DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl3l

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_693270.2	Gene:	fbxl3l / 564855	ZFINID:	ZDB-GENE-130530-598	Length:	448	Species:	Danio rerio

Alignment Length:	368	Identity:	77/368 - (20%)
Similarity:	140/368 - (38%)	Gaps:	103/368 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 NFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDE------- 245
            :|.||..|..:.|     |||.:                    ::.:|...|:..::|
Zfish    22 SFTPSEGRNKRHR-----STTPV--------------------YVQTGSTNFQNATEETWGNLPH 61

  Fly   246 -ILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLG--------LRTIRPGALEQIVRRG 301
             ::|.||::|......|.::||||:|.......||.|.:..        ||:..|..::||::|.
Zfish    62 HVVLHIFQYLSLVDRARASSVCRRWNEVFHIPDLWRRFEFELNQPATSYLRSTHPDLIQQIIKRH 126

  Fly   302 VLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRS-----SLLTLLSHCRQLKKISLENI 361
                  ||                 .|||:...:.|.|.|     ::|:.|.:| .:|.:.|
Zfish   127 ------AQ-----------------HLQYVSFKVDSCTESAEAACNILSQLVNC-TIKTLGL--- 164

  Fly   362 ELDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHIS 426
                   ...|:...::.......|.||     ::..:..||||:.|..|.:...::..||.:.|
Zfish   165 -------ISTARPSFMDVSQSHFVSALT-----VVFVNSKSLSSIKIDDTPVDDPSLKVLVANNS 217

  Fly   427 PNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIM--KFKMLEYLSVSRC 489
            ..|..|.::.|..| ..:.:..:..:|..|.||.| :.:.|:..::.|:.  |...||:|.:.
Zfish   218 DTLKLLKMSSCPHV-SPAGILCVADQCHGLRELAL-NYHLLSDELLLALSSEKHVHLEHLRID-- 278

  Fly   490 YLIPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMGI 532
                     .:...|..|.   |..:..::.:.|.:..|::.|
Zfish   279 ---------VVSENPGQTQ---FHTIKKSSWDALIRHSPQVNI 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	15/52 (29%)
		leucine-rich repeat	302..327	CDD:275381	2/24 (8%)
		AMN1	309..480	CDD:187754	37/177 (21%)
		leucine-rich repeat	328..352	CDD:275381	9/28 (32%)
		leucine-rich repeat	353..376	CDD:275381	3/22 (14%)
		leucine-rich repeat	377..402	CDD:275381	3/24 (13%)
		leucine-rich repeat	403..428	CDD:275381	8/24 (33%)
		leucine-rich repeat	429..455	CDD:275381	5/25 (20%)
		leucine-rich repeat	456..480	CDD:275381	7/25 (28%)
		leucine-rich repeat	481..500	CDD:275381	3/18 (17%)
		leucine-rich repeat	506..529	CDD:275381	3/22 (14%)
fbxl3l	XP_693270.2	F-box-like	56..99	CDD:289689	12/42 (29%)
		leucine-rich repeat	194..218	CDD:275381	7/23 (30%)
		leucine-rich repeat	220..245	CDD:275381	5/25 (20%)
		leucine-rich repeat	246..271	CDD:275381	7/25 (28%)
		leucine-rich repeat	272..306	CDD:275381	7/47 (15%)
		leucine-rich repeat	307..353	CDD:275381	1/3 (33%)
		AMN1	<347..>412	CDD:187754
		leucine-rich repeat	354..380	CDD:275381
		leucine-rich repeat	381..403	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940