DRSC/TRiP Functional Genomics Resources

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Protein Alignment hkb and Sp1

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_036787.2 Gene:Sp1 / 24790 RGDID:3738 Length:786 Species:Rattus norvegicus


Alignment Length:323 Identity:87/323 - (26%)
Similarity:122/323 - (37%) Gaps:102/323 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 QRQAATSAAPRTVK----------------------QEPEAITIKTELASSSFGHDCDGDFSSAS 64
            |.||..::.|..::                      |.|:|.||..            ......|
  Rat   440 QLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITL------------APMQGVS 492

  Fly    65 SSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAPHPVFSHPQSSPLDTHAAATASLAPPNQHAP 129
            ...:||||:                |.||:..||..|      :..:..:||..:|:  |.....
  Rat   493 LGQTSSSNT----------------TLTPIASAASIP------AGTVTVNAAQLSSM--PGLQTI 533

  Fly   130 FLSA---ASDLYYAAAAAAAAAASTP---------TAVPGFGMDPFTMGLMEQEYARVMAEDAQL 182
            .|||   :....:.......|.|:||         ....|.|:...|.|..|.|    .:.|.|.
  Rat   534 NLSALGTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGE----NSPDPQP 594

  Fly   183 KALNSRKQRPKKFKCP------------------------NCDVAFSNNGQLKGHIRIHTGERPF 223
            :|  .|:.|.:...||                        .|...:.....|:.|:|.|||||||
  Rat   595 QA--GRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPF 657

  Fly   224 KCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHMPQERQLGPSI 286
            .|:.:.|||.|||::||.||||.|||.:.:.|..|.|:|.|.|||.||:|||  |.::.||.:
  Rat   658 MCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH--QNKKGGPGV 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/89 (35%)
zf-C2H2 195..217 CDD:278523 6/45 (13%)
C2H2 Zn finger 197..217 CDD:275368 6/43 (14%)
zf-H2C2_2 210..236 CDD:290200 15/25 (60%)
C2H2 Zn finger 225..247 CDD:275368 13/21 (62%)
zf-H2C2_2 239..264 CDD:290200 13/24 (54%)
C2H2 Zn finger 255..275 CDD:275368 11/19 (58%)
Sp1NP_036787.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94
Repressor domain. /evidence=ECO:0000250 2..83
SP1-4_N 55..628 CDD:425404 44/229 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..143
Transactivation domain A (Gln-rich). /evidence=ECO:0000250 147..252
Transactivation domain B (Gln-rich). /evidence=ECO:0000250 262..496 10/67 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..303
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..397
9aaTAD. /evidence=ECO:0000250|UniProtKB:P08047 463..471 0/7 (0%)
Transactivation domain C (highly charged). /evidence=ECO:0000250 497..611 34/143 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 562..600 10/43 (23%)
VZV IE62-binding. /evidence=ECO:0000250 620..786 43/101 (43%)
zf-C2H2 627..651 CDD:395048 4/23 (17%)
C2H2 Zn finger 629..651 CDD:275368 4/21 (19%)
zf-H2C2_2 643..670 CDD:404364 15/26 (58%)
C2H2 Zn finger 659..681 CDD:275368 13/21 (62%)
zf-H2C2_2 673..696 CDD:404364 12/22 (55%)
zf-C2H2 687..709 CDD:395048 11/21 (52%)
C2H2 Zn finger 689..709 CDD:275368 11/19 (58%)
Domain D. /evidence=ECO:0000250 709..786 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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