DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and Sp1

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	99/329 - (30%)
Similarity:	129/329 - (39%)	Gaps:	97/329 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ITIKTELASS--SFGHDCDGDFSSASSSASSSSNSS-KSCYEEALNHSSYTRTSTPLLD------ 96
            ||....||||  :.|....|..||||.|.|||:.|: .:.|...|   .:..|||..:|
  Fly   142 ITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDL---YFPNTSTSNMDNHHMHQ 203

  Fly    97 ----------AAPHPVFS-HPQSSPL----------------DTHAAATA--SLAPPNQHAPFLS 132
                      ||...|:| ||...|.                |.|:||.:  .:.....|:...:
  Fly   204 GLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMAN 268

  Fly   133 AASDLY-------------------------------------------YAAAAAAAAAASTPTA 154
            .||:.|                                           :::.:||||||:|..|
  Fly   269 YASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAA 333

  Fly   155 VPG---FGMDPFTMGLMEQ-EYA-RVM--------AEDAQLKALNSRKQRPKKFKCPNCDVAFSN 206
            ..|   .|..|.|.....| .|| |..        ||......::.||:.......|.|...:..
  Fly   334 AAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGK 398

  Fly   207 NGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKH 271
            ...||.|:|.|||||||.|:...|||.|||::||.||.|.|||.:.:.|..|.|:|.|.|||.||
  Fly   399 TSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKH 463

  Fly   272 MKTH 275
            :|||
  Fly   464 VKTH 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	30/65 (46%)
		zf-C2H2	195..217	CDD:278523	6/21 (29%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		zf-H2C2_2	210..236	CDD:290200	16/25 (64%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	11/19 (58%)
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	6/18 (33%)
		zf-H2C2_2	401..428	CDD:290200	16/26 (62%)
		C2H2 Zn finger	417..439	CDD:275368	12/21 (57%)
		zf-H2C2_2	431..454	CDD:290200	11/22 (50%)
		zf-C2H2	445..467	CDD:278523	11/21 (52%)
		C2H2 Zn finger	447..467	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010