DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hkb and Sp4

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_033265.4 Gene:Sp4 / 20688 MGIID:107595 Length:782 Species:Mus musculus


Alignment Length:333 Identity:82/333 - (24%)
Similarity:122/333 - (36%) Gaps:89/333 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PPQTYSRLFRPWDTQRQAATSAAPRTVKQE-----------PEAITIKTELASSSFGHDCDGDFS 61
            |||::           |..:....:|::|:           |..:.|:....:.|      |..|
Mouse   419 PPQSF-----------QLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPS------GQIS 466

  Fly    62 SASSSASSSSNSSKSCYEEALNHSSYTRT------STPLLDAAPHPVFSHPQSSPLDTHAAATAS 120
            ..:....:..:.|....:.|......|.|      .|.|...||..|    ..:|:..:.|..||
Mouse   467 WQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAV----AGAPITLNTAQLAS 527

  Fly   121 LAPPN----------------QHAP--FLSAASDLYYAAAAAAAAAASTPTAVPGFGMDPFTMGL 167
            :  ||                |..|  ..|.|.............|...|..|...|:...|:|.
Mouse   528 V--PNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGA 590

  Fly   168 ME-QEYARVMAEDAQLKALNSRKQRPKKFK-----CPN------------------------CDV 202
            :. .:..:|..:..| :..::..|..|:.:     |||                        |..
Mouse   591 VSPDQLTQVHLQQGQ-QTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGK 654

  Fly   203 AFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDH 267
            .:.....|:.|:|.|||||||.|:...|||.|||::||.||:|.|||.:.:.|..|.|:|.|.||
Mouse   655 VYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDH 719

  Fly   268 LKKHMKTH 275
            |.||:|||
Mouse   720 LSKHVKTH 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/94 (33%)
zf-C2H2 195..217 CDD:278523 7/50 (14%)
C2H2 Zn finger 197..217 CDD:275368 7/43 (16%)
zf-H2C2_2 210..236 CDD:290200 15/25 (60%)
C2H2 Zn finger 225..247 CDD:275368 12/21 (57%)
zf-H2C2_2 239..264 CDD:290200 12/24 (50%)
C2H2 Zn finger 255..275 CDD:275368 11/19 (58%)
Sp4NP_033265.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..148
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..385
9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:Q02446 465..473 1/7 (14%)
C2H2 Zn finger 647..669 CDD:275368 4/21 (19%)
COG5048 <660..731 CDD:227381 38/68 (56%)
zf-H2C2_2 661..688 CDD:290200 15/26 (58%)
C2H2 Zn finger 677..699 CDD:275368 12/21 (57%)
zf-H2C2_2 691..714 CDD:290200 11/22 (50%)
zf-C2H2 705..727 CDD:278523 11/21 (52%)
C2H2 Zn finger 707..727 CDD:275368 11/19 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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