Protein Alignment hkb and KLF1

DIOPT Version :10

• Sequence 1: NP_524221.1
• Gene: hkb / 40549
• FlyBaseID: FBgn0261434
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_006554.1
• Gene: KLF1 / 10661
• HGNCID: 6345
• Length: 362
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 89/356 - (25%)
• Similarity: 135/356 - (37%)
• Gaps: 84/356 - (23%)

  Fly     1 MSTIN-LHP-PQTYSRLFRPWDTQRQAATSAAPRTVKQEPEAITIKTE----------------- 46
            :||:. |.| |.|.....:.|.::........|....:.|  :.:|:|
Human    11 ISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPP--LHVKSEDQPGEEEDDERGADATW 73

  Fly    47 ----LASSSFGHDCDGDFSSASSSASSSSNSSKSCYEEAL-----------------NHSSYTRT 90
                |.::..|.:..|...:.:.:.|.:|.:......|.|                 :||.:.|.
Human    74 DLDLLLTNFSGPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRP 138

  Fly    91 ST----------PLLDAAP---------HPVFSHPQSSPLDTHAAATASLAPPNQHAPF--LSAA 134
            :.          |.|..||         .||:..|.:.....:...|....|....||:  ||..
Human   139 ALRARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGY 203

  Fly   135 SDLYYA------------AAAAAAAAASTPTAVPGFGMDPFTMGL---MEQEYARVMAEDAQLK- 183
            ..:|.|            ....|...|::|:.:...|  |.|:|.   ...|...|:||.|..|
Human   204 PAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLG--PGTVGTGLGGTAEDPGVIAETAPSKR 266

  Fly   184 -ALNSRKQRPKKFKC--PNCDVAFSNNGQLKGHIRIHTGERPFKCDVNTCGKTFTRNEELTRHKR 245
             ..:..::|.....|  |.|..:::.:..||.|:|.||||:|:.|....||..|.|::|||||.|
Human   267 GRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYR 331

  Fly   246 IHTGLRPYPCSACGKKFGRRDHLKKHMKTHM 276
            .|||.||:.|..|.:.|.|.|||..|||.|:
Human   332 KHTGQRPFRCQLCPRAFSRSDHLALHMKRHL 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hkb	NP_524221.1	COG5048	195..>261	CDD:227381	30/67 (45%)
		C2H2 Zn finger	197..217	CDD:275368	7/21 (33%)
		C2H2 Zn finger	225..247	CDD:275368	11/21 (52%)
		zf-C2H2	253..275	CDD:395048	10/21 (48%)
		C2H2 Zn finger	255..275	CDD:275368	10/19 (53%)
KLF1	NP_006554.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..110		16/100 (16%)
		KLF1_N	10..279	CDD:409227	50/271 (18%)
		9aaTAD. /evidence=ECO:0000269|PubMed:31375868	71..79		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..271		6/21 (29%)
		COG5048	<281..>361	CDD:227381	38/79 (48%)
		C2H2 Zn finger	284..303	CDD:275368	6/18 (33%)
		C2H2 Zn finger	311..333	CDD:275368	11/21 (52%)
		C2H2 Zn finger	341..361	CDD:275368	10/19 (53%)