DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and Fbxl20

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	443	Identity:	98/443 - (22%)
Similarity:	165/443 - (37%)	Gaps:	139/443 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 FVFRTPAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDL- 284
            |.|:....|....:.||  ::|..|:||.||.:|...||.|.|.|.|.:|..:.|.:.|.|:||
Mouse    11 FGFKATMFSNSDEAVIN--KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLF 73

  Fly   285 -GLRTIRPGALEQIVRR-GVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLL 347
             ..|.|....:|.|.:| |..:.:|:..                       ....:..::|.|..
Mouse    74 DFQRDIEGRVVENISKRCGGFLRKLSLR-----------------------GCLGVGDNALRTFA 115

  Fly   348 SHCRQLKKISLEN-IELDDDICAEIAK-NEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISW 410
            .:||.::.:||.. .:..|..|..::| ...|..::|...:.:|:.|::.:.|....|..|||||
Mouse   116 QNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISW 180

  Fly   411 TD-LSADAVTALV--------------THIS-----------PNLIRLNI--------------- 434
            .| ::.|.:.|||              |.:.           |.|:.||:
Mouse   181 CDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC 245

  Fly   435 -----------AGCRRV-------------------------LFDSHVATLQKRCPQLLELDLSD 463
                       :||..:                         |.|....||.:.|.:|.::||.:
Mouse   246 RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEE 310

  Fly   464 CNSLT-PTVITAIMKFKMLEYLSVSRCYLI---------------PATKFIELKSMPSLTYLDIF 512
            |..:| .|:|...:....|:.||:|.|.||               ...:.|||.:.|.:|...:.
Mouse   311 CVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLE 375

  Fly   513 GMLSDTAMEVLE----KQLPKMGINKF--------IHSSVS----RPTVGTRR 549
            .:.|..::|.:|    :|:.:.||.:.        :|:..:    .|:||..|
Mouse   376 HLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	17/44 (39%)
		leucine-rich repeat	302..327	CDD:275381	1/24 (4%)
		AMN1	309..480	CDD:187754	44/250 (18%)
		leucine-rich repeat	328..352	CDD:275381	3/23 (13%)
		leucine-rich repeat	353..376	CDD:275381	5/24 (21%)
		leucine-rich repeat	377..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	403..428	CDD:275381	12/50 (24%)
		leucine-rich repeat	429..455	CDD:275381	10/76 (13%)
		leucine-rich repeat	456..480	CDD:275381	7/24 (29%)
		leucine-rich repeat	481..500	CDD:275381	8/33 (24%)
		leucine-rich repeat	506..529	CDD:275381	5/26 (19%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	17/40 (43%)
		leucine-rich repeat	67..94	CDD:275381	10/26 (38%)
		AMN1	95..291	CDD:187754	34/218 (16%)
		leucine-rich repeat	95..114	CDD:275381	2/41 (5%)
		leucine-rich repeat	121..146	CDD:275381	5/24 (21%)
		leucine-rich repeat	147..172	CDD:275381	5/24 (21%)
		leucine-rich repeat	173..198	CDD:275381	11/24 (46%)
		leucine-rich repeat	199..224	CDD:275381	1/24 (4%)
		AMN1	222..396	CDD:187754	34/173 (20%)
		leucine-rich repeat	225..250	CDD:275381	3/24 (13%)
		leucine-rich repeat	251..276	CDD:275381	2/24 (8%)
		leucine-rich repeat	277..302	CDD:275381	5/24 (21%)
		leucine-rich repeat	303..328	CDD:275381	7/24 (29%)
		leucine-rich repeat	329..357	CDD:275381	7/27 (26%)
		leucine-rich repeat	358..382	CDD:275381	6/23 (26%)
		leucine-rich repeat	383..408	CDD:275381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840