DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and sp5b

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_005172147.1	Gene:	sp5b / 799504	ZFINID:	ZDB-GENE-131231-1	Length:	291	Species:	Danio rerio

Alignment Length:	285	Identity:	80/285 - (28%)
Similarity:	117/285 - (41%)	Gaps:	76/285 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SASSSASSSSNSSKSCYEEALNH----SSYTRTSTPLLDAAPHPVFSHPQSSPLDTH-AAATASL 121
            ::||:..|..:|.....|:..|.    |....:..|.  |:|:.:| ||..|...|| :.:|.|:
Zfish    14 TSSSTPESIKSSPLMLLEDTCNRIGRASQSMESYIPY--ASPNKLF-HPWRSTDSTHLSQSTFSI 75

  Fly   122 APPNQHAPFLS--AASDLYYAAAAAAAAAASTPTAVPGFGMDPFTMGLMEQEYARVMAED----- 179
            .|.:|..|...  ..|.|......::..:...||..          ||:..:  |.:|.|
Zfish    76 PPLHQDMPLTEHFDCSPLKMLPCPSSCISTCVPTHT----------GLVHAQ--RHLARDDIQWW 128

  Fly   180 ---------------------------AQLKALNSRKQRPKKFKCPNCD---------------- 201
                                       :|: .|||:.::.::..||||.
Zfish   129 SSANHSSAHFQLTRGWILGQPEFGHYQSQI-LLNSKSRQSRRCMCPNCQKNADTPGRRKQHACHI 192

  Fly   202 ----VAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKF 262
                ..:.....||.|:|.|.|||||.|....|||:|||::||.||.|.|||.:.:.|..|.|:|
Zfish   193 PGCAKVYGKTSHLKAHLRWHAGERPFICSWMFCGKSFTRSDELQRHLRTHTGEKRFTCPDCSKRF 257

  Fly   263 GRRDHLKKHMKTH-MPQERQLGPSI 286
            .|.|||.||:||| |.:.|.|.|.:
Zfish   258 MRSDHLAKHLKTHLMRKNRGLFPML 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	31/85 (36%)
		zf-C2H2	195..217	CDD:278523	8/41 (20%)
		C2H2 Zn finger	197..217	CDD:275368	8/39 (21%)
		zf-H2C2_2	210..236	CDD:290200	15/25 (60%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	11/19 (58%)
sp5b	XP_005172147.1	C2H2 Zn finger	193..212	CDD:275368	4/18 (22%)
		C2H2 Zn finger	220..242	CDD:275368	12/21 (57%)
		zf-H2C2_2	234..257	CDD:290200	11/22 (50%)
		zf-C2H2	248..270	CDD:278523	11/21 (52%)
		C2H2 Zn finger	250..270	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910