DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hkb and Egr1

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_036683.1 Gene:Egr1 / 24330 RGDID:2544 Length:508 Species:Rattus norvegicus


Alignment Length:328 Identity:94/328 - (28%)
Similarity:135/328 - (41%) Gaps:89/328 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PPQTYSRLFRPWDTQRQAATSAAP---RTVKQEP------EAITIKTELASSSFGHDCDGDFSSA 63
            ||.||:..|         :...||   .|:..||      ..:::.....|||         |:.
  Rat   101 PPITYTGRF---------SLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSS---------SAP 147

  Fly    64 SSSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAP------HPVFSHPQSSPLDTHAAATASLA 122
            |.:|||||::|:|   ..|:.:..:..|:|:..|||      ..:|..|||......|.......
  Rat   148 SPAASSSSSASQS---PPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYP 209

  Fly   123 PPNQHAP-------------FLSAASDLYYAAAAAAAAAASTPTAVPGFGMD-----PFTMGLME 169
            ||...|.             |.....||          :..||...|..|::     |....|..
  Rat   210 PPAYPATKGGFQVPMIPDYLFPQQQGDL----------SLGTPDQKPFQGLENRTQQPSLTPLST 264

  Fly   170 QEYARVMAEDAQLKALNSRKQ--------------RPKK-------FKCP--NCDVAFSNNGQLK 211
            .:.....:....|||||:..|              ||.|       :.||  :||..||.:.:|.
  Rat   265 IKAFATQSGSQDLKALNNTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELT 329

  Fly   212 GHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHM 276
            .|||||||::||:|.:  |.:.|:|::.||.|.|.|||.:|:.|..||:||.|.|..|:|.|.|:
  Rat   330 RHIRIHTGQKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHL 392

  Fly   277 PQE 279
            .|:
  Rat   393 RQK 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/67 (46%)
zf-C2H2 195..217 CDD:278523 10/23 (43%)
C2H2 Zn finger 197..217 CDD:275368 10/21 (48%)
zf-H2C2_2 210..236 CDD:290200 13/25 (52%)
C2H2 Zn finger 225..247 CDD:275368 8/21 (38%)
zf-H2C2_2 239..264 CDD:290200 13/24 (54%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)
Egr1NP_036683.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..78
DUF3446 107..182 CDD:288757 24/95 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..210 23/85 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..311 3/18 (17%)
zf-C2H2 311..335 CDD:278523 10/23 (43%)
C2H2 Zn finger 313..335 CDD:275368 10/21 (48%)
zf-H2C2_2 327..352 CDD:290200 13/26 (50%)
COG5048 338..>396 CDD:227381 26/60 (43%)
C2H2 Zn finger 343..363 CDD:275368 8/21 (38%)
zf-H2C2_2 355..380 CDD:290200 13/24 (54%)
C2H2 Zn finger 371..391 CDD:275368 10/19 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..453 6/14 (43%)
7 X 8 AA tandem repeats of [TS](2)-[FY]-[PS]-S-P-[GSAV]-X 413..468
DUF3432 420..495 CDD:288743
BES1_N <424..453 CDD:283367
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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