Protein Alignment Skp2 and FBXL18

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001308142.1
• Gene: FBXL18 / 80028
• HGNCID: 21874
• Length: 801
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 114/588 - (19%)
• Similarity: 197/588 - (33%)
• Gaps: 187/588 - (31%)

  Fly   100 VSRMAHQLQHTQRLSLG-STG-DITLDSPAVEDSLSMSRQ-----------------SAEKL--- 142
            :|:|...|||.:.|::. |.| |.:..|...:.:||..|:                 |.|||
Human   136 LSKMLSALQHLRSLAIDVSPGFDASQLSSECKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLY 200

  Fly   143 -QILAQAKRSSL--GSEGSGNSNSPS-KRLR---NPLAAVTCNNQIDGTASLNFQPSTSRLAQVR 200
             :||.:.:..::  |....|.||.|. :.||   ..||....|.::   ..|.....:.|..|..
Human   201 FEILDRTREGAILSGQLMVGQSNVPHYQNLRVFYARLAPGYINQEV---VRLYLAVLSDRTPQNL 262

  Fly   201 QAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFK----WLPKKTLLR 261
            .|                  |:...|...|...:..|..:.::..::||..:    ||...:||:
Human   263 HA------------------FLISVPGSFAESGATKNLLDSMARNVVLDALQLPKSWLNGSSLLQ 309

  Fly   262 MATVCR----RFNRCSRDETLWTRLDLGLRTIRPGAL-EQIVRRGV------------------- 302
            ......    .|:||               |:..|.| :|::..|.
Human   310 HMKFNNPFYFSFSRC---------------TLSGGHLIQQVINGGKDLRSLASLNLSGCVHCLSP 359

  Fly   303 -LVIRLAQTSIQEPAFAPYTEVFRT------RLQYLDLSMASITRSS-----LLTLLSHCRQLKK 355
             .::|.|:..|.       :.:..|      .|::|:||.|....|.     |..||:..|.|:.
Human   360 DSLLRKAEDDID-------SSILETLVASCCNLRHLNLSAAHHHSSEGLGRHLCQLLARLRHLRS 417

  Fly   356 ISLENIELDD--------------------------------------DICAE-------IAKN- 374
            :||....:.|                                      ..|.:       :.||
Human   418 LSLPVCSVADSAPRADRAPAQPAMHAVPRGFGKKVRVGVQSCPSPFSGQACPQPSSVFWSLLKNL 482

  Fly   375 ---EALEAVNLTMASGLTSN--SVRLMMESLTSLSSLNISWTDLSADAVTALVTHISPNLIRLNI 434
               |.||.:....:|.:..|  ::|..:...:...|:..|  :::|....|.:.|       |.:
Human   483 PFLEHLELIGSNFSSAMPRNEPAIRNSLPPCSRAQSVGDS--EVAAIGQLAFLRH-------LTL 538

  Fly   435 AGCRRVLFDSHVATLQKRCPQLLELDLSDCNSL-----TPTVITAIMKFKMLEYLSVSRCYLIPA 494
            |....||..|.:..:..:|.||..|.|::...:     .|.:...:...|.|..|.:.:.|....
Human   539 AQLPSVLTGSGLVNIGLQCQQLRSLSLANLGMMGKVVYMPALSDMLKHCKRLRDLRLEQPYFSAN 603

  Fly   495 TKFIE-LKSMPSLTYLDIF---GMLS-DTAMEVLEKQLPKMGINKFIHSSVSRPTVGTRRTSI-- 552
            .:|.: |...|||..|.:.   |.|. |..:..:.:.|..:..:.|...|::  |..:.:.|:
Human   604 AQFFQALSQCPSLQRLCLVSRSGTLQPDAVLAFMARCLQVVMCHLFTGESLA--TCKSLQQSLLR 666

  Fly   553 -WG 554
             ||
Human   667 RWG 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	9/49 (18%)
		leucine-rich repeat	302..327	CDD:275381	4/50 (8%)
		AMN1	309..480	CDD:187754	41/237 (17%)
		leucine-rich repeat	328..352	CDD:275381	9/28 (32%)
		leucine-rich repeat	353..376	CDD:275381	7/71 (10%)
		leucine-rich repeat	377..402	CDD:275381	5/26 (19%)
		leucine-rich repeat	403..428	CDD:275381	5/24 (21%)
		leucine-rich repeat	429..455	CDD:275381	6/25 (24%)
		leucine-rich repeat	456..480	CDD:275381	4/28 (14%)
		leucine-rich repeat	481..500	CDD:275381	4/19 (21%)
		leucine-rich repeat	506..529	CDD:275381	6/26 (23%)
FBXL18	NP_001308142.1	F-box_FBXL18	28..71	CDD:438900
		FBXL18_LRR	85..678	CDD:466163	114/588 (19%)
		leucine-rich repeat	345..384	CDD:275381	4/45 (9%)
		leucine-rich repeat	385..414	CDD:275381	9/28 (32%)
		leucine-rich repeat	415..484	CDD:275381	7/68 (10%)
		leucine-rich repeat	451..476	CDD:275381	1/24 (4%)
		leucine-rich repeat	485..532	CDD:275381	9/48 (19%)
		leucine-rich repeat	533..559	CDD:275381	7/32 (22%)
		leucine-rich repeat	560..589	CDD:275381	4/28 (14%)
		leucine-rich repeat	590..615	CDD:275381	5/24 (21%)
		leucine-rich repeat	616..640	CDD:275381	5/23 (22%)