DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hkb and SP6

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_001245177.1 Gene:SP6 / 80320 HGNCID:14530 Length:376 Species:Homo sapiens


Alignment Length:363 Identity:94/363 - (25%)
Similarity:127/363 - (34%) Gaps:141/363 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 INLHPPQTYSRLFRPWDTQRQAATSAAPRTVKQEPEAITIKT-----ELASSSFGHDCDGDFSSA 63
            ::|.|.|||           |..||         |||....:     ||.|...|.:.  |||..
Human    24 LDLQPLQTY-----------QGHTS---------PEAGDYPSPLQPGELQSLPLGPEV--DFSQG 66

  Fly    64 SSSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAPHPVFS------------------------ 104
            .....:||.  .:|.:        ..:.:||   ||.| ||                        
Human    67 YELPGASSR--VTCED--------LESDSPL---APGP-FSKLLQPDMSHHYESWFRPTHPGAED 117

  Fly   105 ------HPQSSPLD---THAAAT---------ASLA-----------PPNQHAPFLSAASDLYYA 140
                  ||.:|.:|   |..|.|         |.|.           ||:.||..|..|:...:.
Human   118 GSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHL 182

  Fly   141 AAAAAAAAASTPTAVPGFGMDPFTMGLMEQEYARVMAEDAQLKALNSRKQRPKK-----FKCPN- 199
            ......|.|....|....|:|              .:.|...:...||:..|:.     .:||| 
Human   183 LGPPDGAKALEVAAPESQGLD--------------SSLDGAARPKGSRRSVPRSSGQTVCRCPNC 233

  Fly   200 ---------------------------CDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRN 237
                                       |..|::....||.|:|.|:|:|||.|:...|||.|||:
Human   234 LEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRS 298

  Fly   238 EELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTH 275
            :||.||.:.|||.:.:||:.|.:.|.|.|||.||||||
Human   299 DELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTH 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/93 (33%)
zf-C2H2 195..217 CDD:278523 9/49 (18%)
C2H2 Zn finger 197..217 CDD:275368 9/47 (19%)
zf-H2C2_2 210..236 CDD:290200 14/25 (56%)
C2H2 Zn finger 225..247 CDD:275368 11/21 (52%)
zf-H2C2_2 239..264 CDD:290200 11/24 (46%)
C2H2 Zn finger 255..275 CDD:275368 11/19 (58%)
SP6NP_001245177.1 SP6_N 1..255 CDD:411693 55/280 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70 18/67 (27%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 118..126 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..223 13/69 (19%)
C2H2 Zn finger 259..278 CDD:275368 6/18 (33%)
COG5048 <261..>336 CDD:227381 37/74 (50%)
C2H2 Zn finger 286..308 CDD:275368 11/21 (52%)
C2H2 Zn finger 316..336 CDD:275368 11/19 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..376 4/4 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 101 1.000 Inparanoid score I4986
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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