DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and SP5

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_011509461.1	Gene:	SP5 / 389058	HGNCID:	14529	Length:	454	Species:	Homo sapiens

Alignment Length:	336	Identity:	102/336 - (30%)
Similarity:	138/336 - (41%)	Gaps:	85/336 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SRLFRPWDTQRQAATSAA---PR-TVKQEPEAITIKTELASSSFG--HDC----------DGDFS 61
            ||||.||.....|.:..|   |. ::...|:    ||.| ..|||  |:.          ..:||
Human   123 SRLFHPWTADMPAHSPGALPPPHPSLGLTPQ----KTHL-QPSFGAAHELPLTPPADPSYPYEFS 182

  Fly    62 SASSSASSSSNSSKSCYEEALNHSS-------YTRTSTPLLDAAPHPVFSH--PQSSPLD----- 112
            ......||.:....||....:.:::       |:....|.....|.|....  |..:|.|
Human   183 PVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWS 247

  Fly   113 ---THAAATASLAPPN---------QHAPFLSAASDLYYAAAAAAAAAASTPTAVPGFGMDPFTM 165
               ..|...||..|.:         .|||...|:     ||||||||||    ...|..:.|...
Human   248 IPQAGAGPGASGVPGSGLSGACAGAPHAPRFPAS-----AAAAAAAAAA----LQRGLVLGPSDF 303

  Fly   166 GLMEQEYARVMAEDAQLKALNSRKQRPKKFKCPNCDVA------------------------FSN 206
            ...:.:.|.::...|.|.|   ..:|.::.:||||..|                        :..
Human   304 AQYQSQIAALLQTKAPLAA---TARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGK 365

  Fly   207 NGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKH 271
            ...||.|:|.|||||||.|:...|||:|||::||.||.|.|||.:.:.|..|||:|.|.|||.||
Human   366 TSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKH 430

  Fly   272 MKTHMPQERQL 282
            :|||  |.::|
Human   431 VKTH--QNKKL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	34/89 (38%)
		zf-C2H2	195..217	CDD:278523	9/45 (20%)
		C2H2 Zn finger	197..217	CDD:275368	9/43 (21%)
		zf-H2C2_2	210..236	CDD:290200	16/25 (64%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	13/24 (54%)
		C2H2 Zn finger	255..275	CDD:275368	12/19 (63%)
SP5	XP_011509461.1	C2H2 Zn finger	357..376	CDD:275368	4/18 (22%)
		COG5048	<367..440	CDD:227381	42/75 (56%)
		zf-H2C2_2	368..395	CDD:290200	16/26 (62%)
		C2H2 Zn finger	384..406	CDD:275368	12/21 (57%)
		zf-H2C2_2	398..421	CDD:290200	12/22 (55%)
		zf-C2H2	412..434	CDD:278523	12/21 (57%)
		C2H2 Zn finger	414..434	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910