DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Cntn4

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_446331.1	Gene:	Cntn4 / 116658	RGDID:	621361	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	1052	Identity:	317/1052 - (30%)
Similarity:	487/1052 - (46%)	Gaps:	83/1052 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425
            ||.||::|:...|.::...  ..|.|||...|.|.|...|        :|....:|.....||::
  Rat    25 GPVFVQEPSHVMFPLDSEE--KKVKLSCEVKGNPKPHIRW--------KLNGTDVDIGMDFRYSV 79

  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWGKSIFC 489
            ..|:|:|..|.:..|.|.|.|:|.|.||.|.|..|.|.|.::..|..: ||..:.....|..:.|
  Rat    80 VEGSLLINNPNKTQDSGTYQCIATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLC 144

  Fly   490 DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSDTGRNG 553
            .||.|..::.|.|..:..|::  :|.|.|||:: |.||.:.:|..|..||:|.|...|:.....|
  Rat   145 GPPPHSGELSYAWIFNEHPSY--QDNRRFVSQETGNLYIAKVEKADVGNYTCVVTNTVTSHQVLG 207

  Fly   554 PFFPLRVTPNSNYQALIFANTFPKV---FPEAPVA--GDEIRLECMAFGYPIPSYNWTR-QGLPL 612
            |..|| :..|..    :.....||:   |||...|  |..::|||.|.|.|:|:..|.| .|.|:
  Rat   208 PPTPL-ILRNDG----VMGEYEPKIEVQFPETVPAEKGSTVKLECFALGNPVPTILWRRADGKPI 267

  Fly   613 QRNAYTINYGRVLIIQNATTNDNGEYSCTITNPR-KTLMKSIYINIQMRPQFTIPLKDMIKDYNS 676
            .|.|.......:|.|.|....|.|.|.|...|.| |.:.|. .:....:|.:...:.|:......
  Rat   268 ARKARRHKSSGILEIPNFQQEDAGSYECVAENSRGKNIAKG-QVTFYAQPNWVQIINDIHVAMEE 331

  Fly   677 DVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLK 741
            .|.:.|:|...|...|.|.||.:.|    :.|:|..|:...|.|..:.. .|..||||.|:|:..
  Rat   332 SVFWECKANGRPKPTYRWLKNGDPL----LTRERIQIEQGTLNITIVNL-SDAGMYQCVAENKHG 391

  Fly   742 TSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRI 806
            ..::||:|.|::..|.|.:..|:........|...|.|.|:|:|||.:.|:|..:::.......|
  Rat   392 VIYASAELSVIAESPDFSRTLLKRVTLVKVGGEVVIECKPKASPRPVYTWRKGREILRENERITI 456

  Fly   807 LPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCE 871
            ...|.|.|...::.|.|.|||||:|..||..|...|:|....: :..||..:.....:.|.|.|:
  Rat   457 SEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVVVKDPTK-VMVPPSSMDVTVGESIVLPCQ 520

  Fly   872 AAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNR---------LTVHNTSMRDAGDYECVVKS 927
            ...|..|||.:.|..||.::..:.||.     .:.|         |.:.|..::.||.|.|:|::
  Rat   521 VTHDHSLDIVFTWTFNGHLIDFDKDGD-----HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT 580

  Fly   928 AVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNV 992
            :|:::|:...:.:.|.||.|..|.:.:|:.|.|.:.|..|..|...|..|.|..||.::..|..|
  Rat   581 SVDKLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAV 645

  Fly   993 STHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNV 1057
            ||..:..:...:|    |.||.|.||..|||...|.|.:|||.||.||....|.|..|.:.|.||
  Rat   646 STVPELVDGKTFT----ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANV 706

  Fly  1058 GGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYY 1122
            .||||...:|.|||:.:..:.|:..|..|.|.::..|.:.|....:...|.......|..:.. :
  Rat   707 SGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPHGKMIWMLTVLASADASRYVFRNESVRP-F 770

  Fly  1123 TEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTW-QPIDMSRENIRG 1186
            :.:||||...|:.|:||.|...:::|||:.|...|....|.:.::|...|.| .||..:    ||
  Rat   771 SPFEVKVGVFNNKGEGPFSPTTLVYSAEEEPTKPPASIFARSLSATDIEVFWASPIGKN----RG 831

  Fly  1187 KLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERT 1251
            ::.|:.:|||:...:||::....:...:....|..|:.:..|.:.|.|||:||.||.|......|
  Rat   832 RIQGYEVKYWRHDDKEENARKIRTVGNQTSTKITNLKGNALYHLSVKAYNSAGTGPSSAAVNVTT 896

  Fly  1252 YRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRI-W--ESDQNMITANNTIVPI 1313
            .:..|.:||.:: ::..:.|.:.:.|..|....:|..|:||||.. |  :|..::|..|.|.|.:
  Rat   897 RKPPPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL 960

  Fly  1314 GQKL-ESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTR-----NGANTRHGHNINT 1372
            .... |.||..:.|          :|:||||..|.   ..::.|.:.     :||:|   .|..|
  Rat   961 SLPFDEDYIIEIKP----------FSDGGDGSSSE---QIRIPKISNSYARGSGAST---SNACT 1009

  Fly  1373 ALILSTLLLIST 1384
            ...:||:::..|
  Rat  1010 LSAISTIMISLT 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	32/98 (33%)
		I-set	362..462	CDD:254352	32/99 (32%)
		Ig	466..559	CDD:299845	29/94 (31%)
		IG_like	584..657	CDD:214653	26/76 (34%)
		IGc2	586..645	CDD:197706	21/59 (36%)
		Ig	667..751	CDD:299845	25/83 (30%)
		IG_like	676..751	CDD:214653	24/74 (32%)
		IG_like	765..844	CDD:214653	26/78 (33%)
		Ig	773..844	CDD:299845	26/70 (37%)
		I-set	851..940	CDD:254352	24/97 (25%)
		Ig	866..944	CDD:299845	23/86 (27%)
		FN3	944..1043	CDD:238020	38/98 (39%)
		FN3	1053..1146	CDD:238020	28/92 (30%)
		fn3	1156..1244	CDD:278470	26/88 (30%)
		fn3	1259..1346	CDD:278470	26/90 (29%)
Cntn4	NP_446331.1	Ig	25..114	CDD:299845	32/98 (33%)
		I-set	26..117	CDD:254352	32/100 (32%)
		Ig	120..213	CDD:299845	30/95 (32%)
		IG_like	130..204	CDD:214653	24/75 (32%)
		Ig	225..313	CDD:299845	31/88 (35%)
		IG_like	232..311	CDD:214653	28/79 (35%)
		I-set	316..401	CDD:254352	26/89 (29%)
		Ig	318..401	CDD:299845	25/87 (29%)
		IG_like	415..494	CDD:214653	26/78 (33%)
		Ig5_Contactin_like	422..494	CDD:143170	26/71 (37%)
		IG_like	504..593	CDD:214653	23/93 (25%)
		Ig6_Contactin-4	513..597	CDD:143261	23/88 (26%)
		FN3	597..690	CDD:238020	37/96 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		11/24 (46%)
		FN3	703..792	CDD:238020	28/89 (31%)
		FN3	804..896	CDD:238020	27/95 (28%)
		FN3	904..989	CDD:238020	27/98 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9086
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1297
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm45829
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840