DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and KLF4

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001300981.1	Gene:	KLF4 / 9314	HGNCID:	6348	Length:	513	Species:	Homo sapiens

Alignment Length:	273	Identity:	82/273 - (30%)
Similarity:	112/273 - (41%)	Gaps:	59/273 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PRT---VKQEPEAITIKTELASS---SFGH-DCDGDFSSASSSASSSSN--------SSKSCYEE 80
            |||   :||  ||::..|.|.:.   |.|| ....||.......|.::.        ||:.|:
Human   271 PRTCPKIKQ--EAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCH-- 331

  Fly    81 ALNHSSYTRTSTPLLDAAPHPVFSHPQSSPLDTHAAATASLAPPNQHAPFLSAASDLYYAAAAAA 145
                           .|.|.|...||       |.........|:|..|   ....|:|...:..
Human   332 ---------------PALPLPPGFHP-------HPGPNYPSFLPDQMQP---QVPPLHYQGQSRG 371

  Fly   146 AAAASTPTAV--PGFG-----MDPFTMGLMEQEYARVMAEDAQLKALNSRKQRPKKFKCPN-CDV 202
            ..|.:....|  |.||     :.|.:..|........|.|:.:.|  ..|:..|:|....: ||.
Human   372 FVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPK--RGRRSWPRKRTATHTCDY 434

  Fly   203 A-----FSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKF 262
            |     ::.:..||.|:|.||||:|:.||.:.||..|.|::|||||.|.|||.||:.|..|.:.|
Human   435 AGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAF 499

  Fly   263 GRRDHLKKHMKTH 275
            .|.|||..|||.|
Human   500 SRSDHLALHMKRH 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	31/71 (44%)
		zf-C2H2	195..217	CDD:278523	7/27 (26%)
		C2H2 Zn finger	197..217	CDD:275368	7/25 (28%)
		zf-H2C2_2	210..236	CDD:290200	14/25 (56%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	14/24 (58%)
		C2H2 Zn finger	255..275	CDD:275368	10/19 (53%)
KLF4	NP_001300981.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..45
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	101..109
		Interaction with ZNF296. /evidence=ECO:0000250\|UniProtKB:Q60793	416..513		44/99 (44%)
		COG5048	<425..508	CDD:227381	37/82 (45%)
		zf-C2H2	430..454	CDD:278523	7/23 (30%)
		C2H2 Zn finger	432..454	CDD:275368	7/21 (33%)
		C2H2 Zn finger	462..484	CDD:275368	12/21 (57%)
		Interaction with target DNA. /evidence=ECO:0000250	473..504		16/30 (53%)
		zf-H2C2_2	476..501	CDD:290200	14/24 (58%)
		C2H2 Zn finger	492..512	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1591573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920