DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl17

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_001335097.5	Gene:	fbxl17 / 795023	ZFINID:	ZDB-GENE-111013-3	Length:	409	Species:	Danio rerio

Alignment Length:	235	Identity:	54/235 - (22%)
Similarity:	92/235 - (39%)	Gaps:	51/235 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SSLGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRLAQVRQAKK-PSTTNITTRI 214
            ||..|..|....:.:.|..:|..|.||:             |:|...|...::: .||.|..|
Zfish   169 SSSSSSASEEDGATAGRHSDPGGATTCS-------------SSSCCCQTEASEEIKSTENTDT-- 218

  Fly   215 VAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLP-KKTLLRMATVCRRFNRCSRDETL 278
                           :|||       :|...|||.:|..|. |:..|..:.||:.:.....|...
Zfish   219 ---------------SHIN-------QLPSSILLKVFSHLSVKERCLAASLVCKYWRDLCLDFQF 261

  Fly   279 WTRLDL-GLRTIRPGALEQIV--RRGVLVIRLAQ-TSIQEPAFAPYTEVFRTRLQYLDLSMASIT 339
            |.::|| ||:.::...|.:|.  |:.|..|.::. .::|:.............::|.......::
Zfish   262 WKQIDLSGLQQVKDDLLVKIASRRQNVTEINISDCRNVQDHGVCALASNCAGLIKYTAYRCKQLS 326

  Fly   340 RSSLLTLLSHCRQLKKISLEN--------IELDDDICAEI 371
            ..||.|:..||..|:|:.:.|        ::|..|.|.|:
Zfish   327 DVSLSTVAIHCPLLQKVHVGNQDKLTDHALKLLGDHCKEL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	12/45 (27%)
		leucine-rich repeat	302..327	CDD:275381	3/25 (12%)
		AMN1	309..480	CDD:187754	14/72 (19%)
		leucine-rich repeat	328..352	CDD:275381	6/23 (26%)
		leucine-rich repeat	353..376	CDD:275381	7/27 (26%)
		leucine-rich repeat	377..402	CDD:275381
		leucine-rich repeat	403..428	CDD:275381
		leucine-rich repeat	429..455	CDD:275381
		leucine-rich repeat	456..480	CDD:275381
		leucine-rich repeat	481..500	CDD:275381
		leucine-rich repeat	506..529	CDD:275381
fbxl17	XP_001335097.5	F-box-like	221..268	CDD:289689	15/53 (28%)
		AMN1	257..>397	CDD:187754	25/110 (23%)
		leucine-rich repeat	262..287	CDD:275381	8/24 (33%)
		leucine-rich repeat	288..313	CDD:275381	3/24 (13%)
		leucine-rich repeat	314..339	CDD:275381	6/24 (25%)
		leucine-rich repeat	340..365	CDD:275381	6/24 (25%)
		leucine-rich repeat	366..391	CDD:275381	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940