DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cont and CHL1

DIOPT Version :10

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_006605.2 Gene:CHL1 / 10752 HGNCID:1939 Length:1224 Species:Homo sapiens


Alignment Length:1045 Identity:275/1045 - (26%)
Similarity:453/1045 - (43%) Gaps:122/1045 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 PYFVKQ-------PNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYRE---VYVDDRLEYQKID 416
            |..:||       |.|..|.:           .|.|.|.|.|:::|.::   .|..|    .:|.
Human    35 PTIIKQSKVQVAFPFDEYFQI-----------ECEAKGNPEPTFSWTKDGNPFYFTD----HRII 84

  Fly   417 PLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEM 481
            |...     ||...|..|...:..||.|.|.|.||.|...||........:.:|. |...:..|:
Human    85 PSNN-----SGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFP-KEKIDPLEV 143

  Fly   482 NWGKSIF--CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC--- 540
            ..|..|.  |:||:..|.:..||......: :|:|:||::|:.|.|||:.:|..| |.:|.|   
Human   144 EEGDPIVLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAA 207

  Fly   541 --TVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTF-----------------PKVFPEAPVAG 586
              .::|:|..       .|:::|.||    |..||..                 ||:......:|
Human   208 FPRLRTIVQK-------MPMKLTVNS----LKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESG 261

  Fly   587 DE----------IRLECMAFGYPIPSYNWTRQGLPLQRNAYT-INYGRVLIIQNATTNDNGEYSC 640
            .|          :.|||.|.|.|.|..:|.:.|..|.:...| .|||:.|.|:|.:..|.|.|.|
Human   262 SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRC 326

  Fly   641 TITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPAN 705
            |.:|...|.....::.::..|::|...:..:....|:...:|||...|.....|..|...:|...
Human   327 TASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHP 391

  Fly   706 INRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAV 770
            ...|  ::....::...|:.: ..|:|||.|.|...|..::|.:.|:.::|..:..  :.|.||.
Human   392 FAGD--VVFPREISFTNLQPN-HTAVYQCEASNVHGTILANANIDVVDVRPLIQTK--DGENYAT 451

  Fly   771 YNGNTTIV-CDPEAAPRPKFQWKKDGQVIGSGGHR-RILPSGTLTISPTSRDDEGIYTCIASNQA 833
            ..|.:..: |:..|:|.....|:|..:|....|.| .|..:|||.|:.|:.:|.|.|:|...|..
Human   452 VVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAI 516

  Fly   834 GTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELL--DIAYVWKHNGEVLKNNHD 896
            |.....|.:.:....:...:|....:.|.| ::.||||:..|..|  .:...|..:||..:.|..
Human   517 GKTAVTANLDIRNATKLRVSPKNPRIPKLH-MLELHCESKCDSHLKHSLKLSWSKDGEAFEINGT 580

  Fly   897 GTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAI 961
            ..||||:|...||:.|.::.|.|.|.|...:|::..:..|.|::...|..|..:.:.:.......
Human   581 EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVR 645

  Fly   962 IEWVDGS-HNGRAIRY-YNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFS 1024
            :.|..|: ||.....| ....|.......|         .|:.|...::...::.|.|:..|:|.
Human   646 LTWEAGADHNSNISEYIVEFEGNKEEPGRW---------EELTRVQGKKTTVILPLAPFVRYQFR 701

  Fly  1025 VTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVF 1089
            |.|||::|...||.||..:.|....|...|:|:.....:..::.|.|:||...||:..|:.|:|.
Human   702 VIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVT 766

  Fly  1090 WKLKGA-IEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMP 1153
            ||.:|| :||..:.:...      .:.:.....|..|:|||||||.:|.||:.:...::|.||.|
Human   767 WKPQGAPVEWEEETVTNH------TLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYP 825

  Fly  1154 QVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKT-------THQEEDSVYYLSR 1211
            ..||........|||...|||..:  .::.:.|:|.|:::.:|||       ||.:|.::...| 
Human   826 DTAPVIHGVDVINSTLVKVTWSTV--PKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFS- 887

  Fly  1212 TTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVV 1276
            ..||..::..|...:.:.:.|:|||:.|.|||||.:..:|....|:: |:.:.|..::..|..:.
Human   888 GQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFLKVIKVDKDTATLS 951

  Fly  1277 WRYVSPSQDEEPVEGY--KVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSN 1339
            |..  |.:....:.||  :.:|......:...|:..:....|...:::||.....|...:.|.::
Human   952 WGL--PKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTS 1014

  Fly  1340 GGDGR 1344
            .|.|:
Human  1015 QGCGK 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..466 CDD:472250 30/113 (27%)
Ig strand B 384..388 CDD:409356 0/3 (0%)
Ig strand C 397..409 CDD:409356 2/14 (14%)
Ig strand E 428..432 CDD:409356 0/3 (0%)
Ig strand F 443..448 CDD:409356 2/4 (50%)
Ig strand G 457..460 CDD:409356 2/2 (100%)
Ig 474..559 CDD:472250 26/92 (28%)
Ig strand B 485..489 CDD:409392 1/5 (20%)
Ig strand C 499..503 CDD:409392 1/3 (33%)
Ig strand E 523..527 CDD:409392 2/3 (67%)
Ig strand F 537..542 CDD:409392 2/9 (22%)
Ig strand G 553..556 CDD:409392 0/2 (0%)
Ig_3 584..644 CDD:464046 24/70 (34%)
Ig_3 660..738 CDD:464046 17/77 (22%)
Ig 756..844 CDD:472250 26/89 (29%)
Ig strand B 775..779 CDD:409358 0/4 (0%)
Ig strand C 788..792 CDD:409358 0/3 (0%)
Ig strand E 810..814 CDD:409358 3/3 (100%)
Ig strand F 824..829 CDD:409358 2/4 (50%)
Ig strand G 837..840 CDD:409358 0/2 (0%)
Ig <868..944 CDD:472250 25/77 (32%)
Ig strand C 881..885 CDD:409359 0/3 (0%)
Ig strand E 906..910 CDD:409359 1/3 (33%)
Ig strand F 920..925 CDD:409359 2/4 (50%)
Ig strand G 933..936 CDD:409359 0/2 (0%)
FN3 944..1043 CDD:238020 24/100 (24%)
FN3 1053..1146 CDD:238020 29/93 (31%)
fn3 1156..1244 CDD:394996 28/94 (30%)
fn3 1259..1346 CDD:394996 16/88 (18%)
CHL1NP_006605.2 Ig 35..126 CDD:472250 30/110 (27%)
Ig strand B 53..57 CDD:409396 1/14 (7%)
Ig strand C 66..70 CDD:409396 0/3 (0%)
Ig strand E 90..94 CDD:409396 1/3 (33%)
Ig strand F 106..111 CDD:409396 2/4 (50%)
Ig strand G 120..123 CDD:409396 2/2 (100%)
IgI_2_L1-CAM_like 135..225 CDD:409432 28/97 (29%)
Ig strand A 135..138 CDD:409432 1/2 (50%)
Ig strand A' 140..144 CDD:409432 1/3 (33%)
Ig strand B 147..155 CDD:409432 2/7 (29%)
Ig strand C 162..168 CDD:409432 2/5 (40%)
Ig strand C' 171..174 CDD:409432 0/3 (0%)
Ig strand D 180..184 CDD:409432 1/3 (33%)
Ig strand E 186..190 CDD:409432 2/3 (67%)
Ig strand F 201..209 CDD:409432 2/7 (29%)
Ig strand G 212..225 CDD:409432 4/19 (21%)
Ig3_L1-CAM_like 262..344 CDD:409394 25/81 (31%)
Ig strand B 274..278 CDD:409394 1/3 (33%)
Ig strand C 287..291 CDD:409394 0/3 (0%)
Ig strand E 309..313 CDD:409394 1/3 (33%)
Ig strand F 323..328 CDD:409394 2/4 (50%)
Ig strand G 336..339 CDD:409394 0/2 (0%)
Ig4_L1-NrCAM_like 348..435 CDD:409367 19/89 (21%)
Ig strand B 364..368 CDD:409367 0/3 (0%)
Ig strand C 377..381 CDD:409367 0/3 (0%)
Ig strand E 400..404 CDD:409367 0/3 (0%)
Ig strand F 414..419 CDD:409367 3/4 (75%)
Ig strand G 427..430 CDD:409367 0/2 (0%)
Ig 448..525 CDD:472250 24/76 (32%)
Ig strand B 457..461 CDD:409390 0/3 (0%)
Ig strand C 470..474 CDD:409390 0/3 (0%)
Ig strand E 493..497 CDD:409390 3/3 (100%)
Ig strand F 507..512 CDD:409390 2/4 (50%)
Ig strand G 520..523 CDD:409390 0/2 (0%)
Ig 548..617 CDD:409353 23/68 (34%)
Ig strand B 548..552 CDD:409353 1/3 (33%)
Ig strand C 565..569 CDD:409353 0/3 (0%)
DGEA 571..574 1/2 (50%)
Ig strand E 590..594 CDD:409353 1/3 (33%)
Ig strand F 604..609 CDD:409353 2/4 (50%)
FN3 <616..>868 CDD:442628 73/268 (27%)
FN3 628..717 CDD:238020 22/97 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..732 7/22 (32%)
FN3 834..927 CDD:238020 29/95 (31%)
FN3 932..1027 CDD:238020 17/91 (19%)
Bravo_FIGEY 1120..1205 CDD:464016
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1179
FIG[AQ]Y 1197..1201
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1205..1224
Blue background indicates that the domain is not in the aligned region.

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