DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl7

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001073511.1	Gene:	fbxl7 / 569430	ZFINID:	ZDB-GENE-061215-122	Length:	489	Species:	Danio rerio

Alignment Length:	492	Identity:	115/492 - (23%)
Similarity:	180/492 - (36%)	Gaps:	129/492 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SEESSSSALSAIALAVSATSDDNSNETTPCASVSRMAHQLQHTQRLSLGSTGDITLDSPAVEDS- 131
            ||...||::|:   .:|:::|..|.:....|:.|                           |||
Zfish    11 SEGKGSSSISS---DLSSSTDQTSTKAPKNAATS---------------------------EDSD 45

  Fly   132 LSMSRQSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRL 196
            |||...|.....::...:.||....||..|:|            |...:   |.::...|.||..
Zfish    46 LSMRTVSTPSPALILPPRSSSAVLNGSSTSSS------------TFGTE---TIAMVHMPPTSLT 95

  Fly   197 AQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLR 261
            ...|..::|                   .....|.:       :.|.|...|.||..||...|.|
Zfish    96 HPQRCLRQP-------------------RDQQGAPV-------DILPDHAFLQIFTHLPTNQLCR 134

  Fly   262 MATVCRRFNRCSRDETLWTRLDLGLRTIR-PGALEQIVRR-GVLVIRLAQTSIQEPAFAPYTEVF 324
            .|.||||:...:.|..||       |||| .|.:..:.|. .||..||.|.:         ..|.
Zfish   135 CARVCRRWYNLAWDPRLW-------RTIRLTGDVLHVDRALRVLTRRLCQDT---------PNVC 183

  Fly   325 RTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEA----------LEA 379
            .|....:......:|...|.|:...|.:|:::.:..       |..:: |||          ||.
Zfish   184 LTVETVMVSGCRRLTDRGLYTVAQSCPELRRLEVAG-------CYNVS-NEAVFEVVSRCPNLEH 240

  Fly   380 VNLTMASGLTSNSVRLMMESLTSLSSLN--------ISWTD---LSADAVTALVTHISPNLIRLN 433
            ::::..|.:|  .:.|..:....||.|:        :..||   |..:.:..:..|.: .|..|.
Zfish   241 LDVSGCSKVT--CISLTRDVSVKLSPLHGQQISIRFLDMTDCFALEDEGLHTIAAHCT-QLTHLY 302

  Fly   434 IAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFK-MLEYLSVSRCYLIP--AT 495
            :..|.| |.|..:..|...||.:.||.:|||..::...:..|.|.: .|.|||::.|..|.  ..
Zfish   303 LRRCVR-LTDEGLRFLVIYCPGVRELSVSDCRFISDFGLREIAKLEGRLRYLSIAHCSRITDVGV 366

  Fly   496 KFIELKSMPSLTYLDIFGM--LSDTAMEVLEKQLPKM 530
            ::: .|....|.||:..|.  |:|..:|.|.|...|:
Zfish   367 RYV-AKYCSRLRYLNARGCEGLTDHGIEHLAKSCLKL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	17/44 (39%)
		leucine-rich repeat	302..327	CDD:275381	6/24 (25%)
		AMN1	309..480	CDD:187754	40/192 (21%)
		leucine-rich repeat	328..352	CDD:275381	4/23 (17%)
		leucine-rich repeat	353..376	CDD:275381	3/22 (14%)
		leucine-rich repeat	377..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	403..428	CDD:275381	7/35 (20%)
		leucine-rich repeat	429..455	CDD:275381	8/25 (32%)
		leucine-rich repeat	456..480	CDD:275381	7/24 (29%)
		leucine-rich repeat	481..500	CDD:275381	6/20 (30%)
		leucine-rich repeat	506..529	CDD:275381	9/24 (38%)
fbxl7	NP_001073511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		21/94 (22%)
		F-box-like	112..158	CDD:289689	21/59 (36%)
		leucine-rich repeat	127..151	CDD:275381	10/23 (43%)
		leucine-rich repeat	152..185	CDD:275381	13/48 (27%)
		LRR 1	168..193		7/33 (21%)
		AMN1	<183..364	CDD:187754	44/192 (23%)
		leucine-rich repeat	186..211	CDD:275381	4/24 (17%)
		LRR 2	194..219		5/24 (21%)
		leucine-rich repeat	212..233	CDD:275381	5/28 (18%)
		LRR 3	220..245		6/25 (24%)
		leucine-rich repeat	238..271	CDD:275381	8/34 (24%)
		LRR 4	251..279		4/27 (15%)
		leucine-rich repeat	272..297	CDD:275381	4/25 (16%)
		LRR 5	280..305		4/25 (16%)
		AMN1	295..463	CDD:187754	33/111 (30%)
		leucine-rich repeat	298..323	CDD:275381	8/25 (32%)
		LRR 6	306..331		9/25 (36%)
		leucine-rich repeat	324..349	CDD:275381	7/24 (29%)
		LRR 7	332..357		7/24 (29%)
		leucine-rich repeat	350..375	CDD:275381	7/25 (28%)
		LRR 8	358..383		6/25 (24%)
		leucine-rich repeat	376..401	CDD:275381	9/24 (38%)
		LRR 9	384..409		6/19 (32%)
		leucine-rich repeat	402..427	CDD:275381	0/1 (0%)
		LRR 10	410..435
		leucine-rich repeat	428..451	CDD:275381
		LRR 11	436..461
		leucine-rich repeat	454..478	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840