DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Nfasc

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006249789.1	Gene:	Nfasc / 116690	RGDID:	620911	Length:	1469	Species:	Rattus norvegicus

Alignment Length:	1114	Identity:	269/1114 - (24%)
Similarity:	452/1114 - (40%)	Gaps:	204/1114 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 LDINDMERIPRGPYF---VKQPNDTTFDVNKNRLI---NDVTLSCLANGYPTPSYTWYR-----E 403
            |.:.....||..|..   :.||...|....|:.::   :::.:.|.|.|.|.||:.|.|     .
  Rat   124 LSLGGAIEIPMDPSIQNELTQPPTITKQSVKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 188

  Fly   404 VYVDDRLEYQKIDPLAQDRYTISGGNLII-----YEPKQALDQGAYHCVAENKFGRIRSESAHLN 463
            :..|.|:..::           ..|.|:|     ..|::.  :|.|.|.|.||||...|
  Rat   189 IAKDPRVSMRR-----------RSGTLVIDFRSGGRPEEY--EGEYQCFARNKFGTALS------ 234

  Fly   464 FGFIMEFNLKRSAETSEMNWGK--------------SIFCDPPQHYPDVRYYWARDYFPNFVEED 514
                   |..|...:....|.|              ::.|:||...|....:|....... :.:|
  Rat   235 -------NRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQD 291

  Fly   515 QRVFVSRDGALYFSFIETVD-RANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKV 578
            :||....:|.||||.:...| :.:|||..:...:.|.:....|.|:|..|:.|......| .|.:
  Rat   292 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNNPYNDSSLRN-HPDI 355

  Fly   579 FPEAPVA--------------------GDEIRLECMAFGYPIPSYNWTRQG--LPLQRNAYTINY 621
            :....||                    |.::.|||:|.|.|.|...|.::|  ||..:..:. |:
  Rat   356 YSARGVAERTPSFMYPQGTSSSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NF 419

  Fly   622 GRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFA 686
            .:.|.|.|.:..|:|||.|..:|...::..:|.:.::..|.:....|::|.....|...:|.|..
  Rat   420 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANG 484

  Fly   687 IPDANYTWYKNAERLD--PANINR----DRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFS 745
            .|.....|..|.:.|.  |.|.||    |..|.:|..::.:        |:|||...|:.....:
  Rat   485 NPKPTVQWLVNGDPLQSAPPNPNREVAGDTIIFRDTQISSR--------AVYQCNTSNEHGYLLA 541

  Fly   746 SAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGS---GGHRRIL 807
            :|.:.||.:.|.... |....:..:....|.:.|....:|.|..:|.|:||  ||   ||:..:.
  Rat   542 NAFVSVLDVPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVY 603

  Fly   808 PSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEA 872
            .:|:|.|....::|:|||||:|:|..|..|:..|:.|....|....|..: |:|....:.|.|..
  Rat   604 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQ-VAKRGTTVQLECRV 667

  Fly   873 AFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTS 937
            ..|..|.:...|..:.|.|...:    |:..:.:.||:...:.||.|.|.|:..:.:::..:|..
  Rat   668 KHDPSLKLTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQGSYTCMASTELDQDLAKAY 728

  Fly   938 VSI---------------EGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTN--- 984
            :::               :|.|..|..:::..:::....:.|:.|..|...|..|.:....:
  Rat   729 LTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYVVQFEEDQFQ 793

  Fly   985 ---WNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTY 1046
               |:             :..::.....:.|::|:|:..|:|.|.|||::|...||.||..|.|.
  Rat   794 PGVWH-------------DHSKFPGSVNSAVLHLSPYVNYQFRVIAVNEVGSSHPSLPSERYRTS 845

  Fly  1047 EDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIE-------WASDEIK 1104
            ...|...|.:|.|.|.:..::.|||.|:.........:.|.|.|:.:...|       |.|..:
  Rat   846 GAPPESNPSDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETRETWNNVTVWGSRYV- 909

  Fly  1105 KQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTC 1169
                :|...|.:|       ||::|||.|..|||||.|..:.:|.||.|:.||.:......|||.
  Rat   910 ----VGQTPVYVP-------YEIRVQAENDFGKGPEPETVIGYSGEDYPRAAPTEVKIRVLNSTA 963

  Fly  1170 FNVTWQPIDMSRENIRGKLIGHRLKYWKTT--------HQEEDSVYYLSRTTRNWALIVG-LQPD 1225
            .::.|..:  ..:.::|:|..:|..||:.:        .|:.....:.....|.   :|| |.|.
  Rat   964 ISLQWNRV--YSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRPRG---VVGRLFPY 1023

  Fly  1226 TYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGI---NPSTVRVVWRYVSPSQDEE 1287
            :.|.::::..|..|:||.||..|..|    |:..||:...:.:   |..|:.:.|.:  |.....
  Rat  1024 SNYKLEMVVVNGRGDGPRSETKEFTT----PEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNG 1082

  Fly  1288 PVEGYKVRIWESDQNMITANNTIVPIG-QKLESYINNLT--------PGKSYNMRVLAYSNGGDG 1343
            .:.||.:|       .:..|.|  .:| |.:|::..|.|        |...|...:.|.:..|.|
  Rat  1083 ILIGYTLR-------YVPFNGT--KLGKQMVENFSPNQTKFSVQRADPVSRYRFSLSARTQVGSG 1138

  Fly  1344 RMS---SPT 1349
            ..:   |||
  Rat  1139 EAATEESPT 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/114 (25%)
		I-set	362..462	CDD:254352	28/115 (24%)
		Ig	466..559	CDD:299845	23/107 (21%)
		IG_like	584..657	CDD:214653	25/94 (27%)
		IGc2	586..645	CDD:197706	21/60 (35%)
		Ig	667..751	CDD:299845	22/89 (25%)
		IG_like	676..751	CDD:214653	20/80 (25%)
		IG_like	765..844	CDD:214653	26/81 (32%)
		Ig	773..844	CDD:299845	26/73 (36%)
		I-set	851..940	CDD:254352	19/88 (22%)
		Ig	866..944	CDD:299845	17/92 (18%)
		FN3	944..1043	CDD:238020	22/104 (21%)
		FN3	1053..1146	CDD:238020	29/99 (29%)
		fn3	1156..1244	CDD:278470	22/96 (23%)
		fn3	1259..1346	CDD:278470	21/98 (21%)
Nfasc	XP_006249789.1	IG_like	154..241	CDD:214653	26/112 (23%)
		Ig6_hNeurofascin_like	164..240	CDD:143283	25/101 (25%)
		Ig	245..337	CDD:299845	21/92 (23%)
		IG_like	254..338	CDD:214653	20/84 (24%)
		IG_like	375..455	CDD:214653	23/80 (29%)
		Ig3_L1-CAM_like	386..456	CDD:143208	22/70 (31%)
		I-set	459..547	CDD:254352	23/95 (24%)
		Ig	473..548	CDD:299845	20/82 (24%)
		IGc2	571..630	CDD:197706	22/60 (37%)
		I-set	650..731	CDD:254352	19/85 (22%)
		Ig	663..731	CDD:299845	16/71 (23%)
		FN3	750..840	CDD:238020	21/102 (21%)
		FN3	851..941	CDD:238020	29/101 (29%)
		FN3	950..1049	CDD:238020	25/103 (24%)
		FN3	1054..1147	CDD:238020	22/103 (21%)
		fn3	1244..1315	CDD:278470
		Bravo_FIGEY	1361..1445	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810