DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hkb and KLF1

DIOPT Version :9

Sequence 1:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster
Sequence 2:NP_006554.1 Gene:KLF1 / 10661 HGNCID:6345 Length:362 Species:Homo sapiens


Alignment Length:356 Identity:89/356 - (25%)
Similarity:135/356 - (37%) Gaps:84/356 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTIN-LHP-PQTYSRLFRPWDTQRQAATSAAPRTVKQEPEAITIKTE----------------- 46
            :||:. |.| |.|.....:.|.::........|....:.|  :.:|:|                 
Human    11 ISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPP--LHVKSEDQPGEEEDDERGADATW 73

  Fly    47 ----LASSSFGHDCDGDFSSASSSASSSSNSSKSCYEEAL-----------------NHSSYTRT 90
                |.::..|.:..|...:.:.:.|.:|.:......|.|                 :||.:.|.
Human    74 DLDLLLTNFSGPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRP 138

  Fly    91 ST----------PLLDAAP---------HPVFSHPQSSPLDTHAAATASLAPPNQHAPF--LSAA 134
            :.          |.|..||         .||:..|.:.....:...|....|....||:  ||..
Human   139 ALRARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGY 203

  Fly   135 SDLYYA------------AAAAAAAAASTPTAVPGFGMDPFTMGL---MEQEYARVMAEDAQLK- 183
            ..:|.|            ....|...|::|:.:...|  |.|:|.   ...|...|:||.|..| 
Human   204 PAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLG--PGTVGTGLGGTAEDPGVIAETAPSKR 266

  Fly   184 -ALNSRKQRPKKFKC--PNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKR 245
             ..:..::|.....|  |.|..:::.:..||.|:|.||||:|:.|....||..|.|::|||||.|
Human   267 GRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYR 331

  Fly   246 IHTGLRPYPCSACGKKFGRRDHLKKHMKTHM 276
            .|||.||:.|..|.:.|.|.|||..|||.|:
Human   332 KHTGQRPFRCQLCPRAFSRSDHLALHMKRHL 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hkbNP_524221.1 COG5048 195..>261 CDD:227381 30/67 (45%)
zf-C2H2 195..217 CDD:278523 7/23 (30%)
C2H2 Zn finger 197..217 CDD:275368 7/21 (33%)
zf-H2C2_2 210..236 CDD:290200 13/25 (52%)
C2H2 Zn finger 225..247 CDD:275368 11/21 (52%)
zf-H2C2_2 239..264 CDD:290200 14/24 (58%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)
KLF1NP_006554.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..110 16/100 (16%)
EKLF_TAD1 22..>42 CDD:293437 2/19 (11%)
EKLF_TAD2 59..85 CDD:293438 1/25 (4%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 71..79 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..271 6/21 (29%)
zf-C2H2 279..303 CDD:278523 7/23 (30%)
COG5048 <281..>361 CDD:227381 38/79 (48%)
C2H2 Zn finger 284..303 CDD:275368 6/18 (33%)
zf-H2C2_2 295..322 CDD:290200 13/26 (50%)
C2H2 Zn finger 311..333 CDD:275368 11/21 (52%)
zf-H2C2_2 325..350 CDD:290200 14/24 (58%)
C2H2 Zn finger 341..361 CDD:275368 10/19 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 101 1.000 Inparanoid score I4986
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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