DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Cntn5

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_446198.1	Gene:	Cntn5 / 114589	RGDID:	621302	Length:	1099	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	331/1079 - (30%)
Similarity:	501/1079 - (46%)	Gaps:	101/1079 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 YHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYRE-VYVDDR 409
            ||........|.:..||.||::|:|..|..:.:.  ..|.|:|...|.|:|:|.|.|. ..:|..
  Rat    83 YHSPDAFRQDESVDYGPVFVQEPDDIIFPTDSDE--KKVALNCEVRGNPSPTYRWLRNGTEIDLE 145

  Fly   410 LEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK- 473
            .:|         ||::..|..||..|.::.|.|.|.|:|.|.||.|.|..|.|.|.::..|:.:
  Rat   146 SDY---------RYSMIDGTFIINNPSESRDSGLYQCLATNTFGSILSREATLQFAYLGNFSGRT 201

  Fly   474 RSAETSEMNWGKSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRAN 537
            |||.:.....|..:.|.||.|.|::.|.|..:.||:||.||.|.|:|:: |.||.|.::|.|..:
  Rat   202 RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS 266

  Fly   538 YSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKV---FPEAPVA--GDEIRLECMAFG 597
            |.|.|:..|::.....|..||.:..:.     :.....||:   ||....|  |..:::||.|.|
  Rat   267 YICLVKNAVTNARVLSPPTPLTLRNDG-----VMGEYEPKIEVHFPTTVTAAKGTTVKMECFALG 326

  Fly   598 YPIPSYNWTRQGLPLQRNAYTINYGR------VLIIQNATTNDNGEYSCTITNPRKTLMKSIYIN 656
            .|:|:..|      ::.|.|..:..|      ||.|.|...:|.|.|.||..|.|........:.
  Rat   327 NPVPTITW------MKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQ 385

  Fly   657 IQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNA------ERLDPANINRDRYIIQD 715
            |...|.:...|.|...|..|.:.:.|:|...|...|.|.||.      .|:|.||
  Rat   386 IYTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTAN---------- 440

  Fly   716 NVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCD 780
            .||.|..:.: .|..||||.|:|:....::||:|::|:..|||:.:.::..:....:....|.|.
  Rat   441 GVLAIHSVNQ-SDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDREVLIECK 504

  Fly   781 PEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVL 845
            |:.:|:|...|:|..:.:.......|||.|:|.|...|:.|||.|.|...|..|:.|..|.|.|.
  Rat   505 PQGSPKPAISWRKGDKAVRGNKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASVSVK 569

  Fly   846 QEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVL----KNNHDGTGRIIVDWN 906
            :..| ||..|:|......:.|.|:|:|..|..||:.:.|...|:.:    :..|..:.|......
  Rat   570 EPTR-IELTPKRTELTVGESIVLNCKAMHDSSLDVTFYWTLKGQPIDFEKEGGHFESIRAQASSA 633

  Fly   907 RLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNG 971
            .|.:.|..:..||.|.|.|::..:.:|.:..:.:.|.||.||.|.|.:|:::.|.:.|...:.|.
  Rat   634 DLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNH 698

  Fly   972 RAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTP 1036
            ..|..||:..|:.::..|..|.|..:....|    .:.|..|:|.||..|||.|.|.|.:|.|.|
  Rat   699 SPISSYNLQARSPFSLGWQTVKTVPEVITGD----MESAMAVDLNPWVEYEFRVVATNPIGTGDP 759

  Fly  1037 SAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEW--- 1098
            |.||.:..|.|..|..||.||.||.|:..:|.|.|:|:..:.|:..|..|.|.::..|...|
  Rat   760 SIPSRMIRTNEAVPKTAPSNVSGGSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEK 824

  Fly  1099 --ASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPI 1161
              .|.:..|..:...:|.  ||    |.:||||...|:.|.||.|:|.||.|||..|..||....
  Rat   825 MVTSSDASKFIYRDESVP--PL----TPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVT 883

  Fly  1162 ALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDT 1226
            |.:.:.:...|.|:.:   :|:: |:..|..:.|||.|..|:.:....:|...::.::.||:.||
  Rat   884 ATSVSVSEIFVVWKHV---KESL-GRPQGFEIGYWKDTEPEDSAETVRTRGNESFVMLTGLEGDT 944

  Fly  1227 YYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEG 1291
            .|.:.|.|||.||.||.|......|.|..|.:||.::. :....|.|.:.|..|.|..:|..|.|
  Rat   945 LYHLTVRAYNGAGYGPPSREVSATTKRHPPSEPPGNLR-WEQQGSQVSLGWEPVRPLANESEVMG 1008

  Fly  1292 YKVRIWESDQNMITANNTIVPIGQKLESY----INNLTPGKSYNMRVLAYSNGGDGRMSS----P 1348
            |||...:...:.          ||.:|:.    :..|.....|.:.|.|||.||||..||    |
  Rat  1009 YKVFYRQEGHSK----------GQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVP 1063

  Fly  1349 TLHFQMGKTTRNGANTRHGHN--INTALILSTLLLISTF 1385
            :  :..||.| :..:|.|..:  .:..|:|:.:|..|::
  Rat  1064 S--YAGGKIT-SAQSTLHSLSKWSSVTLLLALMLPSSSW 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	34/99 (34%)
		I-set	362..462	CDD:254352	34/100 (34%)
		Ig	466..559	CDD:299845	33/94 (35%)
		IG_like	584..657	CDD:214653	23/80 (29%)
		IGc2	586..645	CDD:197706	20/64 (31%)
		Ig	667..751	CDD:299845	28/89 (31%)
		IG_like	676..751	CDD:214653	25/80 (31%)
		IG_like	765..844	CDD:214653	24/78 (31%)
		Ig	773..844	CDD:299845	24/70 (34%)
		I-set	851..940	CDD:254352	23/92 (25%)
		Ig	866..944	CDD:299845	20/81 (25%)
		FN3	944..1043	CDD:238020	35/98 (36%)
		FN3	1053..1146	CDD:238020	33/97 (34%)
		fn3	1156..1244	CDD:278470	27/87 (31%)
		fn3	1259..1346	CDD:278470	26/90 (29%)
Cntn5	NP_446198.1	Ig	98..191	CDD:299845	36/103 (35%)
		I-set	99..190	CDD:254352	34/101 (34%)
		Ig	193..287	CDD:299845	32/93 (34%)
		IG_like	205..278	CDD:214653	27/72 (38%)
		Ig	300..387	CDD:299845	27/92 (29%)
		I-set	300..386	CDD:254352	27/91 (30%)
		I-set	390..475	CDD:254352	29/95 (31%)
		Ig	392..475	CDD:299845	28/93 (30%)
		I-set	480..568	CDD:254352	27/87 (31%)
		Ig5_Contactin_like	496..568	CDD:143170	24/71 (34%)
		I-set	573..667	CDD:254352	24/94 (26%)
		Ig	587..671	CDD:299845	20/83 (24%)
		FN3	671..768	CDD:238020	35/100 (35%)
		FN3	776..868	CDD:238020	33/97 (34%)
		FN3	878..969	CDD:238020	28/94 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	958..983		8/25 (32%)
		FN3	976..1062	CDD:238020	28/96 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9086
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1297
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm45829
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740