Protein Alignment Skp2 and Fbxl22

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_780415.1
• Gene: Fbxl22 / 74165
• MGIID: 1921415
• Length: 236
• Species: Mus musculus
• Alignment Length: 277
• Identity: 56/277 - (20%)
• Similarity: 91/277 - (32%)
• Gaps: 92/277 - (33%)

  Fly   238 YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGV 302
            :..:|:.|.||.:|.:|.|.:...::..|.:......|.|||..|..
Mouse     2 HITQLNRECLLCLFSFLDKDSRRSLSRTCSQLRDVFEDPTLWPLLHF------------------ 48

  Fly   303 LVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIE----- 362
                   .|:.|                  |...:...|..|..||.|....::.:.:||
Mouse    49 -------HSLAE------------------LKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKS 88

  Fly   363 -LDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHIS 426
             |...||::                          .|||.:...|.              |.:..
Mouse    89 ALQRSICSQ--------------------------HESLVNDFLLQ--------------VCNRC 113

  Fly   427 PNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKF-KMLEYLSVSRCY 490
            |||..:.::||..|. |..:|.|...||:|..|.|.:|..:|...:.|:... :.|:.|.|..|.
Mouse   114 PNLTSVTLSGCGHVT-DDCLARLLLSCPRLRTLRLENCARVTNRTLAAVAAHGRALQTLHVDFCR 177

  Fly   491 LIPATKFIELK-SMPSL 506
            .:.|...:.|: :.|:|
Mouse   178 NVSAAGLLRLRAACPNL 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	12/41 (29%)
		leucine-rich repeat	302..327	CDD:275381	2/24 (8%)
		AMN1	309..480	CDD:187754	35/177 (20%)
		leucine-rich repeat	328..352	CDD:275381	6/23 (26%)
		leucine-rich repeat	353..376	CDD:275381	5/28 (18%)
		leucine-rich repeat	377..402	CDD:275381	3/24 (13%)
		leucine-rich repeat	403..428	CDD:275381	2/24 (8%)
		leucine-rich repeat	429..455	CDD:275381	8/25 (32%)
		leucine-rich repeat	456..480	CDD:275381	6/24 (25%)
		leucine-rich repeat	481..500	CDD:275381	5/18 (28%)
		leucine-rich repeat	506..529	CDD:275381	1/1 (100%)
Fbxl22	NP_780415.1	F-box_FBXL22	3..45	CDD:438901	12/41 (29%)
		LRR 1	15..40		4/24 (17%)
		LRR 2	43..72		9/71 (13%)
		AMN1	45..>200	CDD:187754	44/234 (19%)
		LRR 3	98..123		8/38 (21%)
		leucine-rich repeat	116..141	CDD:275381	8/25 (32%)
		LRR 4	124..149		10/25 (40%)
		leucine-rich repeat	142..167	CDD:275381	6/24 (25%)
		LRR 5	150..175		6/24 (25%)
		leucine-rich repeat	168..193	CDD:275381	6/24 (25%)
		LRR 6	176..201		5/19 (26%)