DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hkb and KLF14

DIOPT Version :9

Sequence 1:	NP_524221.1	Gene:	hkb / 40549	FlyBaseID:	FBgn0261434	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_619638.2	Gene:	KLF14 / 136259	HGNCID:	23025	Length:	323	Species:	Homo sapiens

Alignment Length:	296	Identity:	85/296 - (28%)
Similarity:	115/296 - (38%)	Gaps:	53/296 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STINLHPPQTYSRLFRPWDTQRQAATSAAPRTVKQEPEAITIKTELASSSFGHDCDGDFSSASSS 66
            |.:...||:  |.|..| .....|:....|:.....|.|......|.::|...|..|.....|..
Human    41 SEVGAAPPE--SALPGP-GPPGPASVPQLPQVPAPSPGAGGAAPHLLAASVWADLRGSSGEGSWE 102

  Fly    67 ASSSSNSSKSCYEEALNHSSYTRTSTPLLDAAPHPVFSHPQSSPLDTHAAATASLAPPNQHAPFL 131
            .|..:..:.|.:.:.:..|    ..||..:.||               |:..|::..|
Human   103 NSGEAPRASSGFSDPIPCS----VQTPCSELAP---------------ASGAAAVCAP------- 141

  Fly   132 SAASDLYYAAAAAAAAAASTPTAVPGFGMDPFTMGLMEQEYARVMAEDAQLKALNSRKQRP--KK 194
            .::||.  .|..:|.||...|.|..||.......|          ...|..:|...|...|  |:
Human   142 ESSSDA--PAVPSAPAAPGAPAASGGFSGGALGAG----------PAPAADQAPRRRSVTPAAKR 194

  Fly   195 FKC--PNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSA 257
            .:|  |.|..|:..:..||.|.|.|||||||.||...|.|.|||::||.||.|.|||.:.:.|..
Human   195 HQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRFSCPL 259

  Fly   258 CGKKFGRRDHLKKHMKTHMPQERQLGPSIFVPMYSY 293
            |.|:|.|.|||.||.:.|        |:....|..|
Human   260 CPKQFSRSDHLTKHARRH--------PTYHPDMIEY 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	32/67 (48%)
		zf-C2H2	195..217	CDD:278523	8/23 (35%)
		C2H2 Zn finger	197..217	CDD:275368	8/21 (38%)
		zf-H2C2_2	210..236	CDD:290200	16/25 (64%)
		C2H2 Zn finger	225..247	CDD:275368	12/21 (57%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	10/19 (53%)
KLF14	NP_619638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..80		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..195		7/38 (18%)
		COG5048	198..>283	CDD:227381	41/92 (45%)
		C2H2 Zn finger	200..219	CDD:275368	7/18 (39%)
		C2H2 Zn finger	227..249	CDD:275368	12/21 (57%)
		C2H2 Zn finger	257..277	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..323		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4986
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960