DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and rig-3

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	93/439 - (21%)
Similarity:	152/439 - (34%)	Gaps:	117/439 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 RDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFP------KVF 579
            |..:|:||.:.|.|...|:||.:|                ....|::..|.....|      |..
Worm   105 RKTSLHFSSVHTRDTGLYTCTGRT----------------AGGENFEKTIKLVVLPAIEWNDKDT 153

  Fly   580 PEAPVAGDEIRLECMAFGYPI---PSYNWTR-QGLPLQRNAYTINYGRVLIIQNATTNDNGE--Y 638
            .:..:.|:.|.::|...| |.   |....|. .|.||....:||......|  ::...::.|  .
Worm   154 VKGALLGEPITIDCGVKG-PSGKEPMIQMTNGNGEPLDEEIWTIAGNEATI--DSLKKEHAELTV 215

  Fly   639 SC-TITNPRKTL--------MKSIYINIQMRPQFTIPLK---DMIKDYNSDVTFIC---EAFAIP 688
            || ||...::|.        .|.:.|.:...|:|.....   .:|.::..|....|   .:|. |
Worm   216 SCITIEMHQETSKEEFPVVDRKDVNIEVYTLPEFETEESVQYTVIDNHVRDAIIYCNVTHSFP-P 279

  Fly   689 DANYTWYKNAERL---DPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLR 750
            ..:||:|...|.:   |..||..:..:.|...|.|..: .:.|...|:|.|.|....|:.:..||
Worm   280 VRHYTFYHGDEEIKMSDKFNIFVNVGVSQGAHLKIHNV-NENDLGTYKCEANNIKAKSYHTIHLR 343

  Fly   751 VLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTIS 815
            ..:.       |.|.:|..:.:...:|:...|:..|       |..:..:....|.|.:||...|
Worm   344 EANA-------PAEPKVTLIEDKRHSIIWKVESIDR-------DPDLPMTAVEIRHLRAGTAEAS 394

  Fly   816 PTSRDDEGIYTCIASNQAGTD---ESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDEL 877
            ..|  ||.|          :|   :||:                         ||:......|.:
Worm   395 GVS--DEDI----------SDAYWKSHS-------------------------IFMQRNIKDDGI 422

  Fly   878 LDI-------AYVWKHNGEVLKNNHDGTG-RIIVDWNRLTVHNTSMRDA 918
            .:|       .|||:..    :.|..|.| .:::....|..|:..|.|:
Worm   423 YEINGLRHGHEYVWRFR----QINEAGFGDSVVLRAKTLDDHDLEMMDS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845
		I-set	362..462	CDD:254352
		Ig	466..559	CDD:299845	10/37 (27%)
		IG_like	584..657	CDD:214653	21/87 (24%)
		IGc2	586..645	CDD:197706	18/65 (28%)
		Ig	667..751	CDD:299845	22/92 (24%)
		IG_like	676..751	CDD:214653	21/80 (26%)
		IG_like	765..844	CDD:214653	17/81 (21%)
		Ig	773..844	CDD:299845	16/73 (22%)
		I-set	851..940	CDD:254352	14/76 (18%)
		Ig	866..944	CDD:299845	14/61 (23%)
		FN3	944..1043	CDD:238020
		FN3	1053..1146	CDD:238020
		fn3	1156..1244	CDD:278470
		fn3	1259..1346	CDD:278470
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	12/52 (23%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	19/75 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100