DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Chl1

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006505530.1	Gene:	Chl1 / 12661	MGIID:	1098266	Length:	1225	Species:	Mus musculus

Alignment Length:	1061	Identity:	289/1061 - (27%)
Similarity:	456/1061 - (42%)	Gaps:	123/1061 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 PYFVKQ-------PNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDP-- 417
            |..|||       |.|..|.:           .|.|.|.|.|.::|.:    ||: .:...||
Mouse    35 PTIVKQSYVQVAFPFDEYFQI-----------ECEAKGNPEPIFSWTK----DDK-PFDLSDPRI 83

  Fly   418 LAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEMN 482
            :|.:.   ||...|..|...:..||.|.|.|.|:.|...||........:.:|. |...|..::.
Mouse    84 IAANN---SGTFKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVPGVPKFP-KEKIEPIDVE 144

  Fly   483 WGKSIF--CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC---- 540
            .|.||.  |:||:..|.:..||......: :|:|:||::|:.|.|||:.:|..| |.:|.|
Mouse   145 EGDSIVLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQRGDLYFANVEENDSRNDYCCFAAF 208

  Fly   541 -TVQTLVSDTGRNGPFFPLRVTPN---------SNYQALIFANTF----PK-VFPEAPVA----- 585
             .::|:|..       .|:::|.|         |:.:....||:.    || :.|.|.:.
Mouse   209 PKLRTIVQK-------MPMKLTVNSLKHASDSSSSTEICSQANSIKQRKPKLLLPPAQMGSLSAK 266

  Fly   586 ----GDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTIN-YGRVLIIQNATTNDNGEYSCTITNP 645
                ||.:.|||.|.|.|.|...|::.|..|.....||. :.:.|.|:|.:..|.|.|.||..|.
Mouse   267 TVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENISYQDRGNYRCTANNL 331

  Fly   646 RKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLD----PANI 706
            ........::.::..|::....:..:....|....:|||...|.....|..|...::    |.:.
Mouse   332 LGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQPTIKWRLNGLPIEKHPFPGDF 396

  Fly   707 NRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVY 771
            ...|.|...|:|       .....:|||.|.|...|..::|.:.|:.:.|..|..  ..|.||..
Mouse   397 MFPREISFTNLL-------PNHTGVYQCEASNIHGTILANANIDVIDVIPLIKTK--NEENYATV 452

  Fly   772 NGNTTIV-CDPEAAPRPKFQWKKDGQVIGSGGHR-RILPSGTLTISPTSRDDEGIYTCIASNQAG 834
            .|.:..: |:..|:|:....|:...:.....|.| ....:|||.|..|:.:|.|.|:|...|..|
Mouse   453 VGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMG 517

  Fly   835 TDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELL--DIAYVWKHNGEVLKNNHDG 897
            .....|.:.:....:...:|....:.|.| ::.|:||:..|..|  .:...|..:||..:.|...
Mouse   518 KAVITANLDIRNATKLRVSPKNPRIPKSH-VLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTE 581

  Fly   898 TGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAII 962
            .|||::|...||:.|.:..|.|.|.|..:::::..|.||.|::.|.|..||.:.:.:.......:
Mouse   582 DGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLGVPDPPGNLHLSERQNRSVRL 646

  Fly   963 EWVDG-SHNGRAIRY-YNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSV 1025
            .|..| .||.:...| ....|.......|..: |.||..|.|        .|::|.|:..|:|.|
Mouse   647 SWEAGDDHNSKISEYIVEFEGNREEPGKWEEL-TRVQGEETD--------VVLSLAPYVRYQFRV 702

  Fly  1026 TAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFW 1090
            ||||::|....|.||..:.|....|...|:|:.....:..::.|.|:||...||:..|:.|||.|
Mouse   703 TAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYKVSW 767

  Fly  1091 KLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQV 1155
            |.:||.|...:||.....:.|....:     |..|:|||||||.:|..|:.:...::|.||.|..
Mouse   768 KPQGAPEEWEEEIVTNHTLRVMTPTV-----YAPYDVKVQAINQLGSSPDPQPVTLYSGEDYPST 827

  Fly  1156 APQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKT-------THQEEDSVYYLSRTT 1213
            ||........|||...|||..|  .:|.:.|.|.|:::.:|||       ||.:|.::...| ..
Mouse   828 APVIQRVDVMNSTLVKVTWSSI--PKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFS-GQ 889

  Fly  1214 RNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWR 1278
            ||..::..|.|.:.:.:.|:|||:.|.|||||.:..:|....|:: ||.:.|..::..|..:.|.
Mouse   890 RNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PSFLKVIKVDKDTATLSWG 953

  Fly  1279 YVSPSQDEEPVEGY--KVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGG 1341
            .  |.:....:.||  :.:|......:...|...|....|...:::||.....|...:.|.::.|
Mouse   954 L--PKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYKFYLRACTSRG 1016

  Fly  1342 DGRMSSPTLHFQMGKTTRNGA 1362
            .|:..|     :.|.|...|:
Mouse  1017 CGKPIS-----EEGATLGEGS 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	31/106 (29%)
		I-set	362..462	CDD:254352	31/108 (29%)
		Ig	466..559	CDD:299845	29/100 (29%)
		IG_like	584..657	CDD:214653	23/82 (28%)
		IGc2	586..645	CDD:197706	22/59 (37%)
		Ig	667..751	CDD:299845	19/87 (22%)
		IG_like	676..751	CDD:214653	19/78 (24%)
		IG_like	765..844	CDD:214653	22/80 (28%)
		Ig	773..844	CDD:299845	19/72 (26%)
		I-set	851..940	CDD:254352	27/90 (30%)
		Ig	866..944	CDD:299845	25/79 (32%)
		FN3	944..1043	CDD:238020	29/100 (29%)
		FN3	1053..1146	CDD:238020	31/92 (34%)
		fn3	1156..1244	CDD:278470	31/94 (33%)
		fn3	1259..1346	CDD:278470	18/88 (20%)
Chl1	XP_006505530.1	Ig	35..126	CDD:416386	31/109 (28%)
		Ig strand A	35..39	CDD:409353	1/3 (33%)
		Ig strand A'	44..48	CDD:409353	0/3 (0%)
		Ig strand B	53..60	CDD:409353	2/17 (12%)
		Ig strand C	66..71	CDD:409353	1/4 (25%)
		Ig strand C'	74..76	CDD:409353	0/2 (0%)
		Ig strand D	82..85	CDD:409353	0/2 (0%)
		Ig strand E	90..94	CDD:409353	1/3 (33%)
		Ig strand F	105..113	CDD:409353	4/7 (57%)
		Ig strand G	116..126	CDD:409353	3/9 (33%)
		IgI_2_L1-CAM_like	135..225	CDD:409432	29/97 (30%)
		Ig strand B	149..153	CDD:409432	1/3 (33%)
		Ig strand C	163..167	CDD:409432	1/3 (33%)
		Ig strand E	186..190	CDD:409432	2/3 (67%)
		Ig strand F	201..206	CDD:409432	2/4 (50%)
		Ig strand G	217..220	CDD:409432	0/9 (0%)
		Ig	262..344	CDD:416386	23/81 (28%)
		Ig strand B	274..278	CDD:409353	1/3 (33%)
		Ig strand C	287..291	CDD:409353	0/3 (0%)
		Ig strand E	309..313	CDD:409353	1/3 (33%)
		Ig strand F	323..328	CDD:409353	2/4 (50%)
		Ig strand G	336..339	CDD:409353	0/2 (0%)
		Ig4_L1-NrCAM_like	348..435	CDD:409367	19/93 (20%)
		Ig strand B	364..368	CDD:409367	0/3 (0%)
		Ig strand C	377..381	CDD:409367	0/3 (0%)
		Ig strand E	400..404	CDD:409367	2/3 (67%)
		Ig strand F	414..419	CDD:409367	3/4 (75%)
		Ig strand G	427..430	CDD:409367	0/2 (0%)
		Ig	448..525	CDD:416386	21/76 (28%)
		Ig strand A'	448..452	CDD:409353	2/3 (67%)
		Ig strand B	455..464	CDD:409353	1/8 (13%)
		Ig strand C	470..475	CDD:409353	1/4 (25%)
		Ig strand C'	478..481	CDD:409353	0/2 (0%)
		Ig strand D	486..491	CDD:409353	1/4 (25%)
		Ig strand E	492..499	CDD:409353	4/6 (67%)
		Ig strand F	506..514	CDD:409353	3/7 (43%)
		Ig strand G	517..525	CDD:409353	2/7 (29%)
		Ig strand A	529..535	CDD:409353	0/5 (0%)
		Ig strand A'	538..543	CDD:409353	0/4 (0%)
		Ig strand B	546..554	CDD:409353	3/8 (38%)
		IG_like	548..624	CDD:214653	24/75 (32%)
		Ig strand C	565..569	CDD:409353	0/3 (0%)
		Ig strand D	584..587	CDD:409353	2/2 (100%)
		Ig strand E	588..594	CDD:409353	2/5 (40%)
		Ig strand F	603..610	CDD:409353	3/6 (50%)
		Ig strand G	617..621	CDD:409353	2/3 (67%)
		FN3	628..717	CDD:238020	27/97 (28%)
		fn3	731..811	CDD:394996	30/84 (36%)
		FN3	833..927	CDD:238020	32/96 (33%)
		FN3	932..1027	CDD:238020	21/102 (21%)
		Bravo_FIGEY	1121..1202	CDD:404722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11990
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810