPLDR--VSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSV 317

  Fly   673 DYNSDVTFICEAFAIPDANYTW--YKNAERLDPANINRDRYIIQD-----NVLTIKFLEKDKDDA 730
            :..:|.:|.|.|...|.....|  ..|:..:.|.....||:...:     ::||:...::...|.
  Fly   318 ELGADTSFECRAIGNPKPTIFWTIKNNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDL 382

  Fly   731 MYQCGAQNQLKTSFSSAQLRVLSMK----------PSFKKHPLESEVYAVYNGNTTIVCDPEAAP 785
            :..|.|.|::.:..|..||.:.|.:          |..:..|::|        ..|:.|.....|
  Fly   383 VILCNAMNEVASITSRVQLSLDSQEDRPPPIIISGPVNQTLPIKS--------LATLQCKAIGLP 439

  Fly   786 RPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSR-DDEGIYTCIASNQAG--TDESHARVIV--L 845
            .|...|.:||..:.......|..||.|.||...| .|:|:|||:||::||  |.....|:.:  .
  Fly   440 SPTISWYRDGIPVQPSSKLNITTSGDLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTN 504

  Fly   846 QEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTV 910
            ..|:|...|.|.
  Fly   505 PNIKFYRAPEQT----------------------------------------------------- 516

  Fly   911 HNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIR 975
                       :|                    |.|||..:::..:.:...|.|......|.:
  Fly   517 -----------KC--------------------PSAPGQPKILNATASALTIVWPTSDKAGAS-- 548

  Fly   976 YYNILGR------TNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIG 1034
              :.||.      ||.:|||:.:::.:         |.....|.:||..:||.|.|.|.|.||.
  Fly   549 --SFLGYSVEMYCTNQSRTWIPIASRL---------SEPIFTVESLTQGAAYMFIVRAENSLGF- 601

  Fly  1035 TPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWA 1099
              |.||||     .:|..|.:.||...|  .:.|.|...||
  Fly   602 --SPPSPI-----SEPITAGKLVGVRDG--SESTGTSQLLL------------------------ 633

  Fly  1100 SDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALA 1164
                                                     |::..:..|.|:.::..    |.|
  Fly   634 -----------------------------------------SDVETLLQANDVVELLE----ANA 653

  Fly  1165 YNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWA--LIVGL-QPDT 1226
            .:||...::|. || |.:.|.|..:     |.:..|..|..:..|....:..:  .:.|| :..|
  Fly   654 SDSTTARLSWD-ID-SGQYIEGFYL-----YARELHSSEYKMVTLLNKGQGLSSCTVPGLAKAST 711

  Fly  1227 YYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPV-E 1290
            |.|..|..|.:....|.:.| ..||....|:.||..:.....|.::|.:.|....|::....: .
  Fly   712 YEFFLVPFYKSIVGKPSNSR-RMRTLEDVPEAPPYGMEAIQFNRTSVFLKWLPPQPNRTRNGILT 775

  Fly  1291 GYKVRIWESDQNMIT---ANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSP-TLH 1351
            .|.|.:...|.:..|   .|.||......|  .:.|||.|.:|.:.|.|.:..|.|..|.| .|.
  Fly   776 SYNVVVKGLDVHNTTRIFKNMTIDAAAPTL--LLANLTTGVTYYIAVAAATRVGVGPFSKPAVLR 838

  Fly  1352 FQMGKTTRNGANTRHGHNINTA----------LILSTLLLISTFL 1386
            ......:.:...||:..:.:.|          ::|.:::.|..||
  Fly   839 IDARTQSLDTGYTRYPISRDIADDFLTQTWFIVLLGSIIAIIVFL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	32/100 (32%)
		I-set	362..462	CDD:254352	33/102 (32%)
		Ig	466..559	CDD:299845	17/95 (18%)
		IG_like	584..657	CDD:214653	20/76 (26%)
		IGc2	586..645	CDD:197706	19/62 (31%)
		Ig	667..751	CDD:299845	19/90 (21%)
		IG_like	676..751	CDD:214653	19/81 (23%)
		IG_like	765..844	CDD:214653	26/81 (32%)
		Ig	773..844	CDD:299845	25/73 (34%)
		I-set	851..940	CDD:254352	3/88 (3%)
		Ig	866..944	CDD:299845	1/77 (1%)
		FN3	944..1043	CDD:238020	30/104 (29%)
		FN3	1053..1146	CDD:238020	9/92 (10%)
		fn3	1156..1244	CDD:278470	22/90 (24%)
		fn3	1259..1346	CDD:278470	23/90 (26%)
robo3	NP_608592.2	Ig	22..117	CDD:299845	34/105 (32%)
		I-set	23..116	CDD:254352	34/104 (33%)
		I-set	122..211	CDD:254352	20/104 (19%)
		Ig	125..211	CDD:299845	18/101 (18%)
		I-set	215..302	CDD:254352	21/88 (24%)
		Ig	232..302	CDD:299845	19/71 (27%)
		I-set	306..401	CDD:254352	19/94 (20%)
		Ig	320..411	CDD:299845	20/90 (22%)
		I-set	412..492	CDD:254352	26/87 (30%)
		IGc2	429..489	CDD:197706	21/59 (36%)
		FN3	519..612	CDD:238020	32/113 (28%)
		FN3	644..735	CDD:238020	24/102 (24%)
		fn3	743..832	CDD:278470	23/90 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840