Protein Alignment Skp2 and Fbxl17

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_056609.1
• Gene: Fbxl17 / 50758
• MGIID: 1354704
• Length: 701
• Species: Mus musculus
• Alignment Length: 613
• Identity: 132/613 - (21%)
• Similarity: 215/613 - (35%)
• Gaps: 166/613 - (27%)

  Fly    66 LDSEESSSSA----LSAIALAVSATSDDNSNETTPCA---SVSRMAHQLQHTQRLSLGSTGDITL 123
            |.:|:.:::|    ||:.|.|.:|.|...|     |.   .::..|...|..:.|.|...|.:..
Mouse   109 LAAEDCAAAARRFLLSSAAAAAAAASSPAS-----CCKELGLAAAAAWEQQGRSLFLAGVGPVRF 168

  Fly   124 DSPAVEDSLSMS-------RQSAEKLQILAQAK-------------RSSLGSEGSGNSN------ 162
            ..|.....|..:       .:.|..|:::.:.|             |...|..|.|...
Mouse   169 LGPLAAVQLFRAPPAPPPQAEPATALEMVCKRKGAGVPACTPCKQPRCGCGGCGGGGGGGGGPAG 233

  Fly   163 -----------------------------SPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRLAQ 198
                                         ||:......:||.....:..|||     ||:::
Mouse   234 GGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIVAAAGDTVRAGGTA-----PSSAQ--- 290

  Fly   199 VRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLP-KKTLLRM 262
                ::|.:.:...:....:.....|.|...      |....:|...|||.||..|. .:..|..
Mouse   291 ----QQPESGDADCQEPPENPCDCHREPPPE------IPDINQLPPSILLKIFSNLSLNERCLSA 345

  Fly   263 ATVCRRFNRCSRDETLWTRLDLGLR-TIRPGALEQIVRRGVLVIRLAQTSIQE------------ 314
            :.||:.:.....|...|.:|||..| .:....||:|..|...:|.:..:..:.
Mouse   346 SLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSLSDSGVCVLAFK 410

  Fly   315 -PAFAPYTEVFRTRLQYLDLSMASI------------------TRSSLLTLLSHCRQLKKISL-E 359
             |....|| .:|.: |..|.|:.::                  |...|..|.|.||:||.|.. :
Mouse   411 CPGLLRYT-AYRCK-QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQ 473

  Fly   360 NIELDDDICAEIAKNEALEAVNLTMASG--LTSNSVRLMME-------------SLTS------- 402
            ..::.|:....|||: .|:...:.|...  :|..||:...|             |:||
Mouse   474 CYKISDEGMIVIAKS-CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLT 537

  Fly   403 ----LSSLNISW-TDLSADAVTALVTHISPNLIRLNIAGCRR-VLFDSHVATLQKRCPQLLELDL 461
                ||||::.. |:|..:.|..:|.... ||..||:  |.. ::.|..|..:.|....|.||.|
Mouse   538 KLRNLSSLDLRHITELDNETVMEIVKRCK-NLSSLNL--CLNWIINDRCVEVIAKEGQNLKELYL 599

  Fly   462 SDCNSLTPTVITAIMKFKM-LEYLSVSRCYLIP---ATKFIELKSMPSLTYLDIFGMLSDTAMEV 522
            ..| .:|...:.||.::.: :|.:.|..|..|.   ||  :..:|..||.||.:  |..|...|:
Mouse   600 VSC-KITDYALIAIGRYSVTIETVDVGWCKEITDQGAT--LIAQSSKSLRYLGL--MRCDKVNEL 659

  Fly   523 LEKQLPKMGINKFIHSSVSRPTVGTRRT 550
            ..:||    :.::.|.:.|......:||
Mouse   660 TVEQL----VQQYPHITFSTVLQDCKRT 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	12/42 (29%)
		leucine-rich repeat	302..327	CDD:275381	5/37 (14%)
		AMN1	309..480	CDD:187754	53/230 (23%)
		leucine-rich repeat	328..352	CDD:275381	8/41 (20%)
		leucine-rich repeat	353..376	CDD:275381	7/23 (30%)
		leucine-rich repeat	377..402	CDD:275381	7/39 (18%)
		leucine-rich repeat	403..428	CDD:275381	8/25 (32%)
		leucine-rich repeat	429..455	CDD:275381	7/26 (27%)
		leucine-rich repeat	456..480	CDD:275381	8/23 (35%)
		leucine-rich repeat	481..500	CDD:275381	6/21 (29%)
		leucine-rich repeat	506..529	CDD:275381	8/22 (36%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..250		0/22 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..321		9/59 (15%)
		F-box_FBXO13	320..368	CDD:438864	14/47 (30%)
		leucine-rich repeat	362..387	CDD:275381	9/24 (38%)
		leucine-rich repeat	388..413	CDD:275381	1/24 (4%)
		AMN1	411..573	CDD:187754	40/165 (24%)
		leucine-rich repeat	414..439	CDD:275381	6/26 (23%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
		leucine-rich repeat	466..491	CDD:275381	7/25 (28%)
		leucine-rich repeat	492..517	CDD:275381	5/24 (21%)
		leucine-rich repeat	545..567	CDD:275381	5/22 (23%)
		leucine-rich repeat	568..593	CDD:275381	7/26 (27%)
		leucine-rich repeat	594..618	CDD:275381	8/24 (33%)
		leucine-rich repeat	619..644	CDD:275381	7/26 (27%)
		leucine-rich repeat	645..670	CDD:275381	8/30 (27%)