DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and FBXL15

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:XP_005270206.1 Gene:FBXL15 / 79176 HGNCID:28155 Length:387 Species:Homo sapiens


Alignment Length:258 Identity:66/258 - (25%)
Similarity:107/258 - (41%) Gaps:39/258 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   244 DEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDL-GLRTIRPGALEQIVRRGVL--VI 305
            |.:|..:...:|.:.|||:..|.|.|...       .:|.| |||......:...:.|..|  ::
Human   113 DVLLPHVLNRVPLRQLLRLQRVSRAFRSL-------V
QLHLAGLRRFDAAQVGPQIPRAALARLL 170

  Fly   306 RLAQTSIQEPAFAPYTE---------VFRTRLQYLDLSM---ASITRSSLLTLLSHCRQLKKISL 358
            |.|: .:||.|.||..|         |.....|...:::   ..::|.:|..|...|.:|:::||
Human   171 RDAE-GLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSL 234

  Fly   359 ENIELDD--------DICAEIAKNEALEAVNLTMASGLTSNS-VRLMMESLTSLSSLNISWTDLS 414
            .:.:..|        |.|      .|||.::||....|...: |.|.......|.||:::.....
Human   235 AHCDWVDGLALRGLADRC------PALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANV 293

  Fly   415 ADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMK 477
            .||....:....|.|..|::.||.||..|. |.||.:.||.|..|.:..|:.:..:.::.:.|
Human   294 GDAAVQELARNCPELHHLDLTGCLRVGSDG-VRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 10/39 (26%)
leucine-rich repeat 302..327 CDD:275381 10/35 (29%)
AMN1 309..480 CDD:187754 48/190 (25%)
leucine-rich repeat 328..352 CDD:275381 5/26 (19%)
leucine-rich repeat 353..376 CDD:275381 6/30 (20%)
leucine-rich repeat 377..402 CDD:275381 7/25 (28%)
leucine-rich repeat 403..428 CDD:275381 5/24 (21%)
leucine-rich repeat 429..455 CDD:275381 11/25 (44%)
leucine-rich repeat 456..480 CDD:275381 4/22 (18%)
leucine-rich repeat 481..500 CDD:275381
leucine-rich repeat 506..529 CDD:275381
FBXL15XP_005270206.1 F-box 105..>142 CDD:279040 9/35 (26%)
leucine-rich repeat 149..175 CDD:275381 6/26 (23%)
leucine-rich repeat 176..202 CDD:275381 7/25 (28%)
leucine-rich repeat 203..228 CDD:275381 4/24 (17%)
AMN1 <226..>353 CDD:187754 36/133 (27%)
leucine-rich repeat 229..254 CDD:275381 6/30 (20%)
leucine-rich repeat 255..281 CDD:275381 7/25 (28%)
leucine-rich repeat 282..307 CDD:275381 5/24 (21%)
leucine-rich repeat 308..332 CDD:275381 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153061
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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