DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and sp2

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001093452.2	Gene:	sp2 / 556835	ZFINID:	ZDB-GENE-080410-1	Length:	610	Species:	Danio rerio

Alignment Length:	305	Identity:	81/305 - (26%)
Similarity:	115/305 - (37%)	Gaps:	87/305 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QRQAATSAAPRTVKQEPEAITIKTELASSSFGHDCDGDFSSASSSASSSSNSSKSCYEEALNHSS 86
            |||..|.:. :....||..:.|||          ..|::.:..                 :..::
Zfish   338 QRQTVTPSV-QVSPPEPTQVLIKT----------ASGEWQAVQ-----------------IQETT 374

  Fly    87 YTRTSTPLLDAAPHPVFSHPQSSPLDTHAAAT-ASLAPPNQHAPFLSAASDLYYAAAAAAAAAAS 150
            .|..:||.....|..|....|:.   |....| ..:||.......|:||.   .|:||.|....:
Zfish   375 VTTPTTPTSTPTPAVVTKKVQTG---TRKERTLPKIAPAGGGLITLNAAQ---LASAAQAVQTIN 433

  Fly   151 ----------------------TPTAVPGFGMDPFTMGLMEQEYARVMAEDAQLKALN-----SR 188
                                  |...||..|:.   :|.::.:...:..|..|..||.     ..
Zfish   434 INGVQVQGVPVTITNAGGQQHLTVQTVPSAGLQ---LGSVQTQTQTMQIEQTQTLALELQTQPGE 495

  Fly   189 KQRPKKFKCPN----------------------CDVAFSNNGQLKGHIRIHTGERPFKCDVNTCG 231
            |:|.....|||                      |:..|.....|:.|:|:|||||||.|:...||
Zfish   496 KKRRMACTCPNCKDAEKKPGEVGKRKHICHIAGCEKTFRKTSLLRAHVRLHTGERPFVCNWVFCG 560

  Fly   232 KTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHM 276
            |.|||::||.||.|.|||.:.:.|:.|.|:|.|.|||.||.|||:
Zfish   561 KRFTRSDELQRHARTHTGDKRFECNKCQKRFMRSDHLTKHYKTHI 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	32/87 (37%)
		zf-C2H2	195..217	CDD:278523	8/43 (19%)
		C2H2 Zn finger	197..217	CDD:275368	8/41 (20%)
		zf-H2C2_2	210..236	CDD:290200	15/25 (60%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	11/19 (58%)
sp2	NP_001093452.2	C2H2 Zn finger	524..546	CDD:275368	5/21 (24%)
		COG5048	<529..>584	CDD:227381	27/54 (50%)
		zf-H2C2_2	539..565	CDD:290200	15/25 (60%)
		C2H2 Zn finger	554..576	CDD:275368	12/21 (57%)
		zf-H2C2_2	568..591	CDD:290200	11/22 (50%)
		zf-C2H2	582..604	CDD:278523	11/21 (52%)
		C2H2 Zn finger	584..604	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910