DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and KLF15

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_011511045.1	Gene:	KLF15 / 28999	HGNCID:	14536	Length:	435	Species:	Homo sapiens

Alignment Length:	304	Identity:	82/304 - (26%)
Similarity:	114/304 - (37%)	Gaps:	84/304 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NLHP-----PQTYSRLFRPWDTQRQAATSAAPRTVKQEPEAITIKTELASSSFGHD-CDGDFSSA 63
            |:.|     |:..|:     |....:..||.|.           |:.|...|.|.: |......|
Human   170 NMEPGVKEVPEGNSK-----DLDACSQLSAGPH-----------KSHLHPGSSGRERCSPPPGGA 218

  Fly    64 SSSASSSSNSSKSCYEEALNHSSYTRTSTP------LLDAAPHPVFSHPQSSPLDTHAAATASLA 122
            |:..:......                .||      ||...|.||.....:.|      |:...|
Human   219 SAGGAQGPGGG----------------PTPDGPIPVLLQIQPVPVKQESGTGP------ASPGQA 261

  Fly   123 PPNQH---------------APFLSAASDLYYAAAAAAAAAASTPTAVPGFGMDPFTMG----LM 168
            |.|..               .|.:..:|:|  ...:.....|..|.|....|..|...|    ||
Human   262 PENVKVAQLLVNIQGQTFALVPQVVPSSNL--NLPSKFVRIAPVPIAAKPVGSGPLGPGPAGLLM 324

  Fly   169 EQEYARVMAEDAQLKALNSRKQRPKKFKC--PNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCG 231
            .|::.:           |...:..|..||  |.|...::.:..||.|:|.||||:||.|....||
Human   325 GQKFPK-----------NPAAELIKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCG 378

  Fly   232 KTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTH 275
            ..|:|::||:||:|.|:|::||.|..|.|||.|.|||.||:|.|
Human   379 WRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVH 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	30/67 (45%)
		zf-C2H2	195..217	CDD:278523	8/23 (35%)
		C2H2 Zn finger	197..217	CDD:275368	7/21 (33%)
		zf-H2C2_2	210..236	CDD:290200	14/25 (56%)
		C2H2 Zn finger	225..247	CDD:275368	10/21 (48%)
		zf-H2C2_2	239..264	CDD:290200	14/24 (58%)
		C2H2 Zn finger	255..275	CDD:275368	12/19 (63%)
KLF15	XP_011511045.1	zf-C2H2	340..364	CDD:278523	8/23 (35%)
		zf-C2H2_8	342..421	CDD:292531	38/78 (49%)
		C2H2 Zn finger	342..364	CDD:275368	7/21 (33%)
		zf-H2C2_2	356..383	CDD:290200	14/26 (54%)
		C2H2 Zn finger	372..394	CDD:275368	10/21 (48%)
		zf-H2C2_2	386..411	CDD:290200	14/24 (58%)
		C2H2 Zn finger	402..422	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4986
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960