DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn1

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_002932857.1	Gene:	cntn1 / 100487602	XenbaseID:	XB-GENE-491714	Length:	1005	Species:	Xenopus tropicalis

Alignment Length:	1036	Identity:	326/1036 - (31%)
Similarity:	493/1036 - (47%)	Gaps:	135/1036 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425
            ||.|.:||.||.|.  :..:...|:::|.|...|.|.|.|.|..:        :|| |..:.|::
Frog    24 GPVFEEQPIDTIFP--EESMEGKVSVNCRARANPPPVYKWRRNNW--------EID-LLNEHYSL 77

  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETS-EMNWGKSIFC 489
            .||||:|..|.:..|.|.|.|:..|.:|::.|..|:||||::..|..:...|.. :...|..:.|
Frog    78 VGGNLVINNPDKYKDSGKYVCIVSNMYGKVWSREANLNFGYLDPFPTEERYEVKVKEGTGAVLIC 142

  Fly   490 DPPQHYP-DVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVDRANYSCTVQT-------- 544
            |||.|:| |:.|.|..:.||.|:..|.|.||:: :|.||.:.:|..||.||||.|.:
Frog   143 DPPPHFPDDLNYRWLLNEFPVFISPDNRRFVTQANGNLYIAKVEQSDRGNYSCFVSSPSVTKSVF 207

  Fly   545 --LVS-----DTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDE-IRLECMAFGYPIP 601
              .:|     ||...    |.|.||..|.:           |.:.....|: :.|||.|.|.|||
Frog   208 SKFISLLPQTDTSEK----PKRYTPVINVK-----------FKDTRALKDQNVTLECFALGNPIP 257

  Fly   602 SYNWTRQGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIP 666
            ...|.:....:..:|.....|.||.|.|....|.|.|.|...|.:.......|:.::..|::...
Frog   258 VITWRKTNEAMPASAEISMSGAVLKIFNIQPEDEGTYECEAKNIKGMDTHKAYVYVEGVPEWVEH 322

  Fly   667 LKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAM 731
            :.|..:|..||:.:.|.|...|..:..|.||.......::.:       ..||:      :|..|
Frog   323 INDTERDIGSDLHWACVAKGKPQPSIRWLKNGASYGKGDLIK-------RGLTL------EDAGM 374

  Fly   732 YQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQ 796
            |||.|:|.....:::|:|::|::.|:|:..|:..:|.|...|...|.|.|:|||:.||.|.|..:
Frog   375 YQCIAENMHGIIYANAELKILALAPTFEFTPMRKKVLAAKGGRVIIECKPKAAPKAKFSWSKGTE 439

  Fly   797 VIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSK 861
            ::.:.....|...|:|.|...::.|||.|||.|.|..|...|...:.|....:....|....|:.
Frog   440 LLINSSRVSIWDDGSLEILNITKLDEGSYTCFAENDRGKANSTGVLSVTAATKITLAPSNADVTV 504

  Fly   862 EHDLIFLHCEAAFDELLDIAYVWKHNGEVLK-NNHDG-TGRIIVD--WNRLTVHNTSMRDAGDYE 922
            ..:.. :.|.|:.|..||:.::|..||..:: :..|| ..|.|.:  .:.|.:.|..::.||.|.
Frog   505 GENAT-MQCHASHDPTLDLTFIWTLNGFPIEFDKEDGHYERAIRNDVGSELVIKNAQLKHAGRYT 568

  Fly   923 CVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNR 987
            |..::.|:..|:...:.:.|.||.||||:|.:|..|...:.|..|:.|.:.|..|||..:...:.
Frog   569 CTAQTIVDNSSASADLVVRGPPGPPGGVRVEEIRDTSVKLTWSSGTDNHQPISKYNIQAKNILSE 633

  Fly   988 TWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYI 1052
            .|.:|.|.....|    .:.:.|..::|.||..|||.|||.|.||:|.||.|||...|....|.:
Frog   634 DWKDVKTENPNIE----GNMEMARAIDLIPWMDYEFRVTATNTLGVGEPSLPSPKIRTEGAAPIV 694

  Fly  1053 APRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIP 1117
            ||..||||||...:||:||.||..:..:..|..|.|.:||....||..           .:|..|
Frog   695 APAEVGGGGGSNRELTVTWQPLSREYHYGDGFGYVVAFKLFNYREWRK-----------VIVTNP 748

  Fly  1118 LNNYY----------TEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYN---STC 1169
            .:.:|          |:::|||:|.|.||:||.|...||:||||:|..|   |.|:.||   |:.
Frog   749 ESGHYVHKDDTITPATQFQVKVKAFNKVGEGPYSSTVVIYSAEDVPIEA---PTAIVYNILSSSE 810

  Fly  1170 FNVTWQPI-DMSRENIRGKLIGHRLKYWKTTHQEEDS----VYYLSRTTRNWALIVGLQPDTYYF 1229
            .:|.|.|: :.|.|       |::::||:|..:|..:    |.....|||    :.||.|||:|.
Frog   811 VSVAWHPVYEKSIE-------GYQVRYWRTQDKEAAAHRVQVKASDITTR----LEGLLPDTHYN 864

  Fly  1230 VKVMAYNAAGEGPESERFEERTYRKAP--QKP--PSSVHVYGINPSTVRVVWRYVSPSQDEEPVE 1290
            ::|.|:|:||:||.|......| :|||  |||  .|:|. ||   |...:.|.:|.|..:|..|.
Frog   865 LEVRAFNSAGDGPPSRVITFLT-KKAPPSQKPRITSAVR-YG---SQYIITWEHVVPLSNESAVN 924

  Fly  1291 GYKVRIWESDQN----MITANNTI-VPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMS 1346
            ||||...:..|.    ..|..::: :|:.::.|           |.:.|.|:|.||||.::
Frog   925 GYKVLYRQDGQRDGKLYSTGKHSVELPVPEEGE-----------YVVEVRAHSEGGDGAVA 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	33/98 (34%)
		I-set	362..462	CDD:254352	33/99 (33%)
		Ig	466..559	CDD:299845	34/110 (31%)
		IG_like	584..657	CDD:214653	22/73 (30%)
		IGc2	586..645	CDD:197706	20/59 (34%)
		Ig	667..751	CDD:299845	21/83 (25%)
		IG_like	676..751	CDD:214653	19/74 (26%)
		IG_like	765..844	CDD:214653	27/78 (35%)
		Ig	773..844	CDD:299845	25/70 (36%)
		I-set	851..940	CDD:254352	22/92 (24%)
		Ig	866..944	CDD:299845	21/81 (26%)
		FN3	944..1043	CDD:238020	39/98 (40%)
		FN3	1053..1146	CDD:238020	35/102 (34%)
		fn3	1156..1244	CDD:278470	33/95 (35%)
		fn3	1259..1346	CDD:278470	27/93 (29%)
cntn1	XP_002932857.1	Ig	24..118	CDD:416386	37/104 (36%)
		Ig strand A	26..30	CDD:409353	1/3 (33%)
		Ig strand A'	33..38	CDD:409353	3/6 (50%)
		Ig strand B	44..52	CDD:409353	2/7 (29%)
		Ig strand C	57..63	CDD:409353	3/5 (60%)
		Ig strand C'	65..68	CDD:409353	0/10 (0%)
		Ig strand D	74..78	CDD:409353	1/3 (33%)
		Ig strand E	80..86	CDD:409353	4/5 (80%)
		Ig strand F	93..102	CDD:409353	3/8 (38%)
		Ig strand G	105..118	CDD:409353	6/12 (50%)
		Ig2_Contactin-2-like	126..214	CDD:409392	30/87 (34%)
		Ig strand B	138..142	CDD:409392	0/3 (0%)
		Ig strand C	153..157	CDD:409392	1/3 (33%)
		Ig strand E	178..182	CDD:409392	2/3 (67%)
		Ig strand F	192..197	CDD:409392	4/4 (100%)
		Ig strand G	208..211	CDD:409392	0/2 (0%)
		Ig	227..314	CDD:416386	26/97 (27%)
		Ig strand A	227..232	CDD:409353	2/4 (50%)
		Ig strand A'	235..240	CDD:409353	0/4 (0%)
		Ig strand B	243..252	CDD:409353	3/8 (38%)
		Ig strand C	258..262	CDD:409353	0/3 (0%)
		Ig strand C'	265..267	CDD:409353	0/1 (0%)
		Ig strand D	275..278	CDD:409353	0/2 (0%)
		Ig strand E	279..284	CDD:409353	2/4 (50%)
		Ig strand F	292..300	CDD:409353	3/7 (43%)
		Ig strand G	303..314	CDD:409353	1/10 (10%)
		Ig	318..394	CDD:416386	21/88 (24%)
		Ig strand A	318..321	CDD:409353	0/2 (0%)
		Ig strand A'	325..329	CDD:409353	1/3 (33%)
		Ig strand B	333..341	CDD:409353	2/7 (29%)
		Ig strand C	347..352	CDD:409353	1/4 (25%)
		Ig strand E	360..365	CDD:409353	0/11 (0%)
		Ig strand F	374..381	CDD:409353	5/6 (83%)
		Ig strand G	385..394	CDD:409353	2/8 (25%)
		Ig	399..487	CDD:416386	30/87 (34%)
		Ig strand A	399..404	CDD:409353	2/4 (50%)
		Ig strand A'	407..412	CDD:409353	1/4 (25%)
		Ig strand B	416..423	CDD:409353	2/6 (33%)
		Ig strand C	431..435	CDD:409353	2/3 (67%)
		Ig strand D	449..452	CDD:409353	1/2 (50%)
		Ig strand E	453..458	CDD:409353	2/4 (50%)
		Ig strand F	466..474	CDD:409353	5/7 (71%)
		Ig strand G	480..487	CDD:409353	1/6 (17%)
		Ig6_Contactin	490..584	CDD:409359	22/94 (23%)
		Ig strand B	508..512	CDD:409359	0/4 (0%)
		Ig strand C	523..527	CDD:409359	0/3 (0%)
		Ig strand E	552..556	CDD:409359	1/3 (33%)
		Ig strand F	566..571	CDD:409359	2/4 (50%)
		Ig strand G	579..582	CDD:409359	1/2 (50%)
		FN3	596..687	CDD:238020	34/94 (36%)
		FN3	695..788	CDD:238020	36/103 (35%)
		FN3	796..886	CDD:238020	34/103 (33%)
		FN3	909..972	CDD:238020	20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9051
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm48919
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060