DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Nrcam

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006516011.1	Gene:	Nrcam / 319504	MGIID:	104750	Length:	1308	Species:	Mus musculus

Alignment Length:	1149	Identity:	284/1149 - (24%)
Similarity:	449/1149 - (39%)	Gaps:	251/1149 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 IELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLIN 382
            :.|.||:|:   :.|:  :::.||.|.       ::|:.:.|  ....:.|.|...|..:|
Mouse    17 VPLILFLCQ---MISA--LDVPLDPKL-------LHDLVQPP--TITQQSPKDYIIDPREN---- 63

  Fly   383 DVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLII---YEPKQALDQGAY 444
             :.:.|.|.|.|.||::|.|.   ....:..| |||...:  ...|.|:|   .|.|....:|.|
Mouse    64 -IVIQCEAKGKPPPSFSWTRN---GTHFDIDK-DPLVTMK--PGSGTLVINIMSEGKAETYEGVY 121

  Fly   445 HCVAENKFGR-------IRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIF--CDPPQHYPDVRY 500
            .|.|.|:.|.       :|...:.|        ..|...|...:..|:|:.  |.||...|....
Mouse   122 QCTARNERGAAVSNNIVVRPSRSPL--------WTKERLEPIVLQNGQSLVLPCRPPIGLPPAII 178

  Fly   501 YWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC------------------------ 540
            :|..:.|.. :.:.:||....:|.||||.:...| |.:|.|
Mouse   179 FWMDNSFQR-LPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISLKVISVD 242

  Fly   541 ----TVQTLVSDT-------GRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECM 594
                |:...:|||       .:..|  |..:||..|..            .:..:.|:.:.|||:
Mouse   243 ELNDTIAANLSDTEFYGAKSSKERP--PTFLTPEGNES------------HKEELRGNVLSLECI 293

  Fly   595 AFGYPIPSYNWTRQG--LPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINI 657
            |.|.|.|...|.::.  ||..|..|. |:.:.|.|.:.:..|:|.|.|...|....:..:|.:.:
Mouse   294 AEGLPTPIIYWIKEDGMLPANRTFYR-NFKKTLQITHVSEADSGNYQCIAKNALGAVHHTISVTV 357

  Fly   658 QMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKF 722
            :..|.:.:..::::.....:.|.||.|...|....:|..|...::.|..:..|.|..|.::....
Mouse   358 KAAPYWIVAPQNLVLSPGENGTLICRANGNPKPRISWLTNGVPIEIALDDPSRKIDGDTIIFSNV 422

  Fly   723 LEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVY-NGNTTIVCDPEAAPR 786
              ::...|:|||.|.|:.....::|.:.||:..|.....  .:.:|.|. |....:.|....:|.
Mouse   423 --QESSSAVYQCNASNKYGYLLANAFVNVLAEPPRILTS--ANTLYQVIANRPALLDCAFFGSPM 483

  Fly   787 PKFQWKKDGQVIGSGGHRRIL---PSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEI 848
            |..:|.|..:  ||..|..|.   .:|||.|....:|..|.|||:|.|:.|..::...:.:....
Mouse   484 PTIEWFKGTK--GSALHEDIYVLHDNGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT 546

  Fly   849 RFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVW-KHNGEVLKNNHDGTGRIIVDWNRLTVHN 912
            |.|:.|...:|.:...:.| .|....|..|....:| |.||| |.|:.    |...|.:.|.|.:
Mouse   547 RIIKQPEYAVVQRGSKVSF-ECRVKHDHTLIPTIMWLKDNGE-LPNDE----RFSTDKDHLVVSD 605

  Fly   913 TSMRDAGDYECVVKSAVNEISSK----------TSVSIEGAPGAPGGVQVI-QISK--------- 957
            ....|.|.|.|...:.::..|:.          |...|...|..|..:::. |:.|
Mouse   606 VKDDDGGTYTCTANTTLDSASASAVLRVVAPTPTPAPIYDVPNPPFDLELTNQLDKSVQLTWTPG 670

  Fly   958 -------TKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEV--- 1012
                   ||.|||:.|..|:.               ..|                 |.||||
Mouse   671 DDNNSPITKFIIEYEDAMHDA---------------GLW-----------------RHQAEVSGT 703

  Fly  1013 -----VNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWD 1072
                 :.|:|:..|.|.|.|.|.:|...||..|..|.|...:|...|..|.|.|.:..:|.|||.
Mouse   704 QTTAQLKLSPYVNYSFRVMAENSIGRSMPSEASEQYLTKAAEPDQNPMAVEGLGTEPDNLVITWK 768

  Fly  1073 PLLPQEQHSHGIHYKVFWKLK-GAIEWASDEIKKQDHMGVAVVNIPLNNY-------YTEYEVKV 1129
            ||...:.:..|:.|||.|:.| |..||.|          |.|.|:  :.|       :..|.:||
Mouse   769 PLNGFQSNGPGLQYKVSWRQKDGDDEWTS----------VVVANV--SKYIVSGTPTFVPYLIKV 821

  Fly  1130 QAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLK 1194
            ||:|.||..||....:.||.||:|.|||........|||...|.|.|:  ..:::||.|.|:|:.
Mouse   822 QALNDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSVVNSTLAEVHWDPV--PPKSVRGHLQGYRIY 884

  Fly  1195 YWKTTHQEEDSVYYLSRT------TRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYR 1253
            ||||....:.:..::.:.      |:...::.||||.::|.:.|...|..||||.|   .:|.:.
Mouse   885 YWKTQSSSKRNRRHIEKKILTFQGTKTHGMLPGLQPYSHYALNVRVVNGKGEGPAS---TDRGFH 946

  Fly  1254 KAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQN-------------MIT 1305
             .|:..||:       ||::::    |:|:.|...:|      |:...:             .|.
Mouse   947 -TPEGVPSA-------PSSLKI----VNPTLDSLTLE------WDPPSHPNGILTEYILQYQPIN 993

  Fly  1306 ANNTIVPI------GQKLESYINNLTPGKSYNMRVLAYSNGGDG 1343
            :.:.:.|:      ..|....:.||.....|.....|.::.|.|
Mouse   994 STHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSVGPG 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/108 (26%)
		I-set	362..462	CDD:254352	28/109 (26%)
		Ig	466..559	CDD:299845	27/130 (21%)
		IG_like	584..657	CDD:214653	22/74 (30%)
		IGc2	586..645	CDD:197706	20/60 (33%)
		Ig	667..751	CDD:299845	18/83 (22%)
		IG_like	676..751	CDD:214653	18/74 (24%)
		IG_like	765..844	CDD:214653	24/82 (29%)
		Ig	773..844	CDD:299845	21/73 (29%)
		I-set	851..940	CDD:254352	24/99 (24%)
		Ig	866..944	CDD:299845	22/88 (25%)
		FN3	944..1043	CDD:238020	28/123 (23%)
		FN3	1053..1146	CDD:238020	34/100 (34%)
		fn3	1156..1244	CDD:278470	29/93 (31%)
		fn3	1259..1346	CDD:278470	18/104 (17%)
Nrcam	XP_006516011.1	Ig_NrCAM	64..140	CDD:143282	23/81 (28%)
		Ig	145..237	CDD:386229	22/100 (22%)
		Ig	288..358	CDD:386229	21/70 (30%)
		Ig4_NrCAM	375..450	CDD:143276	18/76 (24%)
		IGc2	469..532	CDD:197706	21/64 (33%)
		Ig	547..633	CDD:386229	24/91 (26%)
		FN3	647..737	CDD:238020	27/121 (22%)
		fn3	750..832	CDD:365830	32/93 (34%)
		fn3	848..938	CDD:365830	27/91 (30%)
		fn3	953..1037	CDD:365830	16/100 (16%)
		fn3	1068..1136	CDD:365830
		Bravo_FIGEY	1191..1280	CDD:372781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810