DRSC/TRiP Functional Genomics Resources

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Protein Alignment hkb and Egr1

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_031939.1 Gene:Egr1 / 13653 MGIID:95295 Length:533 Species:Mus musculus


Alignment Length:348 Identity:99/348 - (28%)
Similarity:143/348 - (41%) Gaps:91/348 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PPQTYSRLFRPWDTQRQAATSAAP---RTVKQEP------EAITIKTELASSSFGHDCDGDFSSA 63
            ||.||:..|         :...||   .|:..||      ..:::.....|||         |:.
Mouse   126 PPITYTGRF---------SLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSS---------SAP 172

  Fly    64 SSSASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAP------HPVFSHPQSSPLDTHAAATASLA 122
            |.:|||||::|:|   ..|:.:..:..|:|:..|||      ..:|..|||......|.......
Mouse   173 SPAASSSSSASQS---PPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYP 234

  Fly   123 PPNQHAP-------------FLSAASDLYYAAAAAAAAAASTPTAVPGFGMD-----PFTMGLME 169
            ||...|.             |.....||          :..||...|..|::     |....|..
Mouse   235 PPAYPATKGGFQVPMIPDYLFPQQQGDL----------SLGTPDQKPFQGLENRTQQPSLTPLST 289

  Fly   170 QEYARVMAEDAQLKALNSRKQ--------------RPKK-------FKCP--NCDVAFSNNGQLK 211
            .:.....:....|||||:..|              ||.|       :.||  :||..||.:.:|.
Mouse   290 IKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELT 354

  Fly   212 GHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHM 276
            .|||||||::||:|.:  |.:.|:|::.||.|.|.|||.:|:.|..||:||.|.|..|:|.|.|:
Mouse   355 RHIRIHTGQKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHL 417

  Fly   277 PQ-ERQLGPSIFV-PMYSYLYGY 297
            .| :::...|:.. |..|.|..|
Mouse   418 RQKDKKADKSVVASPAASSLSSY 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/67 (46%)
zf-C2H2 195..217 CDD:278523 10/23 (43%)
C2H2 Zn finger 197..217 CDD:275368 10/21 (48%)
zf-H2C2_2 210..236 CDD:290200 13/25 (52%)
C2H2 Zn finger 225..247 CDD:275368 8/21 (38%)
zf-H2C2_2 239..264 CDD:290200 13/24 (54%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)
Egr1NP_031939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94
DUF3446 132..207 CDD:288757 24/95 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..237 24/87 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..336 3/19 (16%)
zf-C2H2 336..360 CDD:278523 10/23 (43%)
C2H2 Zn finger 338..360 CDD:275368 10/21 (48%)
zf-H2C2_2 352..377 CDD:290200 13/26 (50%)
COG5048 363..>421 CDD:227381 26/59 (44%)
C2H2 Zn finger 368..388 CDD:275368 8/21 (38%)
zf-H2C2_2 380..405 CDD:290200 13/24 (54%)
C2H2 Zn finger 396..416 CDD:275368 10/19 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..478 11/34 (32%)
DUF3432 426..520 CDD:288743 5/15 (33%)
BES1_N <441..478 CDD:283367 99/348 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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