DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Dscaml1

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	1317	Identity:	294/1317 - (22%)
Similarity:	473/1317 - (35%)	Gaps:	320/1317 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 NEDLHDNRFLVQNDLNNQNINNPNQFYNSL---PGTVNQRNQNNLRGFIG------PN--QPY-- 289
            |..:|||.:....:.....|.:||....::   |.||...:|.::||.:.      |:  |.|
Mouse    93 NSFIHDNDYFCTAENAAGKIRSPNIRIKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 157

  Fly   290 ------------GDNR---------YVRD----------RVV----YAFSKKRDRWMFM----PA 315
                        .:||         |:.|          |.:    |:...::.....:    ||
Mouse   158 VVSWEKDTVSITPENRFFITSHGGLYISDVQKEDALSTYRCITQHKYSGETRQSNGARLSVTDPA 222

  Fly   316 YEIELNLFICESKVLYSSDNVNIK-------------LDDKRPYH---------YGLDINDMERI 358
            ..|...|....|:.:::..:|.:.             |.|.||..         .||.|:|:...
Mouse   223 ESIPTILDGFHSQEVWTGHSVELPCAASGYPIPAIRWLKDGRPLPADSRWAKRITGLTISDLRTE 287

  Fly   359 PRGPYFVKQPNDTTF---DVN------------------KNRLINDVTLSCLANGYPTPSYTWYR 402
            ..|.|..:..|  ||   :.|                  |..:.:.|.|||...|.|..:..|||
Mouse   288 DSGTYICEVTN--TFGSAEANGILTVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYR 350

  Fly   403 EVYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFI 467
            ...:....|...|..|:.:...||..        |....|||.|.|..|     :::|. :|..|
Mouse   351 NTELVLPGEAISIRGLSNETLLISSA--------QKSHSGAYQCFATRK-----AQTAQ-DFAII 401

  Fly   468 -MEFNLKR---SAETSEMNWGK--SIFC----DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD 522
             :|....|   |.....:|.|:  |:.|    .||   |.|.  ||.|..|          |.||
Mouse   402 VLEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPP---PTVT--WALDDEP----------VVRD 451

  Fly   523 GALYFSFIETVDRAN-YSCTVQTLVSDTGRNGPFF----PLRVTP-----NSNYQALIFANTFPK 577
            |:         .|.| |:.:..|.:|.....||..    ..|.|.     ::.|||.|.....|.
Mouse   452 GS---------HRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNSVGSAEYQARINVRGPPS 507

  Fly   578 VFPE---APVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTN------ 633
            :...   ..|||.:..:.|...|||..|..|.:..|.|..|      .|.::.:|.|..
Mouse   508 IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN------HRQVVFENGTLKLTDVQK 566

  Fly   634 --DNGEYSCTI-TNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIP------- 688
              |.|||.|:: ..|:.::.:|:::.:::.|        :|:.:......|.:...||
Mouse   567 GMDEGEYLCSVLIQPQLSISQSVHVAVKVPP--------LIQPFEFPPASIGQLLYIPCVVSSGD 623

  Fly   689 -DANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLE----------KDKDDAMYQCGAQNQLKT 742
             ....||.|:.:           .||..:.:||:..|          ..|.:..|.|.|.|...|
Mouse   624 MPIRITWRKDGQ-----------VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT 677

  Fly   743 SFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSG------ 801
            .....|| ::.:.|.|...|...:  .:|.....:.|..:..|.||..||   ...|||
Mouse   678 VSRERQL-IVRVPPRFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKVMWK---HAKGSGNPQQYH 736

  Fly   802 -----GHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSK 861
                 |..:|||:.:|.|.....:|.|.|.|.|||..|||.|.|..:.::....|.:.|...::.
Mouse   737 PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMITSHPNTTIAI 801

  Fly   862 EHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGD------ 920
            :.....|:|.|..:..:.|.  |:            .|..::|.:|:..:..:.:|.||
Mouse   802 KGHPKELNCTARGERPIIIR--WE------------KGDTVIDPDRVMRYAIATKDNGDEVVSTL 852

  Fly   921 ------------YECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWV---DGSH- 969
                        :.|...::..|......::::..|..| .:::.::......:.|.   ||:.
Mouse   853 KLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSI 916

  Fly   970 -NGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGI 1033
             .|..|.|.|.....::.::..|:|..:           .||.:|:|.|.|.|...:.:.|.:|.
Mouse   917 ITGFDIEYKNKSDSWDFKQSTRNISPTI-----------NQANIVDLHPASVYSIRMYSFNKIGR 970

  Fly  1034 GTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHG------IHYK----- 1087
            ..||....| ||.|..|...|.:|.........:.:||.  .|:::..:|      |.|:
Mouse   971 SEPSKELTI-STEEAAPDGPPMDVTLQPVTSQSIQVTWK--APKKELQNGVIRGYQIGYRENSPG 1032

  Fly  1088 -------VFWKLKGAIE-WASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIA 1144
                   |..|..|..| :..|.:||                :.:|.|.|||.|..|.||.|...
Mouse  1033 SNGQYSIVEMKATGDSEVYTLDNLKK----------------FAQYGVVVQAFNRAGTGPSSSEI 1081

  Fly  1145 VIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYL 1209
            ...:.||:|...|:...||:..|....::|.  :..|..:.|.|.|:|:.:|......|......
Mouse  1082 NATTLEDVPSQPPENVRALSITSDVAVISWS--EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1144

  Fly  1210 SRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVR 1274
            ..|||....:.|::..|.|.|:|:||..||:|..|.....:|....| .||:.:.....:.|:|.
Mouse  1145 VTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVV 1208

  Fly  1275 VVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSN 1339
            |.|  :.|::....:..|.: ...|..:...|.:......::|...|.:|..|:.|.:.|.|.::
Mouse  1209 VSW--LPPTKPNGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTS 1270

  Fly  1340 GGDGRMSSPTLHFQMGK 1356
            .|.|..|........||
Mouse  1271 AGRGNSSEKVTIEPAGK 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/119 (24%)
		I-set	362..462	CDD:254352	28/120 (23%)
		Ig	466..559	CDD:299845	27/107 (25%)
		IG_like	584..657	CDD:214653	22/81 (27%)
		IGc2	586..645	CDD:197706	18/67 (27%)
		Ig	667..751	CDD:299845	20/101 (20%)
		IG_like	676..751	CDD:214653	19/92 (21%)
		IG_like	765..844	CDD:214653	28/89 (31%)
		Ig	773..844	CDD:299845	27/81 (33%)
		I-set	851..940	CDD:254352	15/106 (14%)
		Ig	866..944	CDD:299845	13/95 (14%)
		FN3	944..1043	CDD:238020	22/103 (21%)
		FN3	1053..1146	CDD:238020	25/111 (23%)
		fn3	1156..1244	CDD:278470	25/87 (29%)
		fn3	1259..1346	CDD:278470	19/86 (22%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706	4/16 (25%)
		Ig	125..218	CDD:353325	15/92 (16%)
		I-set	226..311	CDD:336764	17/86 (20%)
		Ig_3	317..389	CDD:339005	20/79 (25%)
		Ig	408..498	CDD:353325	28/113 (25%)
		IGc2	519..577	CDD:197706	18/63 (29%)
		Ig	615..681	CDD:319273	16/76 (21%)
		Ig_DSCAM	707..785	CDD:143211	27/80 (34%)
		Ig	803..891	CDD:353325	14/101 (14%)
		FN3	887..981	CDD:238020	23/106 (22%)
		FN3	988..1085	CDD:238020	25/114 (22%)
		FN3	1093..1186	CDD:238020	26/94 (28%)
		FN3	1191..1282	CDD:238020	21/94 (22%)
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100