Protein Alignment Skp2 and FBXL17

DIOPT Version :9

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_005272105.1
• Gene: FBXL17 / 64839
• HGNCID: 13615
• Length: 712
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 136/635 - (21%)
• Similarity: 206/635 - (32%)
• Gaps: 190/635 - (29%)

  Fly     8 GSENMENLCPVTRKRSTNKNHVSVVGALVSTTKSSHYEHPSSPSALTFEALEEMGIGMLDSEESS 72
            |.|....|.|..|.           ||..:.:.|.|.       |..:.||..............
Human    75 GPEEEPPLSPPPRD-----------GAYAAASSSQHL-------ARRYAALAAEDCAAAARRFLL 121

  Fly    73 SSALSAIALAVSATSDDNSNETTPCASVSRMAHQLQHTQRLSLGSTGDIT-LDSPAVEDSLSMSR 136
            |||.:|.|.|.||:|..:..:....|:.:...   |..:.|.|.|.|.:. |..||.........
Human   122 SSAAAAAAAAASASSPASCCKELGLAAAAAWE---QQGRSLFLASLGPVRFLGPPAAVQLFRGPT 183

  Fly   137 QSAEKL----QILAQAKRSSL--------------------------GSEGSGNS---------- 161
            .|..:|    :::.:.|.:.:                          |..|.|.|
Human   184 PSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCC 248

  Fly   162 ---NSPSKRLRNPLAAVTCNN----------QIDGTASLNFQ-----------PSTSRLAQVRQA 202
               ..|.:.|..|.::.|...          :..|||.|:.|           .|........:.
Human   249 QAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHRE 313

  Fly   203 KKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLP-KKTLLRMATVC 266
            ..|.|.:|                             .:|...|||.||..|. .:..|..:.||
Human   314 PPPETPDI-----------------------------NQLPPSILLKIFSNLSLDERCLSASLVC 349

  Fly   267 RRFNRCSRDETLWTRLDLGLR-TIRPGALEQIVRRGVLVIRLAQTSIQE-------------PAF 317
            :.:.....|...|.:|||..| .:....||:|..|...:|.:..:..:.             |..
Human   350 KYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGL 414

  Fly   318 APYTEVFRTRLQYLDLSMASI------------------TRSSLLTLLSHCRQLKKISL-ENIEL 363
            ..|| .:|.: |..|.|:.::                  |...|..|.|.||:||.|.. :..::
Human   415 LRYT-AYRCK-QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKI 477

  Fly   364 DDDICAEIAKNEALEAVNLTMASG--LTSNSVRLMME-------------SLTS----------- 402
            .|:....|||. .|:...:.|...  :|..||:...|             |:||
Human   478 SDEGMIVIAKG-CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRN 541

  Fly   403 LSSLNISW-TDLSADAVTALVTHISPNLIRLNIAGCRR-VLFDSHVATLQKRCPQLLELDLSDCN 465
            ||||::.. |:|..:.|..:|.... ||..||:  |.. ::.|..|..:.|....|.||.|..|
Human   542 LSSLDLRHITELDNETVMEIVKRCK-NLSSLNL--CLNWIINDRCVEVIAKEGQNLKELYLVSC- 602

  Fly   466 SLTPTVITAIMKFKM-LEYLSVSRCYLIP---ATKFIELKSMPSLTYLDI 511
            .:|...:.||.::.| :|.:.|..|..|.   ||  :..:|..||.||.:
Human   603 KITDYALIAIGRYSMTIETVDVGWCKEITDQGAT--LIAQSSKSLRYLGL 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	13/45 (29%)
		leucine-rich repeat	302..327	CDD:275381	5/37 (14%)
		AMN1	309..480	CDD:187754	53/230 (23%)
		leucine-rich repeat	328..352	CDD:275381	8/41 (20%)
		leucine-rich repeat	353..376	CDD:275381	7/23 (30%)
		leucine-rich repeat	377..402	CDD:275381	7/39 (18%)
		leucine-rich repeat	403..428	CDD:275381	8/25 (32%)
		leucine-rich repeat	429..455	CDD:275381	7/26 (27%)
		leucine-rich repeat	456..480	CDD:275381	8/23 (35%)
		leucine-rich repeat	481..500	CDD:275381	6/21 (29%)
		leucine-rich repeat	506..529	CDD:275381	3/6 (50%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	15/75 (20%)
		leucine-rich repeat	362..387	CDD:275381	9/24 (38%)
		leucine-rich repeat	388..413	CDD:275381	1/24 (4%)
		AMN1	411..573	CDD:187754	40/165 (24%)
		leucine-rich repeat	414..439	CDD:275381	6/26 (23%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
		leucine-rich repeat	466..491	CDD:275381	7/25 (28%)
		leucine-rich repeat	492..517	CDD:275381	5/24 (21%)
		leucine-rich repeat	518..541	CDD:275381	3/22 (14%)
		leucine-rich repeat	542..567	CDD:275381	8/25 (32%)
		AMN1	547..>652	CDD:187754	32/110 (29%)
		leucine-rich repeat	568..593	CDD:275381	7/26 (27%)
		leucine-rich repeat	594..615	CDD:275381	8/21 (38%)
		leucine-rich repeat	619..641	CDD:275381	6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940