DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Nrg

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	1063	Identity:	271/1063 - (25%)
Similarity:	454/1063 - (42%)	Gaps:	132/1063 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 RGPYFVKQ--PNDTTFDV---NKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLA 419
            |.|...||  |.:..|.|   ||.. .|...:.|.|:|.|.|.|:|.:        ..:|.|..|
  Fly    27 RPPRITKQPAPGELLFKVAQQNKES-DNPFIIECEADGQPEPEYSWIK--------NGKKFDWQA 82

  Fly   420 QDRYTI---SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEM 481
            .|...:   ..|.|:|..||.. |:|.|.|.|.|:||...|.|.::....:..|. ..:|:|.|.
  Fly    83 YDNRMLRQPGRGTLVITIPKDE-DRGHYQCFASNEFGTATSNSVYVRKAELNAFK-DEAAKTLEA 145

  Fly   482 NWGKSIF--CDPPQHYPDVRYYWARDYFPNFVEE----------DQRVFVSRDGALYFSFIETVD 534
            ..|:...  |..|..:|.....|       .::|          :.|:.:..:|.|:||.:...|
  Fly   146 VEGEPFMLKCAAPDGFPSPTVNW-------MIQESIDGSIKSINNSRMTLDPEGNLWFSNVTRED 203

  Fly   535 RAN---YSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFA--NTFPKV------FPEAPVAGDE 588
            .::   |:|:..::.....:.|....|.|.     |..:.|  |..|.|      .....:.|..
  Fly   204 ASSDFYYACSATSVFRSEYKIGNKVLLDVK-----QMGVSASQNKHPPVRQYVSRRQSLALRGKR 263

  Fly   589 IRLECMAFGYPIPSYNWTRQGLPLQRNAYTI--NYGRVLIIQNATTNDNGEYSCTITNPRKTLMK 651
            :.|.|:..|.|:|...|::.|..:|.:....  :||:.|:|:....:|.|.|:|.::|.......
  Fly   264 MELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQS 328

  Fly   652 -SIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQD 715
             ||.:|:...|.||...:......:.:|.|.|.|..:|:...:|..|.:.::.:..| .|..:.|
  Fly   329 FSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPN-PRRTVTD 392

  Fly   716 NVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCD 780
            |.:.|..|.|. |...|.|.|.|.|...:....|.|.:..|:..:.|  :.|..|...|.||.|.
  Fly   393 NTIRIINLVKG-DTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAP--AAVSTVDGRNVTIKCR 454

  Fly   781 PEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVL 845
            ...:|:|..:|.:....: :||...:..:|.|.|...:..|.|.|||.|.|:.|..::...::|.
  Fly   455 VNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVK 518

  Fly   846 QEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRII-VDWNRLT 909
            :..|..:.|....|:......| .|..|.|:.|:|...|..:|:.:  :.:...|.: .:.|.||
  Fly   519 EHTRITQEPQNYEVAAGQSATF-RCNEAHDDTLEIEIDWWKDGQSI--DFEAQPRFVKTNDNSLT 580

  Fly   910 VHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAI 974
            :..|...|:|:|.||.::.::|.:::.::.::..|.|| .:..|.....||.|.|.....|...|
  Fly   581 IAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAP-KLTGITCQADKAEIHWEQQGDNRSPI 644

  Fly   975 RYYNILGRT-----NWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIG 1034
            .:|.|...|     :|:..:            ::..:...:.||.::||:.|.|.|.|.|.:|..
  Fly   645 LHYTIQFNTSFTPASWDAAY------------EKVPNTDSSFVVQMSPWANYTFRVIAFNKIGAS 697

  Fly  1035 TPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLK-GAIEW 1098
            .|||.|...:|..|.|:..|.||.|.|.:..:|.|:|.|:...|.::...||.|.||.. .|..|
  Fly   698 PPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAW 762

  Fly  1099 ASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIA----VIHSAEDMPQVAPQK 1159
            .::.|.......:.:.:.|.   :.:|.:||.|||..|   ||.:|    |.:|.||.|..||..
  Fly   763 ENNNIFDWRQNNIVIADQPT---FVKYLIKVVAINDRG---ESNVAAEEVVGYSGEDRPLDAPTN 821

  Fly  1160 -PIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSV--YYLSRTTRNWALIVG 1221
             .:....:||...:.|.|:  |.|::||...|::::.| |.::.|:.:  .::...|.| ||:..
  Fly   822 FTMRQITSSTSGYMAWTPV--SEESVRGHFKGYKIQTW-TENEGEEGLREIHVKGDTHN-ALVTQ 882

  Fly  1222 LQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDE 1286
            .:||:..:.:::|||....||.|...:..|....| .|...:..|.:..|...:.|:  .|....
  Fly   883 FKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVP-SPVQGLDAYPLGSSAFMLHWK--KPLYPN 944

  Fly  1287 EPVEGYKVRIWESDQNMITANNTIVPIGQKLE--SYINN----------LTPGKSYNMRVLAYSN 1339
            ..:.|||:...|..::.         :|::.|  .:|.:          |.|...|.:.:.|.:.
  Fly   945 GKLTGYKIYYEEVKESY---------VGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTK 1000

  Fly  1340 GGDGRMSSPTLHFQMGKTTRNGA 1362
            .|:|     :.|: :.|||...|
  Fly  1001 MGEG-----SEHY-IEKTTLKDA 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	34/106 (32%)
		I-set	362..462	CDD:254352	35/107 (33%)
		Ig	466..559	CDD:299845	19/107 (18%)
		IG_like	584..657	CDD:214653	20/75 (27%)
		IGc2	586..645	CDD:197706	17/60 (28%)
		Ig	667..751	CDD:299845	21/83 (25%)
		IG_like	676..751	CDD:214653	21/74 (28%)
		IG_like	765..844	CDD:214653	22/78 (28%)
		Ig	773..844	CDD:299845	20/70 (29%)
		I-set	851..940	CDD:254352	21/89 (24%)
		Ig	866..944	CDD:299845	19/78 (24%)
		FN3	944..1043	CDD:238020	28/103 (27%)
		FN3	1053..1146	CDD:238020	29/97 (30%)
		fn3	1156..1244	CDD:278470	25/90 (28%)
		fn3	1259..1346	CDD:278470	18/98 (18%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	26/81 (32%)
		IG_like	57..127	CDD:214653	26/78 (33%)
		Ig	135..214	CDD:299845	18/86 (21%)
		IG_like	141..216	CDD:214653	16/81 (20%)
		ig	251..332	CDD:278476	19/80 (24%)
		I-set	339..427	CDD:254352	24/89 (27%)
		Ig	354..427	CDD:299845	21/74 (28%)
		I-set	432..517	CDD:254352	24/87 (28%)
		Ig	446..517	CDD:299845	20/71 (28%)
		I-set	522..611	CDD:254352	22/91 (24%)
		ig	525..609	CDD:278476	21/86 (24%)
		FN3	613..707	CDD:238020	28/106 (26%)
		FN3	716..807	CDD:238020	29/96 (30%)
		fn3	817..905	CDD:278470	25/91 (27%)
		FN3	917..1004	CDD:238020	18/98 (18%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10657
eggNOG	1	0.900	-	-		E1_KOG3513
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20648at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820