DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Cntn2

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_796103.2	Gene:	Cntn2 / 21367	MGIID:	104518	Length:	1040	Species:	Mus musculus

Alignment Length:	1036	Identity:	318/1036 - (30%)
Similarity:	495/1036 - (47%)	Gaps:	96/1036 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425
            ||.|.:||....|.  :....:.|||:|.|...|..:|.|        ::...:::.....|:.:
Mouse    38 GPVFEEQPVGLLFP--EESAEDQVTLACRARASPPATYRW--------KMNGTEMNLEPGSRHQL 92

  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNL-KRSAETSEMNWGKSIFC 489
            .||||:|..|.:|.|.|.|.|:|.|..|.:.|:.|.|.|||:.||:. :|....:...||..:.|
Mouse    93 MGGNLVIMSPTKAQDAGVYQCLASNPVGTVVSKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPC 157

  Fly   490 DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVDRANYSCTVQTLVSDTGRNG 553
            :||.|||.:.|.|..:.||||:..|.|.|||: .|.||.:.....|..|||| :.|...|.....
Mouse   158 NPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSC-LATSHLDFSTKS 221

  Fly   554 PFFPLRVTPNSNYQALIFANTFPKVF---------PEA-PVAGDEIRLECMAFGYPIPSYNWTRQ 608
            .|        |.:..|..|...|::|         ||. .:.|.::.|||.|||.|:|...|.:.
Mouse   222 VF--------SKFAQLNLAAEDPRLFAPSIKARFPPETYALVGQQVTLECFAFGNPVPRIKWRKV 278

  Fly   609 GLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNP--RKTLMKSIYINIQMRPQFTIPLKDMI 671
            ...|.....|..  ..|.|.:.:..|.|.|.|...|.  |.|:...|.  :|.:|::...:.|..
Mouse   279 DGSLSPQWGTAE--PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRII--VQAQPEWLKVISDTE 339

  Fly   672 KDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKD-KDDAMYQCG 735
            .|..|::.:.|.|...|.....|.:|.|.|  |:.||...:..|    ::|.:.: :|..||||.
Mouse   340 ADIGSNLRWGCAAAGKPRPMVRWLRNGEPL--ASQNRVEVLAGD----LRFSKLNLEDSGMYQCV 398

  Fly   736 AQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGS 800
            |:|:..|.::||:|.|.::.|.|:::|:...:.|...|..:|.|.|.|||:....|.|..:::|:
Mouse   399 AENKHGTIYASAELAVQALAPDFRQNPVRRLIPAARGGEISIPCQPRAAPKATILWSKGTEILGN 463

  Fly   801 GGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDL 865
            .....:...|||.|...||.|||.|||.|.|..|...| ..::.:::...|...|........|.
Mouse   464 STRVTVTLDGTLIIRNISRSDEGKYTCFAENFMGKANS-TGILSVRDATKITLAPSSADINVGDN 527

  Fly   866 IFLHCEAAFDELLDIAYVW----------KHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGD 920
            :.|.|.|:.|..:|:.:.|          |..|...:.:...|   |.|   ||:.|..:|..|.
Mouse   528 LTLQCHASHDPTMDLTFTWTLDDFPVDFDKPGGHYRRASVKET---IGD---LTILNAQLRHGGT 586

  Fly   921 YECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNW 985
            |.|:.::.|:..|.:.:|.:.|.||.||||.|..|..|...:.|..|..|...|..|.:..||..
Mouse   587 YTCMAQTVVDGASKEATVLVRGPPGPPGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQARTPP 651

  Fly   986 NRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKP 1050
            :..|..|.|:    .|:...:.:.|:|:.|.||..|||.|:|.|.||.|.||.||....|.|..|
Mouse   652 SGKWKQVRTN----PVNIEGNAETAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSRIRTKEAVP 712

  Fly  1051 YIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVN 1115
            .:||..:.||||..|:|||.|.|:..:.|:..|..|.:.::.:|:..|.:..:...|.......|
Mouse   713 SVAPSGLSGGGGAPGELTINWTPMSREYQNGDGFGYLLSFRRQGSSSWQTARVPGADTQYFVYSN 777

  Fly  1116 IPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMS 1180
            ..::. ||.:|||:::.|..|.||||..|:::|||:.|:|||.|..|...:|:..||:|:|:
Mouse   778 DSIHP-YTPFEVKIRSYNRRGDGPESLTAIVYSAEEEPKVAPAKVWAKGSSSSEMNVSWEPV--- 838

  Fly  1181 RENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESE 1245
            .:::.|.|:|:.::|||...:|..:....:....:.|.:.||.|:|.|.|.|.|||.||.||.|.
Mouse   839 LQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDSSARVTGLYPNTKYHVTVRAYNRAGTGPASP 903

  Fly  1246 RFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQN-----MIT 1305
            ..:..|.:..|::||.::. :..:.|::.:.|..|.|.::|..|.|||: ::::|..     .:|
Mouse   904 SADAMTMKPPPRRPPGNIS-WTFSSSSLSLKWDPVVPLRNESTVTGYKM-LYQNDLQPTPMLHLT 966

  Fly  1306 ANNTI-VPIGQKL-ESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNGANT 1364
            :.|.| :|:.:.: .:.:...|.|.           ||||..:.  :|.     .|||..:
Mouse   967 SKNWIEIPVPEDIGHALVQIRTTGP-----------GGDGIPAE--VHI-----VRNGGTS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	30/98 (31%)
		I-set	362..462	CDD:254352	30/99 (30%)
		Ig	466..559	CDD:299845	34/94 (36%)
		IG_like	584..657	CDD:214653	22/74 (30%)
		IGc2	586..645	CDD:197706	18/58 (31%)
		Ig	667..751	CDD:299845	26/84 (31%)
		IG_like	676..751	CDD:214653	24/75 (32%)
		IG_like	765..844	CDD:214653	27/78 (35%)
		Ig	773..844	CDD:299845	26/70 (37%)
		I-set	851..940	CDD:254352	24/98 (24%)
		Ig	866..944	CDD:299845	22/87 (25%)
		FN3	944..1043	CDD:238020	38/98 (39%)
		FN3	1053..1146	CDD:238020	31/92 (34%)
		fn3	1156..1244	CDD:278470	31/87 (36%)
		fn3	1259..1346	CDD:278470	22/93 (24%)
Cntn2	NP_796103.2	Ig	38..131	CDD:386229	32/102 (31%)
		Ig2_Contactin-2-like	133..230	CDD:143204	35/105 (33%)
		Ig	241..326	CDD:386229	24/88 (27%)
		Ig4_Contactin-2-like	330..414	CDD:143205	26/89 (29%)
		Ig5_Contactin	435..507	CDD:319278	26/72 (36%)
		Ig	526..605	CDD:386229	21/84 (25%)
		FN3	620..707	CDD:238020	31/90 (34%)
		FN3	728..808	CDD:238020	24/80 (30%)
		Cell attachment site. /evidence=ECO:0000255	796..798		0/1 (0%)
		FN3	817..909	CDD:238020	32/94 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..922		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9267
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1379
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm43749
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730