DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and CNTN6

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001276009.1	Gene:	CNTN6 / 27255	HGNCID:	2176	Length:	1028	Species:	Homo sapiens

Alignment Length:	1045	Identity:	319/1045 - (30%)
Similarity:	507/1045 - (48%)	Gaps:	113/1045 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 PYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYRE-VYVDDRLEYQKIDPLAQDRYTI 425
            |.|.::|:|..|.::.::  ::|.|:|.|||||:|.|.|.:. ..:|..:.|         .|.:
Human    26 PIFTQEPHDVIFPLDLSK--SEVILNCAANGYPSPHYRWKQNGTDIDFTMSY---------HYRL 79

  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWGKSIFC 489
            .||:|.|..|....|.|.|.|:|.|..|.|.|..|.|.|.:|.:|..| ||..:.....|..:.|
Human    80 DGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLC 144

  Fly   490 DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSDTGRNG 553
            .||.|:.|:.|.|..:..|.:|:||.|.|||:: |.||.:.:|..|..||:|.:....:.....|
Human   145 GPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQG 209

  Fly   554 PFFPLRVTPNSNYQALIFANTFPKV---FPEAPVAGDE--IRLECMAFGYPIPSYNWTR-QGLPL 612
            |..||....:.     :.....||:   |||...|..:  ::|||.|.|.|:|..:|.| .|.||
Human   210 PPTPLVQRTDG-----VMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPL 269

  Fly   613 QRNAYTINYGR---VLIIQNATTNDNGEYSCTITNPR-KTLMKSIYINIQMRPQFTIPLKDMIKD 673
            ...   :.|.:   :|.|.|....|.|.|.|..:|.| :.|.|...| ....|::...:::....
Human   270 PGK---VKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLI-FYAPPEWEQKIQNTHLS 330

  Fly   674 YNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQN 738
            ...::.:.|:|...|:..|||.||.|||:|    .:|..|::..|.|..|.. .|..:|||.|:|
Human   331 IYDNLLWECKASGKPNPWYTWLKNGERLNP----EERIQIENGTLIITMLNV-SDSGVYQCAAEN 390

  Fly   739 QLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGH 803
            :.:..:::|:||||:..|.|.|.|::.:.:....|:..|.|.|.|.||....||:..:.:.....
Human   391 KYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKR 455

  Fly   804 RRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFL 868
            ..:|..|:|.|...:|.|.|.|||||:||.||.::...:|| :|...|..||.::.....:.|.|
Human   456 IFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIV-KERTVITVPPSKMDVTVGESIVL 519

  Fly   869 HCEAAFDELLDIAYVWKHNGEVLKNNHDGT-------GRIIVDWNRLTVHNTSMRDAGDYECVVK 926
            .|:.:.|..:::.:||..||:|: :...|.       |..:.|   |.:.|..:..:|.|.|.|:
Human   520 PCQVSHDPSIEVVFVWFFNGDVI-DLKKGVAHFERIGGESVGD---LMIRNIQLHHSGKYLCTVQ 580

  Fly   927 SAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVN 991
            :.:..:|:...:.:.|.||.|..|||..||.|.:.:.|..|..|...|:.:.|..||.::..|..
Human   581 TTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQA 645

  Fly   992 VSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRN 1056
            |:|..:......|    .|.||.|:||..|||.|.|.|.:|||.||.||.:..|....|.:||.|
Human   646 VATVPEILNGKTY----NATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVN 706

  Fly  1057 VGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVN---IPL 1118
            :.||||...:|.|||:.:..:.|:..|..|.:.::..|:..|:.:::...:.......|   |||
Human   707 IHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPL 771

  Fly  1119 NNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSREN 1183
                :.:||||...|:.|:|..|.:.:::|.||.||:||:.....:::::...|:|..|..:|..
Human   772 ----SPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNT 832

  Fly  1184 IRGKLIGHRLKYWKTTHQEEDSVYYLSR-----TTRNWALIVGLQPDTYYFVKVMAYNAAGEGPE 1243
              |:::|:.:.||  |...::|:....|     ||:|   |.||:.:|.||..|.|||.||.||.
Human   833 --GRVLGYEVLYW--TDDSKESMIGKIRVSGNVTTKN---ITGLKANTIYFASVRAYNTAGTGPS 890

  Fly  1244 SERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQ---NMIT 1305
            |......|.:..|.:||::: .:.:..|.:.:.|.:|...::|..|.|||:...::.|   :::.
Human   891 SPPVNVTTKKSPPSQPPANI-AWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILE 954

  Fly  1306 ANNT----IVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDG---------RMSS---------- 1347
            .|||    :||..:             .|.:.:...|:||||         :|||
Human   955 TNNTSAELLVPFEE-------------DYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRGIQFLE 1006

  Fly  1348 PTLHF 1352
            |:.||
Human  1007 PSTHF 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	33/98 (34%)
		I-set	362..462	CDD:254352	34/100 (34%)
		Ig	466..559	CDD:299845	32/94 (34%)
		IG_like	584..657	CDD:214653	26/79 (33%)
		IGc2	586..645	CDD:197706	20/64 (31%)
		Ig	667..751	CDD:299845	25/83 (30%)
		IG_like	676..751	CDD:214653	25/74 (34%)
		IG_like	765..844	CDD:214653	25/78 (32%)
		Ig	773..844	CDD:299845	25/70 (36%)
		I-set	851..940	CDD:254352	22/95 (23%)
		Ig	866..944	CDD:299845	20/84 (24%)
		FN3	944..1043	CDD:238020	39/98 (40%)
		FN3	1053..1146	CDD:238020	28/95 (29%)
		fn3	1156..1244	CDD:278470	30/92 (33%)
		fn3	1259..1346	CDD:278470	22/102 (22%)
CNTN6	NP_001276009.1	Ig	26..118	CDD:325142	35/102 (34%)
		Ig	120..214	CDD:325142	31/93 (33%)
		Ig	227..315	CDD:325142	31/91 (34%)
		Ig	319..403	CDD:325142	25/88 (28%)
		Ig	424..496	CDD:325142	25/71 (35%)
		Ig	515..598	CDD:325142	20/86 (23%)
		FN3	598..691	CDD:238020	38/96 (40%)
		FN3	703..796	CDD:238020	28/96 (29%)
		FN3	805..898	CDD:238020	31/99 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..908		6/20 (30%)
		FN3	906..991	CDD:238020	22/98 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9318
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1415
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm41700
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3370
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870