Protein Alignment Skp2 and skp2

DIOPT Version :9

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_005161246.1
• Gene: skp2 / 563708
• ZFINID: ZDB-GENE-030219-158
• Length: 427
• Species: Danio rerio
• Alignment Length: 399
• Identity: 122/399 - (30%)
• Similarity: 206/399 - (51%)
• Gaps: 30/399 - (7%)

  Fly   186 SLNFQPSTSRLAQVRQAKKPS------TTNITTRIVAADS-------------------FFVFRT 225
            |.|.:.|..|..:.:..|:||      |.|....::...|                   |.:.|.
Zfish    28 SENLEGSLCRSQRTKWKKRPSCSSGLDTENTPNELIQQWSPPHKKALTTAKGKENEENLFVLARR 92

  Fly   226 PAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIR 290
            |......::.: .::.|.||:||.||..|..:.|||.:.||:|::|.:.||:||..:||..:...
Zfish    93 PRKRRESSANL-CWDSLPDELLLGIFSRLSLQDLLRTSRVCKRWHRLAFDESLWHSVDLVGKAQL 156

  Fly   291 PGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKK 355
            ...|.|::..|||.:|...|.|.:|:|.....:   |:|:||.|..::..|.|..:||.|:.|:.
Zfish   157 DAELGQVLSAGVLRLRCPHTCIGQPSFKSTPSL---RVQHLDFSNCTVETSVLEDVLSRCKHLQN 218

  Fly   356 ISLENIELDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTA 420
            :|||.:.|.|:|...:|:|..:..:||...||.:..|:..|:.:.|.:..:|:||.|.|...:.|
Zfish   219 LSLEGLVLSDNIIYSLAQNPEIIRLNLCGCSGFSPESLTEMLTACTRIEEMNVSWCDFSNLHIQA 283

  Fly   421 LVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFKMLEYLS 485
            :.::|..::.:|||:|.|:.|....|..:.||||.:.:|||||...:|......:.:...|.:|.
Zfish   284 IASNIPSSVSQLNISGYRQNLTMEDVKAIVKRCPNITDLDLSDSVLVTTDSFPVLQQLSSLRHLG 348

  Fly   486 VSRCYLIPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMGINKFIHSSVSRPTVGTRR- 549
            :||||.|.....|:.:...:|..|::||::.|:.:.:|.|.||.:.||....|:|:|||..:|:
Zfish   349 LSRCYQIHPASLIDFEKFLNLQTLEVFGLIQDSYLPILCKSLPHIQINTQPFSTVARPTSSSRKD 413

  Fly   550 TSIWGLRTR 558
            .::||:..|
Zfish   414 RTLWGMHCR 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	19/44 (43%)
		leucine-rich repeat	302..327	CDD:275381	7/24 (29%)
		AMN1	309..480	CDD:187754	54/170 (32%)
		leucine-rich repeat	328..352	CDD:275381	9/23 (39%)
		leucine-rich repeat	353..376	CDD:275381	9/22 (41%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		leucine-rich repeat	403..428	CDD:275381	7/24 (29%)
		leucine-rich repeat	429..455	CDD:275381	10/25 (40%)
		leucine-rich repeat	456..480	CDD:275381	6/23 (26%)
		leucine-rich repeat	481..500	CDD:275381	8/18 (44%)
		leucine-rich repeat	506..529	CDD:275381	8/22 (36%)
skp2	XP_005161246.1	F-box-like	105..150	CDD:289689	19/44 (43%)
		leucine-rich repeat	168..190	CDD:275381	7/24 (29%)
		AMN1	190..341	CDD:187754	50/150 (33%)
		leucine-rich repeat	191..215	CDD:275381	9/23 (39%)
		leucine-rich repeat	216..239	CDD:275381	9/22 (41%)
		leucine-rich repeat	240..265	CDD:275381	6/24 (25%)
		leucine-rich repeat	266..291	CDD:275381	7/24 (29%)
		leucine-rich repeat	292..318	CDD:275381	10/25 (40%)
		leucine-rich repeat	319..343	CDD:275381	6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587983
Domainoid	1	1.000	158	1.000	Domainoid score	I4096
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55942
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3823
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005610
OrthoInspector	1	1.000	-	-		oto39261
orthoMCL	1	0.900	-	-		OOG6_109192
Panther	1	1.100	-	-	LDO	PTHR16134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5156
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.920