DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and L1cam

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_032504.3	Gene:	L1cam / 16728	MGIID:	96721	Length:	1259	Species:	Mus musculus

Alignment Length:	1106	Identity:	269/1106 - (24%)
Similarity:	474/1106 - (42%)	Gaps:	199/1106 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 LFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLI----N 382
            |.:|...:|       |::.|:...|:.|:         .|...:|        :..||:    :
Mouse    11 LLLCSPCLL-------IQIPDEYKGHHVLE---------PPVITEQ--------SPRRLVVFPTD 51

  Fly   383 DVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLA--------QDRYTISGGNLIIYEPKQAL 439
            |::|.|.|.|.|...:.|.:     |.:.::..:.|.        ...:||.|.|.....
Mouse    52 DISLKCEARGRPQVEFRWTK-----DGIHFKPKEELGVVVHEAPYSGSFTIEGNNSFAQR----- 106

  Fly   440 DQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAET---SEMNWGKSIF--CDPPQHYPDVR 499
            .||.|.|.|.||.|...|....|    :.|...|...||   .|:..|:|:.  |:||.....:|
Mouse   107 FQGIYRCYASNKLGTAMSHEIQL----VAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAAPLR 167

  Fly   500 YYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSCT-----VQTLVSDTGRNGPFFPL 558
            .||......: :::|:||.:.::|.|||:.:.|.| .::|.|.     .:|::    :..| ..|
Mouse   168 IYWMNSKILH-IKQDERVSMGQNGDLYFANVLTSDNHSDYICNAHFPGTRTII----QKEP-IDL 226

  Fly   559 RVTPNSNY----QALIF-ANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQG--LPLQRNA 616
            ||.|.::.    ..|:| .|:..::   ..:.|..:.|||:|.|:|.|:..|....  :|..|..
Mouse   227 RVKPTNSMIDRKPRLLFPTNSSSRL---VALQGQSLILECIAEGFPTPTIKWLHPSDPMPTDRVI 288

  Fly   617 YTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFI 681
            |. |:.:.|.:.|....|:|||:|...|...:...:.|:.::..|.:....:..:..........
Mouse   289 YQ-NHNKTLQLLNVGEEDDGEYTCLAENSLGSARHAYYVTVEAAPYWLQKPQSHLYGPGETARLD 352

  Fly   682 CEAFAIPDANYTWYKNAERLDPANINRD-RYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFS 745
            |:....|....||..|...::  .:|:| :|.|:...|.:..:: ..|..:.||.|:||.....:
Mouse   353 CQVQGRPQPEITWRINGMSME--TVNKDQKYRIEQGSLILSNVQ-PSDTMVTQCEARNQHGLLLA 414

  Fly   746 SAQLRVLSMKPSFKKHPLESEVYAVYNGNTT-IVCDPEAAPRPKFQW-KKDGQVIGSGGHRRILP 808
            :|.:.|:.:.......  :::.|....|:|. ::|....||.|..|| .::|..:..  ..|..|
Mouse   415 NAYIYVVQLPARILTK--DNQTYMAVEGSTAYLLCKAFGAPVPSVQWLDEEGTTVLQ--DERFFP 475

  Fly   809 --SGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIV---LQEIRFIETPPQRIVSKEHDLIFL 868
              :|||:|.....:|.|.|.|    ||..|:::..::.   ::|...|...|:..:.|:...:..
Mouse   476 YANGTLSIRDLQANDTGRYFC----QAANDQNNVTILANLQVKEATQITQGPRSAIEKKGARVTF 536

  Fly   869 HCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEIS 933
            .|:|:||..|..:..|:.:|..|:...|.....|.| .:|.:.:....|.|:|.||..:.::|:.
Mouse   537 TCQASFDPSLQASITWRGDGRDLQERGDSDKYFIED-GKLVIQSLDYSDQGNYSCVASTELDEVE 600

  Fly   934 SKTSVSIEGAPGAPGGVQVIQ---ISKTKAIIEWVDGSHNGRAIRYYNI--------------LG 981
            |:..:.:.|:||....:::..   :.:::..:.|.....:...|..|:|              ||
Mouse   601 SRAQLLVVGSPGPVPHLELSDRHLLKQSQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEKWFSLG 665

  Fly   982 RTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTY 1046
            :...|:|                     :..:.|:|:..|.|.|||:|..|.|.||..|....|.
Mouse   666 KVPGNQT---------------------STTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTP 709

  Fly  1047 EDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGV 1111
            |..|...|.:|.|.|.:..::.|||.||...:.::..|.|:|.|:.:|          ||:....
Mouse   710 EAAPEKNPVDVRGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPQG----------KQETWRE 764

  Fly  1112 AVVNIPL-----NNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFN 1171
            ..|:.|.     .:.:..||:||||:|:.|||||.::.:.:|.||.|||:|:......:||:...
Mouse   765 QTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDYPQVSPELEDITIFNSSTVL 829

  Fly  1172 VTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYL--------SRTTRNWALIVGLQPDTYY 1228
            |.|:|:|:::  ::|.|.|:.:.||....|.:.|..::        :.||.  |::.||:|.:.|
Mouse   830 VRWRPVDLAQ--VKGHLKGYNVTYWWKGSQRKHSKRHIHKSHIVVPANTTS--AILSGLRPYSSY 890

  Fly  1229 FVKVMAYNAAGEGPESERFEERTYRKAPQKP--PSSVHVYGINPSTVRVVWR-----------YV 1280
            .|:|.|:|..|.||.|    |.|:......|  |.::|:...:.:::.:.|:           |:
Mouse   891 HVEVQAFNGRGLGPAS----EWTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSHNGVLTGYL 951

  Fly  1281 SPSQDEEPVEG-YKVRIW--ESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGD 1342
               ....|||| .|.:::  .||..:.|.|             :.||.|...|..::.|.:..|.
Mouse   952 ---LSYHPVEGESKEQLFFNLSDPELRTHN-------------LTNLNPDLQYRFQLQATTQQGP 1000

  Fly  1343 G 1343
            |
Mouse  1001 G 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	26/110 (24%)
		I-set	362..462	CDD:254352	26/111 (23%)
		Ig	466..559	CDD:299845	26/103 (25%)
		IG_like	584..657	CDD:214653	22/74 (30%)
		IGc2	586..645	CDD:197706	20/60 (33%)
		Ig	667..751	CDD:299845	17/84 (20%)
		IG_like	676..751	CDD:214653	17/75 (23%)
		IG_like	765..844	CDD:214653	23/82 (28%)
		Ig	773..844	CDD:299845	22/74 (30%)
		I-set	851..940	CDD:254352	22/88 (25%)
		Ig	866..944	CDD:299845	20/77 (26%)
		FN3	944..1043	CDD:238020	23/115 (20%)
		FN3	1053..1146	CDD:238020	30/97 (31%)
		fn3	1156..1244	CDD:278470	28/95 (29%)
		fn3	1259..1346	CDD:278470	21/101 (21%)
L1cam	NP_032504.3	Ig_L1-CAM_like	53..130	CDD:319299	22/90 (24%)
		Ig	133..227	CDD:386229	25/99 (25%)
		Ig3_L1-CAM	259..329	CDD:143284	21/70 (30%)
		Ig	346..421	CDD:386229	17/77 (22%)
		IG_like	433..513	CDD:214653	23/85 (27%)
		Ig	518..607	CDD:386229	22/89 (25%)
		Cell attachment site. /evidence=ECO:0000255	553..555		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	562..564		0/1 (0%)
		FN3	611..708	CDD:238020	23/117 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..724		10/26 (38%)
		fn3	717..798	CDD:365830	28/90 (31%)
		fn3	824..904	CDD:365830	25/83 (30%)
		fn3	920..1002	CDD:365830	20/98 (20%)
		Bravo_FIGEY	1146..1231	CDD:372781
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1182..1209
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1228..1259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810