DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl2

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_848739.1 Gene:Fbxl2 / 72179 MGIID:1919429 Length:423 Species:Mus musculus


Alignment Length:361 Identity:84/361 - (23%)
Similarity:153/361 - (42%) Gaps:76/361 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   240 ERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDL-GLRT-IRPGALEQIVRR-G 301
            ::|..|:||.||.:|...||.|.|.:.:.:|..:.|.:.|.|:|| ..:| :....:|.|.:| |
Mouse    13 KKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQTDVEGRVVENISKRCG 77

  Fly   302 VLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLEN-IELDD 365
            ..:.:|:..                       ....:..|||.|...:||.::.::|.. .::.|
Mouse    78 GFLRKLSLR-----------------------GCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITD 119

  Fly   366 DICAEIAK-NEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTD-LSADAVTALV------ 422
            ..|..::: ...|:.::||....:|::|::.:.|...:|..||:||.| ::.:.:.|||      
Mouse   120 STCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGL 184

  Fly   423 ----------------THISPN---LIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLT 468
                            .||..:   |:.||:..|.|:. |..|..:.:.|.:|..|.||.|::||
Mouse   185 KALLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRIT-DDGVVQICRGCHRLQALCLSGCSNLT 248

  Fly   469 PTVITAI-MKFKMLEYLSVSRC-------YLIPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEK 525
            ...:||: :....|:.|..:||       :.:.|....||:.|.    |:...:::|:.:..|..
Mouse   249 DASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMD----LEECVLITDSTLVQLSI 309

  Fly   526 QLPKMGINKFIHSS---------VSRPTVGTRRTSI 552
            ..||:......|..         :|..|.|..|..:
Mouse   310 HCPKLQALSLSHCELITDEGILHLSSSTCGHERLRV 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 15/43 (35%)
leucine-rich repeat 302..327 CDD:275381 1/24 (4%)
AMN1 309..480 CDD:187754 43/199 (22%)
leucine-rich repeat 328..352 CDD:275381 5/23 (22%)
leucine-rich repeat 353..376 CDD:275381 3/24 (13%)
leucine-rich repeat 377..402 CDD:275381 6/24 (25%)
leucine-rich repeat 403..428 CDD:275381 11/47 (23%)
leucine-rich repeat 429..455 CDD:275381 8/25 (32%)
leucine-rich repeat 456..480 CDD:275381 9/24 (38%)
leucine-rich repeat 481..500 CDD:275381 5/25 (20%)
leucine-rich repeat 506..529 CDD:275381 3/22 (14%)
Fbxl2NP_848739.1 F-box-like 15..57 CDD:289689 15/41 (37%)
leucine-rich repeat 52..79 CDD:275381 9/26 (35%)
LRR 1 61..87 6/48 (13%)
AMN1 <76..223 CDD:187754 33/170 (19%)
leucine-rich repeat 80..99 CDD:275381 4/41 (10%)
Interaction with Calmodulin. /evidence=ECO:0000269|PubMed:21343341 80..90 1/32 (3%)
LRR 2 88..113 7/24 (29%)
leucine-rich repeat 106..131 CDD:275381 3/24 (13%)
LRR 3 114..139 4/24 (17%)
leucine-rich repeat 132..157 CDD:275381 6/24 (25%)
LRR 4 140..165 6/24 (25%)
leucine-rich repeat 158..183 CDD:275381 9/24 (38%)
LRR 5 166..191 4/24 (17%)
AMN1 168..367 CDD:187754 40/183 (22%)
leucine-rich repeat 184..209 CDD:275381 2/24 (8%)
LRR 6 192..217 5/24 (21%)
leucine-rich repeat 210..235 CDD:275381 8/25 (32%)
LRR 7 218..243 8/25 (32%)
leucine-rich repeat 236..261 CDD:275381 9/24 (38%)
LRR 8 244..269 7/24 (29%)
leucine-rich repeat 262..287 CDD:275381 5/24 (21%)
LRR 9 270..295 6/28 (21%)
leucine-rich repeat 288..313 CDD:275381 5/28 (18%)
LRR 10 296..321 4/24 (17%)
leucine-rich repeat 314..336 CDD:275381 2/21 (10%)
LRR 11 322..350 4/24 (17%)
leucine-rich repeat 343..362 CDD:275381 0/3 (0%)
LRR 12 351..375
LRR 13 376..401
CAAX motif 420..423
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167843143
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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