DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cont and NFASC

DIOPT Version :9

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:XP_024310051.1 Gene:NFASC / 23114 HGNCID:29866 Length:1513 Species:Homo sapiens


Alignment Length:1104 Identity:263/1104 - (23%)
Similarity:446/1104 - (40%) Gaps:199/1104 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   350 LDINDMERIPRGPYF---VKQPNDTTFDVNKNRLI---NDVTLSCLANGYPTPSYTWYR-----E 403
            |.:.....||..|..   :.||...|....|:.::   :::.:.|.|.|.|.||:.|.|     .
Human   168 LSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 232

  Fly   404 VYVDDRLEYQKIDPLAQDRYTISGGNLII-----YEPKQALDQGAYHCVAENKFGRIRSESAHLN 463
            :..|.|:..::           ..|.|:|     ..|::.  :|.|.|.|.||||...|      
Human   233 IAKDPRVSMRR-----------RSGTLVIDFRSGGRPEEY--EGEYQCFARNKFGTALS------ 278

  Fly   464 FGFIMEFNLKRSAETSEMNWGK--------------SIFCDPPQHYPDVRYYWARDYFPNFVEED 514
                   |..|...:....|.|              ::.|:||...|....:|....... :.:|
Human   279 -------NRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQD 335

  Fly   515 QRVFVSRDGALYFSFIETVD-RANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKV 578
            :||....:|.||||.:...| :.:|||..:...:.|.:....|.|:|..|..|......| .|.:
Human   336 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN-HPDM 399

  Fly   579 FPEAPVA--------------------GDEIRLECMAFGYPIPSYNWTRQG--LPLQRNAYTINY 621
            :....||                    |.::.|||:|.|.|.|...|.::|  ||..:..:. |:
Human   400 YSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NF 463

  Fly   622 GRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFA 686
            .:.|.|.|.:..|:|||.|..:|...::..:|.:.::..|.:....|::|.....|...:|.|..
Human   464 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANG 528

  Fly   687 IPDANYTWYKNAERLD--PANINR----DRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFS 745
            .|.....|..|.|.|.  |.|.||    |..|.:|..::.:        |:|||...|:.....:
Human   529 NPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR--------AVYQCNTSNEHGYLLA 585

  Fly   746 SAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGS---GGHRRIL 807
            :|.:.||.:.|.... |....:..:....|.:.|....:|.|..:|.|:||  ||   ||:..:.
Human   586 NAFVSVLDVPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVY 647

  Fly   808 PSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEA 872
            .:|:|.|....::|:|||||:|:|..|..|:..|:.|....|....|..: |::....:.|.|..
Human   648 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQ-VARRGTTVQLECRV 711

  Fly   873 AFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTS 937
            ..|..|.:...|..:.|.|...:    |:..:.:.||:...:.||.|.|.||..:.:::..:|..
Human   712 KHDPSLKLTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAY 772

  Fly   938 VSI---------------EGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTN--- 984
            :::               :|.|..|..:::..:::....:.|:.|..|...|..|.:....:   
Human   773 LTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQ 837

  Fly   985 ---WNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTY 1046
               |:             :..:|.....:.|:.|:|:..|:|.|.|:|::|...||.||..|.|.
Human   838 PGVWH-------------DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS 889

  Fly  1047 EDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIE-------WASDEIK 1104
            ...|...|.:|.|.|.:..::.|||.|:.........:.|.|.|:.:...|       |.|..: 
Human   890 GAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV- 953

  Fly  1105 KQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTC 1169
                :|...|.:|       ||::|||.|..|||||.|..:.:|.||.|:.||.:......|||.
Human   954 ----VGQTPVYVP-------YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 1007

  Fly  1170 FNVTWQPIDMSRENIRGKLIGHRLKYWKTT--------HQEEDSVYYLSRTTRNWALIVGLQPDT 1226
            .::.|..:  ..:.::|:|..:|..||:.:        .|:.....:.....|  .::..|.|.:
Human  1008 ISLQWNRV--YSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLR--GVVSRLFPYS 1068

  Fly  1227 YYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGI---NPSTVRVVWRYVSPSQDEEP 1288
            .|.::::..|..|:||.||..|..|    |:..||:...:.:   |..|:.:.|.:  |......
Human  1069 NYKLEMVVVNGRGDGPRSETKEFTT----PEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNGI 1127

  Fly  1289 VEGYKVRIWESDQNMITANNTIVPIGQKL-ESYINNLT--------PGKSYNMRVLAYSNGGDG 1343
            :.||.::       .:..|.|  .:|::: |::..|.|        |...|...:.|.:..|.|
Human  1128 MIGYTLK-------YVAFNGT--KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..460 CDD:299845 28/114 (25%)
I-set 362..462 CDD:254352 28/115 (24%)
Ig 466..559 CDD:299845 23/107 (21%)
IG_like 584..657 CDD:214653 25/94 (27%)
IGc2 586..645 CDD:197706 21/60 (35%)
Ig 667..751 CDD:299845 23/89 (26%)
IG_like 676..751 CDD:214653 21/80 (26%)
IG_like 765..844 CDD:214653 26/81 (32%)
Ig 773..844 CDD:299845 26/73 (36%)
I-set 851..940 CDD:254352 19/88 (22%)
Ig 866..944 CDD:299845 18/92 (20%)
FN3 944..1043 CDD:238020 22/104 (21%)
FN3 1053..1146 CDD:238020 29/99 (29%)
fn3 1156..1244 CDD:278470 20/95 (21%)
fn3 1259..1346 CDD:278470 19/97 (20%)
NFASCXP_024310051.1 Ig_hNeurofascin_like 208..284 CDD:143283 25/101 (25%)
Ig 289..381 CDD:325142 21/92 (23%)
Ig3_L1-CAM_like 430..500 CDD:319298 22/70 (31%)
Ig 517..592 CDD:325142 21/82 (26%)
Ig 615..681 CDD:319273 24/67 (36%)
I-set 694..775 CDD:254352 19/85 (22%)
FN3 794..884 CDD:238020 21/102 (21%)
FN3 895..985 CDD:238020 29/101 (29%)
FN3 994..1093 CDD:238020 23/102 (23%)
FN3 1098..1189 CDD:238020 19/96 (20%)
fn3 1287..1359 CDD:306538
Bravo_FIGEY 1405..1489 CDD:316405
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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