DRSC/TRiP Functional Genomics Resources

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Protein Alignment hkb and WT1

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_077744.4 Gene:WT1 / 7490 HGNCID:12796 Length:522 Species:Homo sapiens


Alignment Length:336 Identity:83/336 - (24%)
Similarity:128/336 - (38%) Gaps:96/336 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 VKQEPE--AITIKTELASSSFGHDCDGDFSSASSS-----------ASSSSNSSK---------S 76
            :||||.  ......|...|:|.....|.|:..:.:           :.:||..::         |
Human   145 IKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPS 209

  Fly    77 CYEE--ALNHSSYTRTS---------TPLLDAAPHPVFSHPQSSPLDTHAA---ATASLAPP--N 125
            |.|.  |:.:..|:..:         ||...||..|..|.....|:....:   ...|:.||  .
Human   210 CLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYG 274

  Fly   126 QHAPFLSA------------ASDLYY---------------AAAAAAAAAASTPTAV-------- 155
            .|.|..|.            :||..|               ..|.....||.:.::|        
Human   275 CHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSN 339

  Fly   156 --PGFGMDPFTMGLM---------------EQEYARV--MAEDAQLKALNSRKQRPKKFKC--PN 199
              .|:..|..|..::               .|:..||  :|......|..:.::||  |.|  |.
Human   340 HSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRP--FMCAYPG 402

  Fly   200 CDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGR 264
            |:..:.....|:.|.|.||||:|::||...|.:.|:|:::|.||:|.|||::|:.|..|.:||.|
Human   403 CNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSR 467

  Fly   265 RDHLKKHMKTH 275
            .||||.|.:||
Human   468 SDHLKTHTRTH 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 27/67 (40%)
zf-C2H2 195..217 CDD:278523 7/23 (30%)
C2H2 Zn finger 197..217 CDD:275368 6/21 (29%)
zf-H2C2_2 210..236 CDD:290200 12/25 (48%)
C2H2 Zn finger 225..247 CDD:275368 9/21 (43%)
zf-H2C2_2 239..264 CDD:290200 12/24 (50%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)
WT1NP_077744.4 WT1 74..394 CDD:308009 44/248 (18%)
COG5048 386..>514 CDD:227381 40/95 (42%)
C2H2 Zn finger 401..420 CDD:275368 5/18 (28%)
C2H2 Zn finger 428..450 CDD:275368 9/21 (43%)
C2H2 Zn finger 458..478 CDD:275368 10/19 (53%)
C2H2 Zn finger 489..511 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 101 1.000 Inparanoid score I4986
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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