DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn4

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001135636.1	Gene:	cntn4 / 100216195	XenbaseID:	XB-GENE-492899	Length:	1028	Species:	Xenopus tropicalis

Alignment Length:	1052	Identity:	321/1052 - (30%)
Similarity:	504/1052 - (47%)	Gaps:	78/1052 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 RGPYFVKQPNDTTFDV-NKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRY 423
            :||.|.::|.:..|.: :::|.:.   |.|...|:|.|...|        |:....:|.....||
Frog    23 QGPVFTQEPPNINFPLDSEDRTLR---LVCEVQGHPKPVVRW--------RVNGTLMDEAQDYRY 76

  Fly   424 TISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWGKSI 487
            .:...:|||..|.:..|.|.:.|.|.|..|.|.|..|::.|.::..|..: ||..:.....|..:
Frog    77 RVLDRSLIIASPDRNRDVGTFQCEATNSLGTILSREAYVQFSYLDSFQTRTRSTVSVREGQGMVL 141

  Fly   488 FCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVDRANYSCTVQTLVSDTGR 551
            .|.||.|..::.|.|..:.:|.||::|.|.|||: .|.||.:.:|..|..||:|.|...|::|..
Frog   142 LCGPPAHSGELVYAWIFNEYPPFVQQDNRRFVSQVTGNLYIAKVEPSDAGNYTCVVTNTVTNTRE 206

  Fly   552 NGPFFPLRVTPNSNYQALIFANTFPKV---FPEA-PVA-GDEIRLECMAFGYPIPSYNWTR-QGL 610
            .||..||.:..:.     :.....||:   |||: |.| |..::|||.|.|.|:|:..|.| .|.
Frog   207 LGPSTPLTLRTDG-----VMGEYEPKIEVHFPESVPSAKGSTVKLECFALGNPVPTITWRRADGK 266

  Fly   611 PLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYN 675
            |:.|.........||.|.|....|.|.|.|...|.|...|....:.....|.:...:.|......
Frog   267 PISRKVRRHRSSGVLEIPNFQQEDAGPYECVAENTRGKNMVRGQLTYFAPPTWVQKINDAHIAIE 331

  Fly   676 SDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQL 740
            .::.:.|:|...|.|:|||.||.:||.    ::.|..|....|||..: ...|..||||.|:|:.
Frog   332 ENILWECKASGRPKASYTWLKNGQRLQ----SKGRLQIDHGSLTITSV-NISDSGMYQCLAENKH 391

  Fly   741 KTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRR 805
            .|.:|||:|||:::.|.|.|..::........|:..|.|.|:|:|:|...|||..::........
Frog   392 GTIYSSAELRVIAVGPDFSKGFVKRVTLGKVGGSVLIECKPKASPKPSITWKKGKELQRESSRIS 456

  Fly   806 ILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHC 870
            ||..|||.||..::.|.|.|||.|||..||..|...::|....:.: .||..:.....:.|.|.|
Frog   457 ILDDGTLKISNLTKADAGSYTCTASNHFGTASSTGTLVVKDPTQVL-VPPSSMDVTVGESIVLPC 520

  Fly   871 EAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNR---------LTVHNTSMRDAGDYECVVK 926
            :.:.|..|||::.|..||:::....||.     .:.|         |.:.:..::.||.|.|:|.
Frog   521 QVSHDHSLDISFSWVFNGQLIDFQKDGE-----HFERVGGQDSAGDLMIRSIQLKHAGKYICLVH 580

  Fly   927 SAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVN 991
            ::|:::|:...:.:.|.||.|..:.|.:|:.|.|.:.|:.|..|...|..|::..||.::..|..
Frog   581 TSVDKLSAGADLIVRGPPGPPDALTVEEITDTTAQLSWMPGVDNHSPIIMYSVQARTPFSVGWQA 645

  Fly   992 VSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRN 1056
            |||..:..:...:|    |.||.|:||..|||.|.|:|::|||.||.||....|.|..|.:.|.|
Frog   646 VSTVPEVVDGRSFT----ATVVGLSPWVEYEFRVIAINEIGIGEPSPPSDKRRTEEALPEVTPAN 706

  Fly  1057 VGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNY 1121
            |.||||..|:|.|||:|:..:.|:..|..|.|.::..|.|.|....:...|.......|..|..
Frog   707 VSGGGGSKGELVITWEPVPEELQNGGGFGYVVAFRPFGTISWMQTVVASADSSRYVYRNESLPP- 770

  Fly  1122 YTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRG 1186
            ::.|||||...|:.|:||.|.:.|::|||:.|..||....:.:..:....|:|..:..|..  :|
Frog   771 FSPYEVKVGVYNNRGEGPFSPLTVVYSAEEEPGRAPAGVFSRSLTAWDIEVSWIAVPGSLS--KG 833

  Fly  1187 KLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERT 1251
            ::.|:.::|||...:|:::....:...:....:..||..|.|.:.|.|||:||.||.|......|
Frog   834 RIQGYEVRYWKQNEKEQNARKLRTLGNQTSTKLSHLQGHTLYHLNVRAYNSAGTGPASTTVNVTT 898

  Fly  1252 YRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRI-WE--SDQNMITANNTIVPI 1313
            .:..|.:||.:: ::..:.|.:.:.|..|:..:||..|:||:|.. |.  ...::|..|.|.|.:
Frog   899 RKPPPSQPPGNI-IWNSSNSKIILNWDQVTAQEDESEVKGYRVLYRWNRPGGASVIETNQTSVEL 962

  Fly  1314 GQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSP------TLHFQMGKTTRNGANTRHGHNINT 1372
                     :|...:.|.:.:.:.|.||:|..|.|      :..:..|    :||:|   .|..|
Frog   963 ---------SLPYDEDYIIEIRSISEGGEGSSSEPIRIPRISNAYAQG----SGAST---SNACT 1011

  Fly  1373 ALILSTLLLIST 1384
            ...:|||::..|
Frog  1012 LSAISTLMISLT 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/99 (28%)
		I-set	362..462	CDD:254352	28/100 (28%)
		Ig	466..559	CDD:299845	32/94 (34%)
		IG_like	584..657	CDD:214653	25/74 (34%)
		IGc2	586..645	CDD:197706	21/59 (36%)
		Ig	667..751	CDD:299845	29/83 (35%)
		IG_like	676..751	CDD:214653	28/74 (38%)
		IG_like	765..844	CDD:214653	28/78 (36%)
		Ig	773..844	CDD:299845	28/70 (40%)
		I-set	851..940	CDD:254352	23/97 (24%)
		Ig	866..944	CDD:299845	22/86 (26%)
		FN3	944..1043	CDD:238020	38/98 (39%)
		FN3	1053..1146	CDD:238020	33/92 (36%)
		fn3	1156..1244	CDD:278470	23/87 (26%)
		fn3	1259..1346	CDD:278470	22/89 (25%)
cntn4	NP_001135636.1	Ig	24..119	CDD:416386	30/105 (29%)
		Ig strand A	26..30	CDD:409353	1/3 (33%)
		Ig strand A'	33..38	CDD:409353	1/4 (25%)
		Ig strand B	44..52	CDD:409353	2/10 (20%)
		Ig strand C	57..63	CDD:409353	2/13 (15%)
		Ig strand C'	65..68	CDD:409353	0/2 (0%)
		Ig strand D	75..79	CDD:409353	2/3 (67%)
		Ig strand E	81..87	CDD:409353	3/5 (60%)
		Ig strand F	94..103	CDD:409353	3/8 (38%)
		Ig strand G	106..119	CDD:409353	5/12 (42%)
		Ig	128..213	CDD:416386	30/84 (36%)
		Ig strand A	129..134	CDD:409353	1/4 (25%)
		Ig strand B	138..144	CDD:409353	1/5 (20%)
		Ig strand C	152..158	CDD:409353	2/5 (40%)
		Ig strand C'	163..165	CDD:409353	0/1 (0%)
		Ig strand D	170..175	CDD:409353	3/4 (75%)
		Ig strand E	178..182	CDD:409353	2/3 (67%)
		Ig strand F	192..200	CDD:409353	4/7 (57%)
		Ig strand G	202..213	CDD:409353	3/10 (30%)
		IgI_3_Contactin	226..314	CDD:409357	31/87 (36%)
		Ig strand B	244..248	CDD:409357	1/3 (33%)
		Ig strand C	257..261	CDD:409357	0/3 (0%)
		Ig strand E	279..283	CDD:409357	2/3 (67%)
		Ig strand F	293..298	CDD:409357	2/4 (50%)
		Ig strand G	306..309	CDD:409357	1/2 (50%)
		Ig	319..402	CDD:416386	29/87 (33%)
		Ig strand A'	325..329	CDD:409353	1/3 (33%)
		Ig strand B	333..341	CDD:409353	1/7 (14%)
		Ig strand C	347..352	CDD:409353	3/4 (75%)
		Ig strand C'	354..357	CDD:409353	0/2 (0%)
		Ig strand D	362..366	CDD:409353	1/3 (33%)
		Ig strand E	368..373	CDD:409353	2/4 (50%)
		Ig strand F	382..389	CDD:409353	5/6 (83%)
		Ig strand G	393..402	CDD:409353	5/8 (63%)
		Ig5_Contactin	407..495	CDD:409358	31/87 (36%)
		Ig strand B	426..430	CDD:409358	1/3 (33%)
		Ig strand C	439..443	CDD:409358	0/3 (0%)
		Ig strand E	461..465	CDD:409358	3/3 (100%)
		Ig strand F	475..480	CDD:409358	3/4 (75%)
		Ig strand G	488..491	CDD:409358	1/2 (50%)
		Ig6_Contactin-4	497..598	CDD:409439	24/106 (23%)
		Ig strand B	516..520	CDD:409439	2/3 (67%)
		Ig strand C	531..535	CDD:409439	0/3 (0%)
		Ig strand E	560..564	CDD:409439	1/3 (33%)
		Ig strand F	574..579	CDD:409439	2/4 (50%)
		Ig strand G	587..590	CDD:409439	1/2 (50%)
		FN3	598..690	CDD:238020	36/95 (38%)
		FN3	704..796	CDD:238020	34/92 (37%)
		FN3	819..898	CDD:238020	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9051
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm48919
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060