DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cont and DCC

DIOPT Version :10

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens


Alignment Length:1034 Identity:218/1034 - (21%)
Similarity:349/1034 - (33%) Gaps:324/1034 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 FVKQPNDTTFDVNKNRLINDVTLSCLA-NGYPTPSYTWYRE-----VYVDDRLEYQKIDPLAQDR 422
            |:.:|:|.......|     |.|.|.| :....|...|.::     :.:|:|            :
Human    42 FLSEPSDAVTMRGGN-----VLLDCSAESDRGVPVIKWKKDGIHLALGMDER------------K 89

  Fly   423 YTISGGNLII--------YEPKQALDQGAYHCVAE-NKFGRIRSESAHLNFGFIMEFNLKRSAET 478
            ..:|.|:|:|        ::|    |:|.|.|.|. ...|.|.|.:|.:.....:.|..:..:.|
Human    90 QQLSNGSLLIQNILHSRHHKP----DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVT 150

  Fly   479 SEMNWGKSIFCDP-PQHYPDVRYYWAR---DYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYS 539
            :.|.....:.|:. .:..|.:  :|.:   |..|  :..|.||.|...|||..|.::..|...|.
Human   151 AFMGDTVLLKCEVIGEPMPTI--HWQKNQQDLTP--IPGDSRVVVLPSGALQISRLQPGDIGIYR 211

  Fly   540 CTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAP-----VAGDEIRLECMAFGYP 599
            |:.:...|  .|.|....:|:..:......::       |.:.|     :.|.:..|||...|||
Human   212 CSARNPAS--SRTGNEAEVRILSDPGLHRQLY-------FLQRPSNVVAIEGKDAVLECCVSGYP 267

  Fly   600 IPSYNWTR--QGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQ 662
            .||:.|.|  :.:.|:...|::..|..|:|.|.|.:|:|.|:|.:|                   
Human   268 PPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVT------------------- 313

  Fly   663 FTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDK 727
                                            |||      .||:                    
Human   314 --------------------------------YKN------ENIS-------------------- 320

  Fly   728 DDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWK 792
                             :||:|.|| :.|.|..||  |.:||..:.:....|.....|.|...|.
Human   321 -----------------ASAELTVL-VPPWFLNHP--SNLYAYESMDIEFECTVSGKPVPTVNWM 365

  Fly   793 KDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQR 857
            |:|.|:....:.:|:....|.|....:.|||.|.|:|.|:||..::.|::||         |...
Human   366 KNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV---------PKPA 421

  Fly   858 IVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYE 922
            |.|.                                               :|..::.||     
Human   422 IPSS-----------------------------------------------SVLPSAPRD----- 434

  Fly   923 CVVKSAVNEISSKTSVSIEGAP--GAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNW 985
                 .|..:.|...|.:...|  .|.|.:|...:..::      :|.:..||:           
Human   435 -----VVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSR------EGDNRERAL----------- 477

  Fly   986 NRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKP 1050
            |.|               .....|..|.||.|.:.|.|.|.|.|:.|.|..|.|..: :|..:..
Human   478 NTT---------------QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKV-ATQPELQ 526

  Fly  1051 YIAP-RNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVF------------------WKLKGAI 1096
            ...| .|:.........:.|||:|  |...:.....|::|                  :||:|  
Human   527 VPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEG-- 587

  Fly  1097 EWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPI 1161
                  :||                :|||.::..|.|..|.|..::...:.:..|:|...||...
Human   588 ------LKK----------------FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVS 630

  Fly  1162 ALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDT 1226
            ....||....|:|.|.....:|  |.:.|:::::.|||.:.|....   .....|.|..||:..:
Human   631 LEVVNSRSIKVSWLPPPSGTQN--GFITGYKIRHRKTTRRGEMETL---EPNNLWYLFTGLEKGS 690

  Fly  1227 YYFVKVMAYNAAGEGPESERFEERT------YRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQD 1285
            .|..:|.|....|.||.|..:...|      ..:.|.: |||:||   .|.|..::..:..|...
Human   691 QYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQ-PSSLHV---RPQTNCIIMSWTPPLNP 751

  Fly  1286 EEPVEGYKVRIWESDQNMITANNTIVPIGQKLESY-INNLTPGKSYNMRVLAYSNGGDG 1343
            ...|.||.:..........|     |.:..|...| |..|.....|.:.:.|::|.|:|
Human   752 NIVVRGYIIGYGVGSPYAET-----VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEG 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..466 CDD:472250 26/116 (22%)
Ig strand B 384..388 CDD:409356 2/3 (67%)
Ig strand C 397..409 CDD:409356 2/16 (13%)
Ig strand E 428..432 CDD:409356 2/3 (67%)
Ig strand F 443..448 CDD:409356 2/4 (50%)
Ig strand G 457..460 CDD:409356 1/2 (50%)
Ig 474..559 CDD:472250 21/88 (24%)
Ig strand B 485..489 CDD:409392 0/3 (0%)
Ig strand C 499..503 CDD:409392 0/3 (0%)
Ig strand E 523..527 CDD:409392 3/3 (100%)
Ig strand F 537..542 CDD:409392 2/4 (50%)
Ig strand G 553..556 CDD:409392 1/2 (50%)
Ig_3 584..644 CDD:464046 22/61 (36%)
Ig_3 660..738 CDD:464046 5/77 (6%)
Ig 756..844 CDD:472250 27/87 (31%)
Ig strand B 775..779 CDD:409358 0/3 (0%)
Ig strand C 788..792 CDD:409358 0/3 (0%)
Ig strand E 810..814 CDD:409358 1/3 (33%)
Ig strand F 824..829 CDD:409358 2/4 (50%)
Ig strand G 837..840 CDD:409358 0/2 (0%)
Ig <868..944 CDD:472250 6/75 (8%)
Ig strand C 881..885 CDD:409359 0/3 (0%)
Ig strand E 906..910 CDD:409359 0/3 (0%)
Ig strand F 920..925 CDD:409359 0/4 (0%)
Ig strand G 933..936 CDD:409359 1/2 (50%)
FN3 944..1043 CDD:238020 23/100 (23%)
FN3 1053..1146 CDD:238020 21/111 (19%)
fn3 1156..1244 CDD:394996 24/87 (28%)
fn3 1259..1346 CDD:394996 22/86 (26%)
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 26/114 (23%)
Ig strand A 39..42 CDD:409387 218/1034 (21%)
Ig strand A' 45..51 CDD:409387 2/5 (40%)
Ig strand B 55..65 CDD:409387 5/14 (36%)
Ig strand C 70..76 CDD:409387 2/5 (40%)
Ig strand C' 78..81 CDD:409387 0/2 (0%)
Ig strand D 88..93 CDD:409387 1/16 (6%)
Ig strand E 95..101 CDD:409387 3/5 (60%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 4/10 (40%)
Ig_3 139..216 CDD:464046 19/80 (24%)
I-set 241..327 CDD:400151 33/186 (18%)
Ig strand B 257..261 CDD:409562 1/3 (33%)
Ig strand C 270..274 CDD:409562 1/3 (33%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 2/4 (50%)
Ig strand G 322..325 CDD:409562 2/2 (100%)
Ig 334..417 CDD:472250 25/84 (30%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 429..521 CDD:238020 28/134 (21%)
FN3 <478..901 CDD:442628 89/384 (23%)
FN3 946..1041 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152
Neogenin_C 1148..1445 CDD:461954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
Blue background indicates that the domain is not in the aligned region.

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