DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn2

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_031752703.1	Gene:	cntn2 / 100487049	XenbaseID:	XB-GENE-6070188	Length:	1033	Species:	Xenopus tropicalis

Alignment Length:	1070	Identity:	309/1070 - (28%)
Similarity:	476/1070 - (44%)	Gaps:	113/1070 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425
            ||.|.:||.:|.|.  ...:...|||.|.|...|:.:|.|        :|...:::..|...|.:
Frog    31 GPVFEEQPENTLFP--DGSIEEQVTLPCRARASPSATYRW--------QLNGTELNLTADPSYRL 85

  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKR--SAETSEMNWGKSIF 488
            .||||.|..|.|:...|.|.|:|.|..|.:.|..|.|.||::.||..::  :.:.:| .||..:.
Frog    86 VGGNLAISGPTQSKHAGTYQCIASNPKGTVLSSEASLRFGYLQEFPAEQRDTVKVTE-GWGVMLA 149

  Fly   489 CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVDRANYSCTVQTLVSDTGRN 552
            |:||:|||.:.|.|..:.||.|:..|.|.|||: .|.||.:.....|...|||...:.:|.|.::
Frog   150 CNPPKHYPGLSYRWLLNEFPTFLNTDNRRFVSQVTGNLYVAQTVKEDEGAYSCLTTSHISFTTKS 214

  Fly   553 --GPFFPLRVTPNSNYQALIFANTFPKVFPEAPVA--GDEIRLECMAFGYPIPSYNWTRQGLPLQ 613
              ..|..|.|  ||..:...:|.:....||....|  |..:.|||.|||.|:|...|.:....|.
Frog   215 VYSSFTQLNV--NSEVKPRTYAPSIKVRFPGETYALYGQAVFLECFAFGNPVPHIRWRKVDGTLP 277

  Fly   614 RNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDV 678
            .....|:  .||...:.|..::|.|.|...|...:......:.:|.:|::...:.|......||:
Frog   278 PRLLVID--PVLHFPSITFEEDGTYECEAVNSEGSTTHQGRVIVQAQPEWLHVITDTEAKIGSDL 340

  Fly   679 TFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNV-LT---IKFLEKD-KDDAMYQCGAQN 738
            .:.|.|...|.....|.::.:.|          :.|.|: :|   |||.... .|..||||.|:|
Frog   341 LWSCAASGKPRPTIRWLRDGKPL----------MTQVNIEITNGQIKFTSLSLHDSGMYQCVAEN 395

  Fly   739 QLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGH 803
            :..|.:::|:|.|.::.|.|:..|::..:.|...|...|.|:|.|||.|...|.|..:::.:...
Frog   396 KHGTIYTTAELTVQALAPDFRLSPVKRLIPAARGGEVIIQCNPRAAPTPLILWSKGTELLFNSSR 460

  Fly   804 RRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFL 868
            ..:..:|||.:...||.|||.|||.|.|..|...| ..|:.::|...|...|......:.|.|.|
Frog   461 VTVTANGTLILRNISRSDEGKYTCFAENIMGKSNS-TGVLSVREATKITLAPSGSDINQGDSITL 524

  Fly   869 HCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNR----------------LTVHNTSMRD 917
            .|.|:.|..:|:.:.|..||            |.:|:.:                |.:.|..:|.
Frog   525 QCHASHDPSMDLTFTWTLNG------------IPIDFEKEAQNYRRTSMDEAVGDLHIINAQLRH 577

  Fly   918 AGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGR 982
            ||.|.|:.::.|:..|:..|:.|.|.||.||||.|..:.:|...:.|..|..|...|..|.:..|
Frog   578 AGKYTCMAQTVVDRTSAMASLLIRGPPGPPGGVVVKYVGETMVQLSWSRGFDNHSPISRYVVQVR 642

  Fly   983 TNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYE 1047
            ......|.:..|.....|    .:.:.|.||.|..|:.|.|.:.|.|.||.|.|||||.:..|.|
Frog   643 EPLTEIWRSARTDPPTVE----GNAESALVVGLNQWTDYLFRIVASNILGDGDPSAPSALIRTRE 703

  Fly  1048 DKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEI---KKQDHM 1109
            ..|.:||..||||||...:|||.|.|:..|.|:.....|.:.:|.|....|.:..:   :.|.::
Frog   704 AAPNVAPSEVGGGGGAPNELTINWTPIGRQYQNGDDFGYIIAFKRKNENTWLTVRVPGGQSQQYV 768

  Fly  1110 ----GVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCF 1170
                .:|.        ||.::||:|..|..|:||.|....::|||:.|::.|.:..|.|.:|:..
Frog   769 YRNESIAA--------YTPFDVKIQGYNKKGEGPFSRDTTVYSAEEEPRMFPSEVKATAISSSDI 825

  Fly  1171 NVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAY 1235
            .|.|.|:    :.::|.|:|:.::||||:.:|..:....|......|.:..|:|||.|:|.|..|
Frog   826 EVAWNPV----QTLKGVLLGYEIRYWKTSDKEAAADRVRSAGMATTAHVTSLKPDTTYYVTVRVY 886

  Fly  1236 NAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESD 1300
            |.||.||.|......|.:....|.|.::. :.::..::.:.|..|...|:|..|.|||:
Frog   887 NQAGTGPSSPATNVTTSKAPSSKLPENIK-WTLSRKSLSIKWNPVVALQNESSVTGYKI------ 944

  Fly  1301 QNMITANNTIVPIGQKLESYINNLT-------PG-KSYNMRVLAYSNGGDGRMSSPTLHFQMGKT 1357
              :...::...||     .|:.:.|       .| .:..:::.|...||||..:.  :|......
Frog   945 --LYRMSHHSTPI-----LYVTSKTHIELPFPEGFSTVTIQLRATGKGGDGEPAE--VHIPTDSG 1000

  Fly  1358 TRNGANTRHGHNINTALILSTLLLISTFLY 1387
            |...........|...|...|..|:....|
Frog  1001 TSMMVENSASRPITQTLAAKTTTLLFLIRY 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	32/98 (33%)
		I-set	362..462	CDD:254352	32/99 (32%)
		Ig	466..559	CDD:299845	31/97 (32%)
		IG_like	584..657	CDD:214653	20/74 (27%)
		IGc2	586..645	CDD:197706	18/58 (31%)
		Ig	667..751	CDD:299845	24/88 (27%)
		IG_like	676..751	CDD:214653	23/79 (29%)
		IG_like	765..844	CDD:214653	27/78 (35%)
		Ig	773..844	CDD:299845	26/70 (37%)
		I-set	851..940	CDD:254352	24/104 (23%)
		Ig	866..944	CDD:299845	23/93 (25%)
		FN3	944..1043	CDD:238020	34/98 (35%)
		FN3	1053..1146	CDD:238020	31/99 (31%)
		fn3	1156..1244	CDD:278470	30/87 (34%)
		fn3	1259..1346	CDD:278470	19/94 (20%)
cntn2	XP_031752703.1	Ig	324..408	CDD:416386	24/93 (26%)
		Ig strand A	324..327	CDD:409353	0/2 (0%)
		Ig strand A'	331..335	CDD:409353	1/3 (33%)
		Ig strand B	339..347	CDD:409353	2/7 (29%)
		Ig strand C	353..358	CDD:409353	1/4 (25%)
		Ig strand C'	360..363	CDD:409353	0/2 (0%)
		Ig strand D	368..372	CDD:409353	1/3 (33%)
		Ig strand E	374..379	CDD:409353	2/4 (50%)
		Ig strand F	388..395	CDD:409353	5/6 (83%)
		Ig strand G	399..408	CDD:409353	3/8 (38%)
		Ig5_Contactin	413..501	CDD:409358	30/88 (34%)
		Ig strand B	432..436	CDD:409358	1/3 (33%)
		Ig strand C	445..449	CDD:409358	0/3 (0%)
		Ig strand E	467..471	CDD:409358	3/3 (100%)
		Ig strand F	481..486	CDD:409358	3/4 (75%)
		Ig strand G	494..497	CDD:409358	1/3 (33%)
		Ig	503..601	CDD:416386	25/109 (23%)
		Ig strand A	503..509	CDD:409353	2/5 (40%)
		Ig strand A'	512..517	CDD:409353	0/4 (0%)
		Ig strand B	520..528	CDD:409353	4/7 (57%)
		Ig strand C	537..541	CDD:409353	0/3 (0%)
		Ig strand D	562..565	CDD:409353	0/2 (0%)
		Ig strand E	566..570	CDD:409353	1/3 (33%)
		Ig strand F	579..586	CDD:409353	3/6 (50%)
		Ig strand G	593..597	CDD:409353	1/3 (33%)
		FN3	615..696	CDD:238020	25/84 (30%)
		FN3	709..802	CDD:238020	31/100 (31%)
		FN3	812..902	CDD:238020	31/93 (33%)
		FN3	911..997	CDD:238020	20/101 (20%)
		Ig	30..126	CDD:416386	35/104 (34%)
		Ig strand A	33..37	CDD:409353	1/3 (33%)
		Ig strand A'	40..45	CDD:409353	2/6 (33%)
		Ig strand B	51..59	CDD:409353	4/7 (57%)
		Ig strand C	64..70	CDD:409353	2/13 (15%)
		Ig strand C'	72..75	CDD:409353	0/2 (0%)
		Ig strand D	82..86	CDD:409353	1/3 (33%)
		Ig strand E	88..94	CDD:409353	4/5 (80%)
		Ig strand F	101..110	CDD:409353	4/8 (50%)
		Ig strand G	113..126	CDD:409353	5/12 (42%)
		Ig	134..223	CDD:416386	29/89 (33%)
		Ig strand A	136..141	CDD:409353	0/4 (0%)
		Ig strand B	145..151	CDD:409353	1/5 (20%)
		Ig strand C	159..165	CDD:409353	2/5 (40%)
		Ig strand C'	170..172	CDD:409353	0/1 (0%)
		Ig strand D	177..182	CDD:409353	3/4 (75%)
		Ig strand E	185..189	CDD:409353	2/3 (67%)
		Ig strand F	199..207	CDD:409353	3/7 (43%)
		Ig strand G	209..223	CDD:409353	3/13 (23%)
		Ig	235..320	CDD:416386	22/86 (26%)
		Ig strand A	235..240	CDD:409353	0/4 (0%)
		Ig strand A'	243..248	CDD:409353	0/4 (0%)
		Ig strand B	251..260	CDD:409353	3/8 (38%)
		Ig strand C	266..270	CDD:409353	0/3 (0%)
		Ig strand C'	273..275	CDD:409353	0/1 (0%)
		Ig strand D	281..284	CDD:409353	0/2 (0%)
		Ig strand E	285..290	CDD:409353	2/4 (50%)
		Ig strand F	298..306	CDD:409353	3/7 (43%)
		Ig strand G	309..320	CDD:409353	0/10 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9051
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm48919
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060