DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl17

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_056609.1 Gene:Fbxl17 / 50758 MGIID:1354704 Length:701 Species:Mus musculus


Alignment Length:613 Identity:132/613 - (21%)
Similarity:215/613 - (35%) Gaps:166/613 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 LDSEESSSSA----LSAIALAVSATSDDNSNETTPCA---SVSRMAHQLQHTQRLSLGSTGDITL 123
            |.:|:.:::|    ||:.|.|.:|.|...|     |.   .::..|...|..:.|.|...|.:..
Mouse   109 LAAEDCAAAARRFLLSSAAAAAAAASSPAS-----CCKELGLAAAAAWEQQGRSLFLAGVGPVRF 168

  Fly   124 DSPAVEDSLSMS-------RQSAEKLQILAQAK-------------RSSLGSEGSGNSN------ 162
            ..|.....|..:       .:.|..|:::.:.|             |...|..|.|...      
Mouse   169 LGPLAAVQLFRAPPAPPPQAEPATALEMVCKRKGAGVPACTPCKQPRCGCGGCGGGGGGGGGPAG 233

  Fly   163 -----------------------------SPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRLAQ 198
                                         ||:......:||.....:..|||     ||:::   
Mouse   234 GGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIVAAAGDTVRAGGTA-----PSSAQ--- 290

  Fly   199 VRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLP-KKTLLRM 262
                ::|.:.:...:....:.....|.|...      |....:|...|||.||..|. .:..|..
Mouse   291 ----QQPESGDADCQEPPENPCDCHREPPPE------IPDINQLPPSILLKIFSNLSLNERCLSA 345

  Fly   263 ATVCRRFNRCSRDETLWTRLDLGLR-TIRPGALEQIVRRGVLVIRLAQTSIQE------------ 314
            :.||:.:.....|...|.:|||..| .:....||:|..|...:|.:..:..:.            
Mouse   346 SLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSLSDSGVCVLAFK 410

  Fly   315 -PAFAPYTEVFRTRLQYLDLSMASI------------------TRSSLLTLLSHCRQLKKISL-E 359
             |....|| .:|.: |..|.|:.::                  |...|..|.|.||:||.|.. :
Mouse   411 CPGLLRYT-AYRCK-QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQ 473

  Fly   360 NIELDDDICAEIAKNEALEAVNLTMASG--LTSNSVRLMME-------------SLTS------- 402
            ..::.|:....|||: .|:...:.|...  :|..||:...|             |:||       
Mouse   474 CYKISDEGMIVIAKS-CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLT 537

  Fly   403 ----LSSLNISW-TDLSADAVTALVTHISPNLIRLNIAGCRR-VLFDSHVATLQKRCPQLLELDL 461
                ||||::.. |:|..:.|..:|.... ||..||:  |.. ::.|..|..:.|....|.||.|
Mouse   538 KLRNLSSLDLRHITELDNETVMEIVKRCK-NLSSLNL--CLNWIINDRCVEVIAKEGQNLKELYL 599

  Fly   462 SDCNSLTPTVITAIMKFKM-LEYLSVSRCYLIP---ATKFIELKSMPSLTYLDIFGMLSDTAMEV 522
            ..| .:|...:.||.::.: :|.:.|..|..|.   ||  :..:|..||.||.:  |..|...|:
Mouse   600 VSC-KITDYALIAIGRYSVTIETVDVGWCKEITDQGAT--LIAQSSKSLRYLGL--MRCDKVNEL 659

  Fly   523 LEKQLPKMGINKFIHSSVSRPTVGTRRT 550
            ..:||    :.::.|.:.|......:||
Mouse   660 TVEQL----VQQYPHITFSTVLQDCKRT 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 13/45 (29%)
leucine-rich repeat 302..327 CDD:275381 5/37 (14%)
AMN1 309..480 CDD:187754 53/230 (23%)
leucine-rich repeat 328..352 CDD:275381 8/41 (20%)
leucine-rich repeat 353..376 CDD:275381 7/23 (30%)
leucine-rich repeat 377..402 CDD:275381 7/39 (18%)
leucine-rich repeat 403..428 CDD:275381 8/25 (32%)
leucine-rich repeat 429..455 CDD:275381 7/26 (27%)
leucine-rich repeat 456..480 CDD:275381 8/23 (35%)
leucine-rich repeat 481..500 CDD:275381 6/21 (29%)
leucine-rich repeat 506..529 CDD:275381 8/22 (36%)
Fbxl17NP_056609.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..93
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..250 0/22 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 279..321 9/59 (15%)
F-box-like 321..368 CDD:289689 14/46 (30%)
leucine-rich repeat 362..387 CDD:275381 9/24 (38%)
leucine-rich repeat 388..413 CDD:275381 1/24 (4%)
AMN1 411..573 CDD:187754 40/165 (24%)
leucine-rich repeat 414..439 CDD:275381 6/26 (23%)
leucine-rich repeat 440..465 CDD:275381 5/24 (21%)
leucine-rich repeat 466..491 CDD:275381 7/25 (28%)
leucine-rich repeat 492..517 CDD:275381 5/24 (21%)
leucine-rich repeat 545..567 CDD:275381 5/22 (23%)
leucine-rich repeat 568..593 CDD:275381 7/26 (27%)
leucine-rich repeat 594..618 CDD:275381 8/24 (33%)
leucine-rich repeat 619..644 CDD:275381 7/26 (27%)
leucine-rich repeat 645..670 CDD:275381 8/30 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167843135
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR16134
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.940

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