DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and Fbxl22

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_780415.1	Gene:	Fbxl22 / 74165	MGIID:	1921415	Length:	236	Species:	Mus musculus

Alignment Length:	277	Identity:	56/277 - (20%)
Similarity:	91/277 - (32%)	Gaps:	92/277 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGV 302
            :..:|:.|.||.:|.:|.|.:...::..|.:......|.|||..|..
Mouse     2 HITQLNRECLLCLFSFLDKDSRRSLSRTCSQLRDVFEDPTLWPLLHF------------------ 48

  Fly   303 LVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIE----- 362
                   .|:.|                  |...:...|..|..||.|....::.:.:||
Mouse    49 -------HSLAE------------------LKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKS 88

  Fly   363 -LDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHIS 426
             |...||::                          .|||.:...|.              |.:..
Mouse    89 ALQRSICSQ--------------------------HESLVNDFLLQ--------------VCNRC 113

  Fly   427 PNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKF-KMLEYLSVSRCY 490
            |||..:.::||..|. |..:|.|...||:|..|.|.:|..:|...:.|:... :.|:.|.|..|.
Mouse   114 PNLTSVTLSGCGHVT-DDCLARLLLSCPRLRTLRLENCARVTNRTLAAVAAHGRALQTLHVDFCR 177

  Fly   491 LIPATKFIELK-SMPSL 506
            .:.|...:.|: :.|:|
Mouse   178 NVSAAGLLRLRAACPNL 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	13/44 (30%)
		leucine-rich repeat	302..327	CDD:275381	2/24 (8%)
		AMN1	309..480	CDD:187754	35/177 (20%)
		leucine-rich repeat	328..352	CDD:275381	6/23 (26%)
		leucine-rich repeat	353..376	CDD:275381	5/28 (18%)
		leucine-rich repeat	377..402	CDD:275381	3/24 (13%)
		leucine-rich repeat	403..428	CDD:275381	2/24 (8%)
		leucine-rich repeat	429..455	CDD:275381	8/25 (32%)
		leucine-rich repeat	456..480	CDD:275381	6/24 (25%)
		leucine-rich repeat	481..500	CDD:275381	5/18 (28%)
		leucine-rich repeat	506..529	CDD:275381	1/1 (100%)
Fbxl22	NP_780415.1	F-box-like	3..43	CDD:403981	10/39 (26%)
		LRR 1	15..40		4/24 (17%)
		LRR 2	43..72		9/71 (13%)
		AMN1	45..>200	CDD:187754	44/234 (19%)
		LRR 3	98..123		8/38 (21%)
		leucine-rich repeat	116..141	CDD:275381	8/25 (32%)
		LRR 4	124..149		10/25 (40%)
		leucine-rich repeat	142..167	CDD:275381	6/24 (25%)
		LRR 5	150..175		6/24 (25%)
		leucine-rich repeat	168..193	CDD:275381	6/24 (25%)
		LRR 6	176..201		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030