DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cont and l1camb

DIOPT Version :10

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_571458.1 Gene:l1camb / 30656 ZFINID:ZDB-GENE-980526-512 Length:1269 Species:Danio rerio


Alignment Length:1096 Identity:274/1096 - (25%)
Similarity:443/1096 - (40%) Gaps:188/1096 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 PYHYGLDINDMERIPRGPYFVKQP-NDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDD 408
            |:.|     ...::.:.|.|..|| ..|.|.      ::||.|:|.|:|.|:||:.|     |.|
Zfish    38 PHDY-----TYNKLKQAPEFTTQPVPHTAFS------LDDVNLACEASGDPSPSFRW-----VKD 86

  Fly   409 RLEYQKIDPLAQDRYTISGGNLIIYEPKQALD--QGAYHCVAENKFGRIRSESAHLNFGFIMEFN 471
            ..::.::         :|....:...|...|.  ||.|.|.|.|:.|...|...||....:....
Zfish    87 GKQFGEV---------LSESGTLTPHPTMDLHFYQGTYRCYAANELGTAVSNLVHLTTEPVPSLA 142

  Fly   472 LKRSAETSEMNWGKS--IFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYF-SFIETV 533
            ..:..:......|:|  :.|:||:.....:.:|....| :.:..::||.:||||.||| :.|...
Zfish   143 KVKKQKRRAYEVGESAVLRCNPPKSSVTPKIHWMDMQF-HHIPLNERVTISRDGNLYFANLIAND 206

  Fly   534 DRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEA-------PVAGDEIRL 591
            .|.:|:|....:.:..........:.|||:::    :..|...|:...|       .:.|..:.|
Zfish   207 SRDDYTCNAHYINASIILPKEPMSIYVTPSNS----VVKNRRAKLHHPAGARSSYLVLRGQTLTL 267

  Fly   592 ECMAFGYPIPSYNWTRQGLPLQRNAYTINY-GRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYI 655
            ||:..|.|.|..:|.|....|..|.....| .|.|.|.|...:|:|||.||..|...::.....:
Zfish   268 ECIPEGLPTPEVHWDRIDSALSPNRTKKLYNNRWLQIDNVLESDDGEYVCTARNSENSVKHHYTV 332

  Fly   656 NIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVL-- 718
            .::..|.:|...::.:......|...|:|..||..|.||..|...:...:::..|.:....::  
Zfish   333 TVEAAPYWTRRPEEHLYAPGETVRLDCQADGIPAPNITWSINGVPVSGTDVDPRRRVSSGKLILS 397

  Fly   719 TIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIV-CDPE 782
            .::|    .|.|:|||.|.|:..:...:..:.|:.: |:....| :..:|....|.|.:: |...
Zfish   398 NVEF----SDTAVYQCEAVNKHGSILINTHVHVVEL-PAQILTP-DERLYQATAGQTVMLDCRTF 456

  Fly   783 AAPRPKFQWK-KDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDES-HARVIVL 845
            .:|.||..|: .|.....|......:.:|:|.||..|.:|...|||..|.   |::| .|.:.||
Zfish   457 GSPLPKIHWEILDSIPALSNAKISQMTNGSLKISNVSEEDSNRYTCSVSE---TNKSISAELEVL 518

  Fly   846 QEIRFIETPPQRI-VSKEHDLIFLHCEAAFDELLDIAYV-WKHNGEVLKNN------HDGTGRII 902
            ...:.: .|||.: |.:..|.| |||:...|..|....| ||.:|..:..:      |:..|   
Zfish   519 NRTKIV-GPPQNLHVIRGSDAI-LHCKYTVDHNLKSPTVQWKKDGHKITASTSNDKYHEIEG--- 578

  Fly   903 VDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDG 967
                .|.|.:..|.|.|.|.|.|.:.::..::...::::..|..|..:::.:..:....|.|:..
Zfish   579 ----SLKVLDVQMEDMGIYSCGVSTTLDSDTASGYITVQDKPDPPQSLKLSEKMERSVTISWMPS 639

  Fly   968 SHNGRAIRYYNI---LGRT----NWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSV 1025
            ..|...:..|.|   .|.|    .|.: :.:||..::..|            ::|.|:|.|.|.:
Zfish   640 VENNSPVTEYVIEMNEGETPDEGQWQK-YRSVSQDIRQLE------------IHLQPYSKYHFQI 691

  Fly  1026 TAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFW 1090
            .|||.:|...||..|..|||...||...|.||.........:.|:|..:..::.:..|..|||||
Zfish   692 RAVNSIGTSAPSESSLSYSTPAAKPDRNPENVMTLSTDPKSMIISWQEMDRRQFNGPGFQYKVFW 756

  Fly  1091 KL---KGAIEWASDEIKKQDHMGVAVVNIPL--NN--YYTEYEVKVQAINSVGKGPESEIAVIHS 1148
            :.   .|| .|...          :|.|.||  ||  .:..:|:||||:|.:|..||....:.:|
Zfish   757 RRAADSGA-HWTES----------SVSNPPLLVNNTGTFVSFEIKVQAVNDLGAAPEPLTVIGYS 810

  Fly  1149 AEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTT 1213
            .||.|..||..........|...|.|.|:  ..|::||.|:|:::              ||....
Zfish   811 GEDFPLEAPSALSVTELQKTSVMVRWSPV--RPESVRGHLLGYKI--------------YLRMKG 859

  Fly  1214 RNWALIVGLQP--------------------DTYYF----VKVMAYNAAGEGPESERFEERTYRK 1254
            .:..|..|..|                    |..|:    :.:.|:|:.||||.||.....|   
Zfish   860 PSGRLRAGRSPAVGNPTVIEVPADAAEKIVSDLQYYSDYTLTITAFNSKGEGPHSEESSFST--- 921

  Fly  1255 APQKPPSSVHVYGI-NPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIG---- 1314
             |:..|..|..... :||...:..|:.:|.:....:.||.::..|            |.||    
Zfish   922 -PEGAPGPVLFLPFDSPSESEITLRWEAPHKPNGEIRGYLLQYQE------------VVIGSESP 973

  Fly  1315 QKLESY---------INNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNG 1361
            |.:||.         :.||.|...|...:.|.::.|||   :|.:  |.|.|..:|
Zfish   974 QHVESIDLPAVTEFTLKNLNPESRYTFHLSARNSAGDG---APAI--QSGATLLDG 1024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..466 CDD:472250 31/107 (29%)
Ig strand B 384..388 CDD:409356 2/3 (67%)
Ig strand C 397..409 CDD:409356 3/11 (27%)
Ig strand E 428..432 CDD:409356 0/3 (0%)
Ig strand F 443..448 CDD:409356 2/4 (50%)
Ig strand G 457..460 CDD:409356 1/2 (50%)
Ig 474..559 CDD:472250 20/87 (23%)
Ig strand B 485..489 CDD:409392 1/5 (20%)
Ig strand C 499..503 CDD:409392 0/3 (0%)
Ig strand E 523..527 CDD:409392 2/3 (67%)
Ig strand F 537..542 CDD:409392 2/4 (50%)
Ig strand G 553..556 CDD:409392 0/2 (0%)
Ig_3 584..644 CDD:464046 22/60 (37%)
Ig_3 660..738 CDD:464046 19/79 (24%)
Ig 756..844 CDD:472250 25/90 (28%)
Ig strand B 775..779 CDD:409358 1/4 (25%)
Ig strand C 788..792 CDD:409358 1/3 (33%)
Ig strand E 810..814 CDD:409358 2/3 (67%)
Ig strand F 824..829 CDD:409358 3/4 (75%)
Ig strand G 837..840 CDD:409358 1/3 (33%)
Ig <868..944 CDD:472250 19/82 (23%)
Ig strand C 881..885 CDD:409359 1/4 (25%)
Ig strand E 906..910 CDD:409359 1/3 (33%)
Ig strand F 920..925 CDD:409359 2/4 (50%)
Ig strand G 933..936 CDD:409359 0/2 (0%)
FN3 944..1043 CDD:238020 25/105 (24%)
FN3 1053..1146 CDD:238020 29/99 (29%)
fn3 1156..1244 CDD:394996 24/111 (22%)
fn3 1259..1346 CDD:394996 23/100 (23%)
l1cambNP_571458.1 Ig 50..133 CDD:472250 29/102 (28%)
Ig strand B 67..71 CDD:409353 2/3 (67%)
Ig strand C 80..84 CDD:409353 2/8 (25%)
Ig strand E 98..101 CDD:409353 0/2 (0%)
Ig strand F 114..119 CDD:409353 2/4 (50%)
Ig strand G 128..131 CDD:409353 1/2 (50%)
Ig 146..233 CDD:472250 20/87 (23%)
Ig strand B 158..162 CDD:409353 0/3 (0%)
Ig strand C 172..176 CDD:409353 0/3 (0%)
Ig strand E 195..199 CDD:409353 2/3 (67%)
Ig strand F 210..215 CDD:409353 2/4 (50%)
Ig strand G 226..229 CDD:409353 0/2 (0%)
Ig3_L1-CAM 253..335 CDD:409460 23/81 (28%)
Ig strand B 265..269 CDD:409460 1/3 (33%)
Ig strand C 278..282 CDD:409460 0/3 (0%)
Ig strand E 300..304 CDD:409460 2/3 (67%)
Ig strand F 314..319 CDD:409460 3/4 (75%)
Ig strand G 327..330 CDD:409460 0/2 (0%)
Ig 339..427 CDD:472250 19/91 (21%)
Ig strand B 355..359 CDD:409353 1/3 (33%)
Ig strand C 368..372 CDD:409353 2/3 (67%)
Ig strand E 392..396 CDD:409353 0/3 (0%)
Ig strand F 406..411 CDD:409353 3/4 (75%)
Ig strand G 419..422 CDD:409353 0/2 (0%)
IG_like 441..517 CDD:214653 23/78 (29%)
Ig strand B 449..453 CDD:409353 0/3 (0%)
Ig strand C 462..467 CDD:409353 2/4 (50%)
Ig strand E 485..489 CDD:409353 2/3 (67%)
Ig strand G 510..513 CDD:409353 1/2 (50%)
Ig 523..612 CDD:472250 25/97 (26%)
Ig strand B 538..542 CDD:409353 2/4 (50%)
Ig strand C 554..558 CDD:409353 1/3 (33%)
Ig strand E 578..582 CDD:409353 2/10 (20%)
Ig strand F 592..597 CDD:409353 2/4 (50%)
Ig strand G 605..608 CDD:409353 0/2 (0%)
FN3 616..706 CDD:238020 24/102 (24%)
FN3 719..798 CDD:214495 26/89 (29%)
FN3 817..921 CDD:238020 26/119 (22%)
FN3 926..1014 CDD:238020 23/102 (23%)
FN3 1025..>1095 CDD:238020 274/1096 (25%)
Bravo_FIGEY 1148..1233 CDD:464016
Blue background indicates that the domain is not in the aligned region.

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