DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl3

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001016128.1	Gene:	fbxl3 / 548882	XenbaseID:	XB-GENE-1014531	Length:	433	Species:	Xenopus tropicalis

Alignment Length:	322	Identity:	68/322 - (21%)
Similarity:	118/322 - (36%)	Gaps:	75/322 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLG----- 285
            |.||...:.|     .|..:|:|.||::||.......:.|||.:|.......||...:..
Frog    33 PEMSKSHDWG-----NLLPDIILQIFQYLPLLDRAHASQVCRNWNHVFHMPDLWRCFEFELNQPA 92

  Fly   286 ---LRTIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSS----- 342
               |....|..::||::|                       ....|||:...:.|...|:
Frog    93 TSYLNATHPDLIKQIIKR-----------------------HSNHLQYVSFKVDSSKESAEAACD 134

  Fly   343 LLTLLSHCRQLKKISLENIELDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLN 407
            :|:.|.:| .||.:.|  |........::.|:..:.|:.:...:.             .|||||.
Frog   135 ILSQLVNC-SLKTLGL--ISTARPSFMDLPKSHFISALTVVFVNS-------------KSLSSLK 183

  Fly   408 ISWTDLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVI 472
            |..|.:...::..||.:.|..|..|.::.|..| ..:.:..:..:|..|.||.| :...|:..::
Frog   184 IDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHV-SPAGILCVADQCHGLRELAL-NYYLLSDELL 246

  Fly   473 TAIM--KFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMGI 532
            .|:.  |...||:|.:.           .:...|..|.   |..:..::.:.|.|..||:.:
Frog   247 IALSSEKHVRLEHLRID-----------VVSENPGQTQ---FHTIQKSSWDALIKHSPKVNL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	13/44 (30%)
		leucine-rich repeat	302..327	CDD:275381	0/24 (0%)
		AMN1	309..480	CDD:187754	36/177 (20%)
		leucine-rich repeat	328..352	CDD:275381	8/28 (29%)
		leucine-rich repeat	353..376	CDD:275381	5/22 (23%)
		leucine-rich repeat	377..402	CDD:275381	1/24 (4%)
		leucine-rich repeat	403..428	CDD:275381	9/24 (38%)
		leucine-rich repeat	429..455	CDD:275381	5/25 (20%)
		leucine-rich repeat	456..480	CDD:275381	7/25 (28%)
		leucine-rich repeat	481..500	CDD:275381	3/18 (17%)
		leucine-rich repeat	506..529	CDD:275381	4/22 (18%)
fbxl3	NP_001016128.1	F-box-like	41..82	CDD:403981	13/45 (29%)
		leucine-rich repeat	179..204	CDD:275381	9/24 (38%)
		leucine-rich repeat	205..230	CDD:275381	5/25 (20%)
		leucine-rich repeat	231..256	CDD:275381	7/25 (28%)
		leucine-rich repeat	257..293	CDD:275381	10/49 (20%)
		leucine-rich repeat	294..338	CDD:275381	0/1 (0%)
		leucine-rich repeat	339..365	CDD:275381
		leucine-rich repeat	366..391	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010