DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and sp8b

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_005158015.1	Gene:	sp8b / 324931	ZFINID:	ZDB-GENE-030131-3654	Length:	455	Species:	Danio rerio

Alignment Length:	260	Identity:	84/260 - (32%)
Similarity:	109/260 - (41%)	Gaps:	67/260 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QEPEAITIKTELASSSFGHDCDGDFSSASSSASSSSNSSKSCYEEALNHSSYTRTSTP-LLDAAP 99
            |.|....::|.|.|        |...::..|.....||..|    :|:||:::.:::| ||....
Zfish   185 QNPNGAALQTSLHS--------GGLQTSLHSPLGGYNSDYS----SLSHSAFSTSASPHLLTTGQ 237

  Fly   100 H------PVF-SHPQSSPLDTHAAA--------TASLAPPNQHAPFLSAASDLYYAAAAAAAAAA 149
            |      ||. |:|.|||.....|.        ||||           |.|....|...:..|..
Zfish   238 HLMDGFKPVLSSYPDSSPSPLGGAGGSMLTGGPTASL-----------AGSPRSSARRYSGRATC 291

  Fly   150 STPTAVPGFGMDPFTMGLMEQEYARVMAEDAQL--KALNSRKQRPKKFKC--PNCDVAFSNNGQL 210
            ..|..               ||..|:....|.|  |.|:|         |  |.|...:.....|
Zfish   292 DCPNC---------------QEAERLGPAGASLRRKGLHS---------CHIPGCGKVYGKTSHL 332

  Fly   211 KGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTH 275
            |.|:|.|||||||.|:...|||.|||::||.||.|.|||.:.:.|..|.|:|.|.|||.||:|||
Zfish   333 KAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTH 397

Fly 276 275
Zfish 398 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	31/67 (46%)
		zf-C2H2	195..217	CDD:278523	7/23 (30%)
		C2H2 Zn finger	197..217	CDD:275368	7/21 (33%)
		zf-H2C2_2	210..236	CDD:290200	16/25 (64%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	11/19 (58%)
sp8b	XP_005158015.1	C2H2 Zn finger	320..339	CDD:275368	6/18 (33%)
		zf-H2C2_2	331..358	CDD:290200	16/26 (62%)
		C2H2 Zn finger	347..369	CDD:275368	12/21 (57%)
		zf-H2C2_2	361..384	CDD:290200	11/22 (50%)
		zf-C2H2	375..397	CDD:278523	11/21 (52%)
		C2H2 Zn finger	377..397	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910