DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cont and CHL1

DIOPT Version :9

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_006605.2 Gene:CHL1 / 10752 HGNCID:1939 Length:1224 Species:Homo sapiens


Alignment Length:1045 Identity:275/1045 - (26%)
Similarity:453/1045 - (43%) Gaps:122/1045 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 PYFVKQ-------PNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYRE---VYVDDRLEYQKID 416
            |..:||       |.|..|.:           .|.|.|.|.|:::|.::   .|..|    .:|.
Human    35 PTIIKQSKVQVAFPFDEYFQI-----------ECEAKGNPEPTFSWTKDGNPFYFTD----HRII 84

  Fly   417 PLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEM 481
            |...     ||...|..|...:..||.|.|.|.||.|...||........:.:|. |...:..|:
Human    85 PSNN-----SGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFP-KEKIDPLEV 143

  Fly   482 NWGKSIF--CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC--- 540
            ..|..|.  |:||:..|.:..||......: :|:|:||::|:.|.|||:.:|..| |.:|.|   
Human   144 EEGDPIVLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAA 207

  Fly   541 --TVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTF-----------------PKVFPEAPVAG 586
              .::|:|..       .|:::|.||    |..||..                 ||:......:|
Human   208 FPRLRTIVQK-------MPMKLTVNS----LKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESG 261

  Fly   587 DE----------IRLECMAFGYPIPSYNWTRQGLPLQRNAYT-INYGRVLIIQNATTNDNGEYSC 640
            .|          :.|||.|.|.|.|..:|.:.|..|.:...| .|||:.|.|:|.:..|.|.|.|
Human   262 SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRC 326

  Fly   641 TITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPAN 705
            |.:|...|.....::.::..|::|...:..:....|:...:|||...|.....|..|...:|...
Human   327 TASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHP 391

  Fly   706 INRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAV 770
            ...|  ::....::...|:.: ..|:|||.|.|...|..::|.:.|:.::|..:..  :.|.||.
Human   392 FAGD--VVFPREISFTNLQPN-HTAVYQCEASNVHGTILANANIDVVDVRPLIQTK--DGENYAT 451

  Fly   771 YNGNTTIV-CDPEAAPRPKFQWKKDGQVIGSGGHR-RILPSGTLTISPTSRDDEGIYTCIASNQA 833
            ..|.:..: |:..|:|.....|:|..:|....|.| .|..:|||.|:.|:.:|.|.|:|...|..
Human   452 VVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAI 516

  Fly   834 GTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELL--DIAYVWKHNGEVLKNNHD 896
            |.....|.:.:....:...:|....:.|.| ::.||||:..|..|  .:...|..:||..:.|..
Human   517 GKTAVTANLDIRNATKLRVSPKNPRIPKLH-MLELHCESKCDSHLKHSLKLSWSKDGEAFEINGT 580

  Fly   897 GTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAI 961
            ..||||:|...||:.|.::.|.|.|.|...:|::..:..|.|::...|..|..:.:.:.......
Human   581 EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVR 645

  Fly   962 IEWVDGS-HNGRAIRY-YNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFS 1024
            :.|..|: ||.....| ....|.......|         .|:.|...::...::.|.|:..|:|.
Human   646 LTWEAGADHNSNISEYIVEFEGNKEEPGRW---------EELTRVQGKKTTVILPLAPFVRYQFR 701

  Fly  1025 VTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVF 1089
            |.|||::|...||.||..:.|....|...|:|:.....:..::.|.|:||...||:..|:.|:|.
Human   702 VIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVT 766

  Fly  1090 WKLKGA-IEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMP 1153
            ||.:|| :||..:.:...      .:.:.....|..|:|||||||.:|.||:.:...::|.||.|
Human   767 WKPQGAPVEWEEETVTNH------TLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYP 825

  Fly  1154 QVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKT-------THQEEDSVYYLSR 1211
            ..||........|||...|||..:  .::.:.|:|.|:::.:|||       ||.:|.::...| 
Human   826 DTAPVIHGVDVINSTLVKVTWSTV--PKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFS- 887

  Fly  1212 TTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVV 1276
            ..||..::..|...:.:.:.|:|||:.|.|||||.:..:|....|:: |:.:.|..::..|..:.
Human   888 GQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFLKVIKVDKDTATLS 951

  Fly  1277 WRYVSPSQDEEPVEGY--KVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSN 1339
            |..  |.:....:.||  :.:|......:...|:..:....|...:::||.....|...:.|.::
Human   952 WGL--PKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTS 1014

  Fly  1340 GGDGR 1344
            .|.|:
Human  1015 QGCGK 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..460 CDD:299845 30/107 (28%)
I-set 362..462 CDD:254352 30/109 (28%)
Ig 466..559 CDD:299845 28/100 (28%)
IG_like 584..657 CDD:214653 26/83 (31%)
IGc2 586..645 CDD:197706 24/69 (35%)
Ig 667..751 CDD:299845 18/83 (22%)
IG_like 676..751 CDD:214653 18/74 (24%)
IG_like 765..844 CDD:214653 25/80 (31%)
Ig 773..844 CDD:299845 22/72 (31%)
I-set 851..940 CDD:254352 28/90 (31%)
Ig 866..944 CDD:299845 25/79 (32%)
FN3 944..1043 CDD:238020 24/100 (24%)
FN3 1053..1146 CDD:238020 29/93 (31%)
fn3 1156..1244 CDD:278470 28/94 (30%)
fn3 1259..1346 CDD:278470 16/88 (18%)
CHL1NP_006605.2 Ig 55..126 CDD:299845 24/90 (27%)
Ig2_L1-CAM_like 129..223 CDD:143253 28/102 (27%)
IG_like 140..224 CDD:214653 26/91 (29%)
IG_like 264..343 CDD:214653 24/78 (31%)
Ig3_L1-CAM_like 274..344 CDD:143208 24/69 (35%)
IG_like 353..434 CDD:214653 18/83 (22%)
Ig4_L1-NrCAM_like 361..435 CDD:143179 18/76 (24%)
IG_like 447..525 CDD:214653 25/77 (32%)
Ig 457..525 CDD:299845 21/67 (31%)
IG_like 548..624 CDD:214653 25/75 (33%)
Ig 548..616 CDD:143165 23/67 (34%)
DGEA 571..574 1/2 (50%)
FN3 628..717 CDD:238020 22/97 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..732 7/22 (32%)
fn3 731..811 CDD:278470 27/85 (32%)
FN3 834..927 CDD:238020 29/95 (31%)
FN3 932..1027 CDD:238020 17/91 (19%)
Bravo_FIGEY 1120..1205 CDD:290593
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1179
FIG[AQ]Y 1197..1201
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1205..1224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I11028
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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