DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl22

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001013297.1	Gene:	fbxl22 / 503591	ZFINID:	ZDB-GENE-050227-1	Length:	227	Species:	Danio rerio

Alignment Length:	308	Identity:	62/308 - (20%)
Similarity:	105/308 - (34%)	Gaps:	102/308 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIR 306
            |..|.||.:|.:|.|.:...::..|.|..:...|..|||.|..
Zfish     6 LDQECLLHLFSYLDKDSRRSLSLTCVRLRQVFLDPQLWTLLHF---------------------- 48

  Fly   307 LAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIE------LDD 365
                      ::|           .:|...:....|.|..|:.|....::.:.|||      ...
Zfish    49 ----------WSP-----------CELRRDNFVVGSSLRYLAVCWHSSRVKVCNIEHWMKTTFQK 92

  Fly   366 DICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHI---SP 427
            |:|   :|:|:.                                        |:..:.|:   .|
Zfish    93 DLC---SKHESF----------------------------------------VSDFLEHVCNMCP 114

  Fly   428 NLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKF-KMLEYLSVSRCYL 491
            |||.|.::||..:: |::|..:.:.|.:|..|.|.:|..:|.:|:.|.::. ..|..:.|..|..
Zfish   115 NLISLTLSGCGHIM-DNNVIKVLQSCRRLRSLSLENCARITDSVLKAAVEHGHNLTEVRVDFCRN 178

  Fly   492 IPATKFIELKSMPS---LTYLDIFGMLSDTAMEVLEKQLPKMGINKFI 536
            :......|||:...   |:.|....|:.|...|  ||...|..:.||:
Zfish   179 VTQAGLQELKNKKPEVLLSALHSADMIPDCKPE--EKTHIKRALQKFL 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	14/41 (34%)
		leucine-rich repeat	302..327	CDD:275381	1/24 (4%)
		AMN1	309..480	CDD:187754	32/180 (18%)
		leucine-rich repeat	328..352	CDD:275381	5/23 (22%)
		leucine-rich repeat	353..376	CDD:275381	6/28 (21%)
		leucine-rich repeat	377..402	CDD:275381	0/24 (0%)
		leucine-rich repeat	403..428	CDD:275381	2/27 (7%)
		leucine-rich repeat	429..455	CDD:275381	8/25 (32%)
		leucine-rich repeat	456..480	CDD:275381	7/24 (29%)
		leucine-rich repeat	481..500	CDD:275381	3/18 (17%)
		leucine-rich repeat	506..529	CDD:275381	7/22 (32%)
fbxl22	NP_001013297.1	F-box-like	9..48	CDD:289689	13/38 (34%)
		AMN1	<103..>191	CDD:187754	24/88 (27%)
		leucine-rich repeat	116..141	CDD:275381	8/25 (32%)
		leucine-rich repeat	142..167	CDD:275381	7/24 (29%)
		leucine-rich repeat	168..187	CDD:275381	3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930