DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hkb and EGR1

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001955.1	Gene:	EGR1 / 1958	HGNCID:	3238	Length:	543	Species:	Homo sapiens

Alignment Length:	327	Identity:	95/327 - (29%)
Similarity:	134/327 - (40%)	Gaps:	88/327 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PPQTYSRLFRPWDTQRQAATSAAP---RTVKQEP-----EAITIKTELASSSFGHDCDGDFSSAS 64
            ||.||:..|         :...||   .|:..||     ..:...|...:||         |||.
Human   129 PPITYTGRF---------SLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASS---------SSAP 175

  Fly    65 SSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAP------HPVFSHPQSSPLDTHAAATASLAP 123
            |.|:||:::|:|   ..|:.:..:..|:|:..|||      ..:|..|||......|.......|
Human   176 SPAASSASASQS---PPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPP 237

  Fly   124 PNQHAP-------------FLSAASDLYYAAAAAAAAAASTPTAVPGFGMDPFTMGLMEQEYARV 175
            |...|.             |.....||          ...||...|..|::..|........:.:
Human   238 PAYPAAKGGFQVPMIPDYLFPQQQGDL----------GLGTPDQKPFQGLESRTQQPSLTPLSTI 292

  Fly   176 MAEDAQ-----LKALNSRKQ--------------RPKK-------FKCP--NCDVAFSNNGQLKG 212
            .|...|     |||||:..|              ||.|       :.||  :||..||.:.:|..
Human   293 KAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTR 357

  Fly   213 HIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHMP 277
            |||||||::||:|.:  |.:.|:|::.||.|.|.|||.:|:.|..||:||.|.|..|:|.|.|:.
Human   358 HIRIHTGQKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR 420

  Fly   278 QE 279
            |:
Human   421 QK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	31/67 (46%)
		zf-C2H2	195..217	CDD:278523	10/23 (43%)
		C2H2 Zn finger	197..217	CDD:275368	10/21 (48%)
		zf-H2C2_2	210..236	CDD:290200	13/25 (52%)
		C2H2 Zn finger	225..247	CDD:275368	8/21 (38%)
		zf-H2C2_2	239..264	CDD:290200	13/24 (54%)
		C2H2 Zn finger	255..275	CDD:275368	10/19 (53%)
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105
		DUF3446	135..209	CDD:314753	24/94 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..213		18/59 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..284		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..339		3/20 (15%)
		zf-C2H2	338..362	CDD:306579	10/23 (43%)
		C2H2 Zn finger	340..362	CDD:275368	10/21 (48%)
		zf-H2C2_2	354..379	CDD:316026	13/26 (50%)
		C2H2 Zn finger	370..390	CDD:275368	8/21 (38%)
		zf-H2C2_2	382..407	CDD:316026	13/24 (54%)
		C2H2 Zn finger	398..418	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..487		6/14 (43%)
		DUF3432	447..530	CDD:288743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910